gene

GNAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections
0Hypotheses
0Analyses
11Outgoing
20Incoming

Summary

GNAS is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, expressed in. Associated with Als, Cancer, Cardiovascular. Connected to 32 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGNAS
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionendocrine tissues, heart, kidney
PathwaysMAPK pathway
GeneCardsGNAS
Human Protein AtlasGNAS
Adenylyl cyclase activationStimulates cAMP production
GTP binding and hydrolysisClassic G protein cycle
Effector pathwaysActivates adenylyl cyclase isoforms I-IX
Alternative splicingMultiple splice variants with distinct functions
Stimulatory signalingGs proteins promote cAMP formation
Isoform diversityGαs, Gαs-L, Gαolf, GαsXL
ImprintingGNAS is imprinted in a tissue-specific manner
Second messenger systemcAMP is the primary second messenger
BrainWidespread expression throughout the CNS
Associated Diseasesneurodegeneration
InteractionsGNAI3, MITOPHAGY, BNIP3L, AKT1, AKT, GNB1
KG Connections31 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

gnas Gene

gene · 692 words

gnas-protein

protein · 2567 words

WDR81 — WD Repeat Domain 81

gene · 2168 words

GNG2 Gene

gene · 2140 words

ADCY5 Gene

gene · 1894 words

G Proteins

mechanism · 1607 words

Pathway Diagram

graph TD
    GNAS["<b>GNAS</b>"]
    Tumor{"Tumor"}
    GNAS -->|"activates"| Tumor
    Als{"Als"}
    GNAS -->|"interacts with"| Als
    Cancer{"Cancer"}
    GNAS -->|"activates"| Cancer
    Cardiovascular{"Cardiovascular"}
    GNAS -->|"expressed in"| Cardiovascular
    Epigenetic(["Epigenetic"])
    GNAS -->|"activates"| Epigenetic
    MITOPHAGY["MITOPHAGY"]
    GNAS -->|"activates"| MITOPHAGY
    Mitophagy(["Mitophagy"])
    GNAS -->|"activates"| Mitophagy
    GNAI3["GNAI3"]
    GNAS -->|"interacts with"| GNAI3
    Autophagy(["Autophagy"])
    GNAS -->|"interacts with"| Autophagy
    Wnt(["Wnt"])
    GNAS -->|"expressed in"| Wnt
    Akt(["Akt"])
    GNAS -->|"interacts with"| Akt
    neurodegeneration["neurodegeneration"]
    GNAS -->|"implicated in"| neurodegeneration
    BNIP3L["BNIP3L"]
    BNIP3L -->|"activates"| GNAS
    CANCER["CANCER"]
    CANCER -->|"activates"| GNAS
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| GNAS
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| GNAS
    AKT["AKT"]
    AKT -->|"interacts with"| GNAS
    GNB1["GNB1"]
    GNB1 -->|"interacts with"| GNAS
    AMPD2["AMPD2"]
    AMPD2 -->|"expressed in"| GNAS
    ATG5["ATG5"]
    ATG5 -->|"interacts with"| GNAS
    MAVS["MAVS"]
    MAVS -->|"interacts with"| GNAS
    TBK1["TBK1"]
    TBK1 -->|"interacts with"| GNAS
    CLCN7["CLCN7"]
    CLCN7 -->|"expressed in"| GNAS
    RIPK2["RIPK2"]
    RIPK2 -->|"interacts with"| GNAS
    style GNAS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

TargetRelationTypeStr
Tumoractivatesdisease0.65
Alsinteracts_withdisease0.65
Canceractivatesdisease0.65
Cardiovascularexpressed_indisease0.65
GNAI3interacts_withgene0.60

Incoming (20)

SourceRelationTypeStr
BNIP3Lactivatesgene0.60
AKT1interacts_withgene0.60
AKTinteracts_withgene0.60
GNB1interacts_withgene0.60
AMPD2expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found