concept

SLEEP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLEEP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

158Connections

15Hypotheses

2Analyses

48Outgoing

50Incoming

16Experiments

2Debates

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💡 Concept Info

Name	SLEEP
Key Genes/Proteins	ALZHEIMER DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

REM Sleep Behavior Disorder (RBD) - Diagnostic Marker for Synucleinopathies

diagnostic · 1866 words

→

Pathway Diagram

graph TD
    SLEEP["SLEEP"]
    SLEEP -->|"activates"| Glymphatic_Pathway["Glymphatic Pathway"]
    SLEEP -->|"modulates"| CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    SLEEP -->|"modulates"| Circadian_Rhythm["Circadian Rhythm"]
    SLEEP -->|"contributes to"| Healthy_Brain_Aging["Healthy Brain Aging"]
    SLEEP -->|"regulates"| HSPA1A["HSPA1A"]
    GABAergic_Interneurons["GABAergic Interneurons"] -->|"regulates"| SLEEP
    Circadian_Clocks["Circadian Clocks"] -->|"regulates"| SLEEP
    Caffeine["Caffeine"] -->|"modulates"| SLEEP
    Serotonin["Serotonin"] -->|"regulates"| SLEEP
    HSPA1A -->|"regulates"| SLEEP
    ADENOSINE_RECEPTORS["ADENOSINE RECEPTORS"] -->|"regulates"| SLEEP
    n_5_HT["5-HT"] -->|"modulates"| SLEEP
    MTNR1B["MTNR1B"] -->|"regulates"| SLEEP

Outgoing (48)

Target	Relation	Type	Str
interstitial space	associated_with	process	0.95
β-amyloid	associated_with	protein	0.95
Metabolite Clearance	promotes	process	0.95
glymphatic_clearance	activates	mechanism	0.95
Waste Product Removal	promotes	process	0.92
Glymphatic Pathway	activates	pathway	0.92
Metabolic Homeostasis	involved_in	process	0.90
glymphatic system activity	activates	process	0.90
CIRCADIAN RHYTHM	modulates	entity	0.90
cerebrospinal fluid	modulates	compound	0.90
central nervous system	associated_with	brain_region	0.90
neurotoxic waste products	associated_with	compound	0.90
Glymphatic Transport	regulates	process	0.90
Circadian Rhythm	modulates	process	0.85
Brain_Homeostasis	associated_with	process	0.85
Interstitial Space	modulates	phenotype	0.85
APOE	associated_with	protein	0.85
cellular repair mechanisms	mediates	process	0.85
Brain Homeostasis	associated_with	process	0.85
Healthy Brain Aging	contributes_to	phenotype	0.80
Neurodegeneration_Processes	modulates	process	0.80
Neurodegeneration	associated_with	disease	0.80
Healthy_Brain_Aging	promotes	phenotype	0.80
Cognitive Function	contributes_to	phenotype	0.80
Alzheimer Disease	biomarker_for	disease	0.75
HSPA1A	regulates	protein	0.75
Cancer	associated_with	disease	0.75
Cognition	correlates_with	phenotype	0.75
Cognitive Function	regulates	phenotype	0.70
glymphatic clearance	activates	process	0.70
GLYMPHATIC CLEARANCE	regulates	phenotype	0.70
TAU	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
MICROGLIA	causes	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
TBI	co_discussed	entity	0.50
SOD1	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
TLR4	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
UNFOLDED PROTEIN RESPONSE	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50

Incoming (110)

Source	Relation	Type	Str
34902819	influences	paper	0.90
Circadian Clocks	regulates	process	0.90
GABAergic Interneurons	regulates	cell_type	0.90
Caffeine	modulates	compound	0.90
33268891	promote	paper	0.90
33268891	needed for	paper	0.90
Serotonin	regulates	compound	0.90
41579208	regulates	paper	0.90
28514446	induces	paper	0.90
HSPA1A	regulates	gene	0.85
Hsp70	associated_with	protein	0.85
ADENOSINE RECEPTORS	regulates	receptor	0.85
Brain Function	associated_with	process	0.80
5-HT	modulates	compound	0.75
melatonin receptor 2	regulates	gene	0.70
Alzheimer's Disease	modulates	disease	0.70
HSPA1A	associated_with	gene	0.60
25947369	enables elimination of	paper	0.60
MTNR1B	regulates	gene	0.60
34902819	associated with	paper	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
40830882	reduces	paper	0.60
40830882	increases	paper	0.60
HYPOTHALAMUS	co_discussed	entity	0.50
ER STRESS	co_discussed	entity	0.50
BLOOD-BRAIN BARRIER	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
MITOCHONDRIAL DYSFUNCTION	co_discussed	entity	0.50
LIPID METABOLISM	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
GBA	co_discussed	entity	0.50
LRRK2	co_discussed	entity	0.50
MONOCYTE	co_discussed	entity	0.50
MONOCYTES	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
AMYGDALA	co_discussed	entity	0.50
CHOLINERGIC	co_discussed	entity	0.50
P2RX7	co_discussed	entity	0.50
IL1B	co_discussed	entity	0.50
OCLN	co_discussed	entity	0.50
PARP1	co_discussed	entity	0.50
PYROPTOSIS	co_discussed	entity	0.50
CERAMIDE	co_discussed	entity	0.50
CYTOKINE	co_discussed	entity	0.50
INFLAMMASOME	co_discussed	entity	0.50
ALPHA-SYNUCLEIN	co_discussed	entity	0.50
BBB	co_discussed	entity	0.50
SEROTONERGIC	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sleep-Dependent Glymphatic Clearance Expands the Therapeutic	0.780	neurodegeneration	What is the therapeutic window between t
Night-phase orexin receptor antagonism rescues AD by restori	0.758	neurodegeneration	Orexin-A manipulation in AD cognition an
Sleep Spindle-Synaptic Plasticity Enhancement	0.721	neurodegeneration	Sleep disruption as cause and consequenc
Biorhythmic Interference via Controlled Sleep Oscillations	0.661	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Treat Glymphatic Failure by Coupling AQP4-Targeted Therapy t	0.630	neurodegeneration	How can AQP4 be effectively targeted the

A lower trazodone dose of 50-100 mg nightly may be sufficien	0.580	neurodegeneration	-
Restorative Sleep Induction as the Threshold Mechanism: Dose	0.545	-	What is the minimum effective dose of tr
Sleep-Stage TFUS to Restore SWR-Gamma Coupling and Memory Co	0.525	alzheimers	Closed-loop transcranial focused ultraso
Complement Regulator CD55/CD46 Expression Modulates Microgli	0.380	synaptic-biology	What determines the selectivity of compl
Biofluid-Guided Predictive Sleep Intervention	0.000	-	Sleep disruption as cause and consequenc
Sleep-Dependent Synaptic Plasticity Restoration	0.000	-	Sleep disruption as cause and consequenc
Sleep Architecture Optimization via Glymphatic Pacing	0.000	-	Perivascular spaces and glymphatic clear
Glymphatic Enhancement Through Controlled Sleep Depth Modula	0.000	-	Sleep disruption as cause and consequenc
Metabotropic Glutamate Receptor-Based Sleep Stabilization Th	0.000	-	Sleep disruption as cause and consequenc
Trauma-Induced Sleep Disruption as Therapeutic Window	0.000	-	Sleep disruption as cause and consequenc

Mentioning Analyses (2)

Scientific analyses that reference this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.735

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (16)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Phenobarbital treatment efficacy study	clinical	intractable epilepsy	0.900	0.00	human patient and Gabra1+/-/Ga	proposed	N/A
Gabra1+/-/Gabrg2+/- mouse model characterization	validation	epilepsy with optic atrophy	0.900	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
Optic nerve myelination analysis	exploratory	optic atrophy	0.880	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
GABAA receptor subunit expression analysis	exploratory	epilepsy	0.850	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Neural Oscillation Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Circadian Dysfunction as Driver of Neurodegeneration	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep Disruption and Alzheimer's Disease — mechanism and intervention	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
A brain-to-gut signal controls intestinal fat absorption. [PMID:39261733]	Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB,	Nature	2024	1
Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human [PMID:37703949]	Zhang Q, Forster-Gibson C, Bercovici E,	Exp Neurol	2023	1
Pharmacogenetics of anxiety and depression in Alzheimer's disease. [PMID:36628952]	Cacabelos R, Carril JC, Corzo L, Pego R,	Pharmacogenomics	2023	1
Genetic factors in precocious puberty. [PMID:34665958]	Shim YS, Lee HS, Hwang JS	Clin Exp Pediatr	2022	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Effects of caffeine on sleep and cognition. [PMID:21531247]	Snel J, Lorist MM	Prog Brain Res	2011	1
Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808]	Kunttas-Tatli E, Bose A, Kahali B, Bisho	Genesis	2009	1
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970]	Lu W, Kawatani K, Ren Y	Alzheimers Res Ther	2026	0
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026	0
Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108]	Pruitt A, Yang L, Lee S, Balafkan N, Sea	bioRxiv : the preprint server	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Prenatal alcohol exposure dysregulates the expression of clock genes and alters [PMID:41086861]	Reina-Campos M, Gallego-Landin I, Medran	Open biology	2025	0
Sleep-improving effect and the potential mechanism of Morus alba L. on mice. [PMID:39255910]	Kong X, Zhou X, Li R, Kang Q, Hao L, Zhu	Fitoterapia	2024	0
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098]	["Oristrell J", "Oliva J", "Casado E", "	Journal of endocrinological in	2022	0
Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388]	Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y,	Seizure	2022	0
To beat Omicron, Delta and bird flu, Europe must pull together [PMID:34893768]	Desvars-Larrive Amélie	Nature	2021	0
Facilitating successful online meetings in healthcare. [PMID:33789331]	Dennis Sherrod; Cecil Holland	Nursing management	2021	0
Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341]	Rátkai A, Tárnok K, Aouad HE, Micska B,	Scientific reports	2021	0
Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196]	["Zhu X", "Zhou B", "Pattni R", "Gleason	Nature neuroscience	2021	0

Debates (2)

Multi-agent debates referencing this entity

What is the optimal dosage and timing of melatonin administration for AD prevent

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

What are the mechanisms underlying sleep disruption as cause and consequence of

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning SLEEP in their description or question text

Restorative Sleep Induction as the Threshold Mechanism: Dose-Dependent REM Enhan

Score: 0.545 · unknown disease · 2026-04-26

At doses of 50-100 mg, trazodone increases slow-wave sleep continuity and REM duration, indirectly enhancing glymphatic

Sleep-Stage TFUS to Restore SWR-Gamma Coupling and Memory Consolidation

Score: 0.525 · alzheimers · 2026-04-28

H4 represents the strongest systems-neuroscience endpoint from the debate, focusing on restoring hippocampal sleep physi

Complement Regulator CD55/CD46 Expression Modulates Microglial Engulfment During

Score: 0.380 · synaptic-biology · 2026-04-27

The circadian-regulated expression of complement regulators CD55 and CD46 on synaptic membranes establishes a temporal g