gene

GNG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections
0Hypotheses
0Analyses
10Outgoing
13Incoming

Summary

GNG2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with Cardiovascular. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGNG2
Full NameG protein subunit gamma 2
Chromosome14q21.3
Protein FamilyG protein gamma subunit family
Functionencodes a critical component of heterotrimeric G proteins that mediate cellular signaling throughout the nervous system.
Molecular Weight7.6 kDa
Amino Acids71 aa
Exons4
PathwaysPI3K
UniProt ID[P59768](https://www.uniprot.org/uniprot/P59768)
Ensembl IDENSG00000186472
OMIM606314
GeneCardsGNG2
Human Protein AtlasGNG2
Associated Diseasesneurodegeneration
InteractionsGNAI2, NOD2, GNAS, GNAI3, AKT1, AKT
KG Connections23 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

GNG2 Gene

gene · 2140 words

GNB4 Protein — G Protein Subunit Beta 4

protein · 2562 words

GNG3 Protein

protein · 1874 words

GNB5 (G Protein Subunit Beta 5)

protein · 1749 words

AMPD2 — Adenosine Monophosphate Deaminase 2

gene · 1710 words

GNB4 Gene — G Protein Subunit Beta 4

gene · 1675 words

Pathway Diagram

graph TD
    GNG2["<b>GNG2</b>"]
    Cardiovascular{"Cardiovascular"}
    GNG2 -->|"expressed in"| Cardiovascular
    WDR81["WDR81"]
    GNG2 -->|"expressed in"| WDR81
    GNPTG["GNPTG"]
    GNG2 -->|"expressed in"| GNPTG
    GNAI2["GNAI2"]
    GNG2 -->|"interacts with"| GNAI2
    NOD2["NOD2"]
    GNG2 -->|"interacts with"| NOD2
    GNAS["GNAS"]
    GNG2 -->|"interacts with"| GNAS
    GNAI3["GNAI3"]
    GNG2 -->|"interacts with"| GNAI3
    Autophagy(["Autophagy"])
    GNG2 -->|"interacts with"| Autophagy
    Wnt(["Wnt"])
    GNG2 -->|"expressed in"| Wnt
    Akt(["Akt"])
    GNG2 -->|"interacts with"| Akt
    neurodegeneration["neurodegeneration"]
    GNG2 -->|"implicated in"| neurodegeneration
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| GNG2
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| GNG2
    AKT["AKT"]
    AKT -->|"interacts with"| GNG2
    GNB1["GNB1"]
    GNB1 -->|"interacts with"| GNG2
    AMPD2["AMPD2"]
    AMPD2 -->|"expressed in"| GNG2
    ATG5["ATG5"]
    ATG5 -->|"interacts with"| GNG2
    MAVS["MAVS"]
    MAVS -->|"interacts with"| GNG2
    TBK1["TBK1"]
    TBK1 -->|"interacts with"| GNG2
    CLCN7["CLCN7"]
    CLCN7 -->|"expressed in"| GNG2
    RIPK2["RIPK2"]
    RIPK2 -->|"interacts with"| GNG2
    IFIH1["IFIH1"]
    IFIH1 -->|"interacts with"| GNG2
    GNAI1["GNAI1"]
    GNAI1 -->|"interacts with"| GNG2
    style GNG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

TargetRelationTypeStr
Cardiovascularexpressed_indisease0.65
WDR81expressed_ingene0.60
GNPTGexpressed_ingene0.60
GNAI2interacts_withgene0.60
NOD2interacts_withgene0.60

Incoming (13)

SourceRelationTypeStr
AKT1interacts_withgene0.60
AKTinteracts_withgene0.60
GNB1interacts_withgene0.60
AMPD2expressed_ingene0.60
ATG5interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found