Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNB1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with Cardiovascular. Connected to 24 entities in the SciDEX knowledge graph.
| Gene Symbol | GNB1 |
| Full Name | G Protein Subunit Beta 1 |
| Aliases | Page for GNB1 Gene |
| Chromosome | 1p36.33 |
| Function | GNB1/Gβ1 is part of the G protein trimer (Gαβγ) |
| Primary Expression | most tissues with highest expression in: |
| UniProt ID | P62879 |
| NCBI Gene ID | 2782 |
| Ensembl ID | ENSG00000120788 |
| OMIM | 139311 |
| GeneCards | GNB1 |
| Human Protein Atlas | GNB1 |
| Associated Diseases | neurodegeneration |
| Interactions | ATG5, MAVS, TBK1, RIPK2, IFIH1, GNAI1 |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GNB1["<b>GNB1</b>"]
Cardiovascular{"Cardiovascular"}
GNB1 -->|"expressed in"| Cardiovascular
AMPD2["AMPD2"]
GNB1 -->|"expressed in"| AMPD2
ATG5["ATG5"]
GNB1 -->|"interacts with"| ATG5
MAVS["MAVS"]
GNB1 -->|"interacts with"| MAVS
TBK1["TBK1"]
GNB1 -->|"interacts with"| TBK1
CLCN7["CLCN7"]
GNB1 -->|"expressed in"| CLCN7
RIPK2["RIPK2"]
GNB1 -->|"interacts with"| RIPK2
IFIH1["IFIH1"]
GNB1 -->|"interacts with"| IFIH1
GNAI1["GNAI1"]
GNB1 -->|"interacts with"| GNAI1
ATG16L1["ATG16L1"]
GNB1 -->|"interacts with"| ATG16L1
GNG2["GNG2"]
GNB1 -->|"interacts with"| GNG2
WDR81["WDR81"]
GNB1 -->|"expressed in"| WDR81
AKT1["AKT1"]
AKT1 -->|"interacts with"| GNB1
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"interacts with"| GNB1
AKT["AKT"]
AKT -->|"interacts with"| GNB1
style GNB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiovascular | expressed_in | disease | 0.65 |
| AMPD2 | expressed_in | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| TBK1 | interacts_with | gene | 0.60 |
| CLCN7 | expressed_in | gene | 0.60 |
| RIPK2 | interacts_with | gene | 0.60 |
| IFIH1 | interacts_with | gene | 0.60 |
| GNAI1 | interacts_with | gene | 0.60 |
| ATG16L1 | interacts_with | gene | 0.60 |
| GNG2 | interacts_with | gene | 0.60 |
| WDR81 | expressed_in | gene | 0.60 |
| GNPTG | expressed_in | gene | 0.60 |
| GNAI2 | interacts_with | gene | 0.60 |
| NOD2 | interacts_with | gene | 0.60 |
| GNAS | interacts_with | gene | 0.60 |
| GNAI3 | interacts_with | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| Akt | interacts_with | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||