Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNAS is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, expressed in. Associated with Als, Cancer, Cardiovascular. Connected to 32 entities in the SciDEX knowledge graph.
| Gene Symbol | GNAS |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | endocrine tissues, heart, kidney |
| Pathways | MAPK pathway |
| GeneCards | GNAS |
| Human Protein Atlas | GNAS |
| Adenylyl cyclase activation | Stimulates cAMP production |
| GTP binding and hydrolysis | Classic G protein cycle |
| Effector pathways | Activates adenylyl cyclase isoforms I-IX |
| Alternative splicing | Multiple splice variants with distinct functions |
| Stimulatory signaling | Gs proteins promote cAMP formation |
| Isoform diversity | Gαs, Gαs-L, Gαolf, GαsXL |
| Imprinting | GNAS is imprinted in a tissue-specific manner |
| Second messenger system | cAMP is the primary second messenger |
| Brain | Widespread expression throughout the CNS |
| Associated Diseases | neurodegeneration |
| Interactions | GNAI3, MITOPHAGY, BNIP3L, AKT1, AKT, GNB1 |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNAS["<b>GNAS</b>"]
Tumor{"Tumor"}
GNAS -->|"activates"| Tumor
Als{"Als"}
GNAS -->|"interacts with"| Als
Cancer{"Cancer"}
GNAS -->|"activates"| Cancer
Cardiovascular{"Cardiovascular"}
GNAS -->|"expressed in"| Cardiovascular
Epigenetic(["Epigenetic"])
GNAS -->|"activates"| Epigenetic
MITOPHAGY["MITOPHAGY"]
GNAS -->|"activates"| MITOPHAGY
Mitophagy(["Mitophagy"])
GNAS -->|"activates"| Mitophagy
GNAI3["GNAI3"]
GNAS -->|"interacts with"| GNAI3
Autophagy(["Autophagy"])
GNAS -->|"interacts with"| Autophagy
Wnt(["Wnt"])
GNAS -->|"expressed in"| Wnt
Akt(["Akt"])
GNAS -->|"interacts with"| Akt
neurodegeneration["neurodegeneration"]
GNAS -->|"implicated in"| neurodegeneration
BNIP3L["BNIP3L"]
BNIP3L -->|"activates"| GNAS
CANCER["CANCER"]
CANCER -->|"activates"| GNAS
AKT1["AKT1"]
AKT1 -->|"interacts with"| GNAS
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"interacts with"| GNAS
AKT["AKT"]
AKT -->|"interacts with"| GNAS
GNB1["GNB1"]
GNB1 -->|"interacts with"| GNAS
AMPD2["AMPD2"]
AMPD2 -->|"expressed in"| GNAS
ATG5["ATG5"]
ATG5 -->|"interacts with"| GNAS
MAVS["MAVS"]
MAVS -->|"interacts with"| GNAS
TBK1["TBK1"]
TBK1 -->|"interacts with"| GNAS
CLCN7["CLCN7"]
CLCN7 -->|"expressed in"| GNAS
RIPK2["RIPK2"]
RIPK2 -->|"interacts with"| GNAS
style GNAS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | activates | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Cardiovascular | expressed_in | disease | 0.65 |
| GNAI3 | interacts_with | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
| Mitophagy | activates | pathway | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| Akt | interacts_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BNIP3L | activates | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| GNB1 | interacts_with | gene | 0.60 |
| AMPD2 | expressed_in | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| TBK1 | interacts_with | gene | 0.60 |
| CLCN7 | expressed_in | gene | 0.60 |
| RIPK2 | interacts_with | gene | 0.60 |
| IFIH1 | interacts_with | gene | 0.60 |
| GNAI1 | interacts_with | gene | 0.60 |
| ATG16L1 | interacts_with | gene | 0.60 |
| GNG2 | interacts_with | gene | 0.60 |
| WDR81 | expressed_in | gene | 0.60 |
| GNPTG | expressed_in | gene | 0.60 |
| GNAI2 | interacts_with | gene | 0.60 |
| NOD2 | interacts_with | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||