gene

GNB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections
0Hypotheses
0Analyses
20Outgoing
3Incoming
0Experiments

Summary

GNB1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with Cardiovascular. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGNB1
Full NameG Protein Subunit Beta 1
AliasesPage for GNB1 Gene
Chromosome1p36.33
FunctionGNB1/Gβ1 is part of the G protein trimer (Gαβγ)
Primary Expressionmost tissues with highest expression in:
UniProt IDP62879
NCBI Gene ID2782
Ensembl IDENSG00000120788
OMIM139311
GeneCardsGNB1
Human Protein AtlasGNB1
Associated Diseasesneurodegeneration
InteractionsATG5, MAVS, TBK1, RIPK2, IFIH1, GNAI1
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GNB1 — AlphaFold P62879 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

GNB1 Gene - G Protein Subunit Beta 1

gene · 691 words

GNB4 Protein — G Protein Subunit Beta 4

protein · 2562 words

GNG2 Gene

gene · 2140 words

GNAT1 (G Protein Alpha Transducin 1)

protein · 1908 words

GNG3 Protein

protein · 1874 words

RGS12 Protein

protein · 1680 words

Pathway Diagram

graph TD
    GNB1["<b>GNB1</b>"]
    Cardiovascular{"Cardiovascular"}
    GNB1 -->|"expressed in"| Cardiovascular
    AMPD2["AMPD2"]
    GNB1 -->|"expressed in"| AMPD2
    ATG5["ATG5"]
    GNB1 -->|"interacts with"| ATG5
    MAVS["MAVS"]
    GNB1 -->|"interacts with"| MAVS
    TBK1["TBK1"]
    GNB1 -->|"interacts with"| TBK1
    CLCN7["CLCN7"]
    GNB1 -->|"expressed in"| CLCN7
    RIPK2["RIPK2"]
    GNB1 -->|"interacts with"| RIPK2
    IFIH1["IFIH1"]
    GNB1 -->|"interacts with"| IFIH1
    GNAI1["GNAI1"]
    GNB1 -->|"interacts with"| GNAI1
    ATG16L1["ATG16L1"]
    GNB1 -->|"interacts with"| ATG16L1
    GNG2["GNG2"]
    GNB1 -->|"interacts with"| GNG2
    WDR81["WDR81"]
    GNB1 -->|"expressed in"| WDR81
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| GNB1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| GNB1
    AKT["AKT"]
    AKT -->|"interacts with"| GNB1
    style GNB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

TargetRelationTypeStr
Cardiovascularexpressed_indisease0.65
AMPD2expressed_ingene0.60
ATG5interacts_withgene0.60
MAVSinteracts_withgene0.60
TBK1interacts_withgene0.60

Incoming (3)

SourceRelationTypeStr
AKT1interacts_withgene0.60
AKTinteracts_withgene0.60
AUTOPHAGYinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found