Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNG2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with Cardiovascular. Connected to 24 entities in the SciDEX knowledge graph.
| Gene Symbol | GNG2 |
| Full Name | G protein subunit gamma 2 |
| Chromosome | 14q21.3 |
| Protein Family | G protein gamma subunit family |
| Function | encodes a critical component of heterotrimeric G proteins that mediate cellular signaling throughout the nervous system. |
| Molecular Weight | 7.6 kDa |
| Amino Acids | 71 aa |
| Exons | 4 |
| Pathways | PI3K |
| UniProt ID | [P59768](https://www.uniprot.org/uniprot/P59768) |
| Ensembl ID | ENSG00000186472 |
| OMIM | 606314 |
| GeneCards | GNG2 |
| Human Protein Atlas | GNG2 |
| Associated Diseases | neurodegeneration |
| Interactions | GNAI2, NOD2, GNAS, GNAI3, AKT1, AKT |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNG2["<b>GNG2</b>"]
Cardiovascular{"Cardiovascular"}
GNG2 -->|"expressed in"| Cardiovascular
WDR81["WDR81"]
GNG2 -->|"expressed in"| WDR81
GNPTG["GNPTG"]
GNG2 -->|"expressed in"| GNPTG
GNAI2["GNAI2"]
GNG2 -->|"interacts with"| GNAI2
NOD2["NOD2"]
GNG2 -->|"interacts with"| NOD2
GNAS["GNAS"]
GNG2 -->|"interacts with"| GNAS
GNAI3["GNAI3"]
GNG2 -->|"interacts with"| GNAI3
Autophagy(["Autophagy"])
GNG2 -->|"interacts with"| Autophagy
Wnt(["Wnt"])
GNG2 -->|"expressed in"| Wnt
Akt(["Akt"])
GNG2 -->|"interacts with"| Akt
neurodegeneration["neurodegeneration"]
GNG2 -->|"implicated in"| neurodegeneration
AKT1["AKT1"]
AKT1 -->|"interacts with"| GNG2
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"interacts with"| GNG2
AKT["AKT"]
AKT -->|"interacts with"| GNG2
GNB1["GNB1"]
GNB1 -->|"interacts with"| GNG2
AMPD2["AMPD2"]
AMPD2 -->|"expressed in"| GNG2
ATG5["ATG5"]
ATG5 -->|"interacts with"| GNG2
MAVS["MAVS"]
MAVS -->|"interacts with"| GNG2
TBK1["TBK1"]
TBK1 -->|"interacts with"| GNG2
CLCN7["CLCN7"]
CLCN7 -->|"expressed in"| GNG2
RIPK2["RIPK2"]
RIPK2 -->|"interacts with"| GNG2
IFIH1["IFIH1"]
IFIH1 -->|"interacts with"| GNG2
GNAI1["GNAI1"]
GNAI1 -->|"interacts with"| GNG2
style GNG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiovascular | expressed_in | disease | 0.65 |
| WDR81 | expressed_in | gene | 0.60 |
| GNPTG | expressed_in | gene | 0.60 |
| GNAI2 | interacts_with | gene | 0.60 |
| NOD2 | interacts_with | gene | 0.60 |
| GNAS | interacts_with | gene | 0.60 |
| GNAI3 | interacts_with | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| Akt | interacts_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT1 | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| GNB1 | interacts_with | gene | 0.60 |
| AMPD2 | expressed_in | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| TBK1 | interacts_with | gene | 0.60 |
| CLCN7 | expressed_in | gene | 0.60 |
| RIPK2 | interacts_with | gene | 0.60 |
| IFIH1 | interacts_with | gene | 0.60 |
| GNAI1 | interacts_with | gene | 0.60 |
| ATG16L1 | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||