Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLEEP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SLEEP |
| Summary | Page for Cerêve |
| Key Genes/Proteins | melatonin receptor 2 |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
SLEEP["SLEEP"]
SLEEP -->|"activates"| Glymphatic_Pathway["Glymphatic Pathway"]
SLEEP -->|"modulates"| CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
SLEEP -->|"modulates"| Circadian_Rhythm["Circadian Rhythm"]
SLEEP -->|"contributes to"| Healthy_Brain_Aging["Healthy Brain Aging"]
SLEEP -->|"regulates"| HSPA1A["HSPA1A"]
GABAergic_Interneurons["GABAergic Interneurons"] -->|"regulates"| SLEEP
Circadian_Clocks["Circadian Clocks"] -->|"regulates"| SLEEP
Caffeine["Caffeine"] -->|"modulates"| SLEEP
Serotonin["Serotonin"] -->|"regulates"| SLEEP
HSPA1A -->|"regulates"| SLEEP
ADENOSINE_RECEPTORS["ADENOSINE RECEPTORS"] -->|"regulates"| SLEEP
n_5_HT["5-HT"] -->|"modulates"| SLEEP
MTNR1B["MTNR1B"] -->|"regulates"| SLEEP| Target | Relation | Type | Str |
|---|---|---|---|
| CIRCADIAN RHYTHM | modulates | entity | 0.90 |
| T CELL | co_discussed | entity | 0.50 |
| STING | co_discussed | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| melatonin receptor 2 | regulates | gene | 0.70 |
| NEURODEGENERATION | co_discussed | entity | 0.50 |
| HSPA1A | co_discussed | entity | 0.50 |
| APOPTOSIS | co_discussed | entity | 0.50 |
| ALZHEIMER | co_discussed | entity | 0.50 |
| ALZHEIMER'S | co_discussed | entity | 0.50 |
| CIRCADIAN | co_discussed | entity | 0.50 |
| GLYMPHATIC | co_discussed | entity | 0.50 |
| AQP4 | co_discussed | entity | 0.50 |
| ASTROCYTE | co_discussed | entity | 0.50 |
| NEURON | co_discussed | entity | 0.50 |
| NEURONS | co_discussed | entity | 0.50 |
| PARKINSON | co_discussed | entity | 0.50 |
| PARKINSON'S | co_discussed | entity | 0.50 |
| SCHIZOPHRENIA | co_discussed | entity | 0.50 |
| DEPRESSION | co_discussed | entity | 0.50 |
| EPILEPSY | co_discussed | entity | 0.50 |
| DOPAMINERGIC | co_discussed | entity | 0.50 |
| GABA | co_discussed | entity | 0.50 |
| GABAergic | co_discussed | entity | 0.50 |
| NEUROINFLAMMATION | co_discussed | entity | 0.50 |
| OXIDATIVE STRESS | co_discussed | entity | 0.50 |
| MICROGLIA | co_discussed | entity | 0.50 |
| INTERNEURONS | co_discussed | entity | 0.50 |
| ASTROCYTES | co_discussed | entity | 0.50 |
| APP | co_discussed | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Sleep Spindle-Synaptic Plasticity Enhancement | 0.491 | neurodegeneration | Sleep disruption as cause and consequenc |
| Biorhythmic Interference via Controlled Sleep Oscillations | 0.412 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
chronobiology | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| A brain-to-gut signal controls intestinal fat absorption. [PMID:39261733] | Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, | Nature | 2024 | 1 |
| Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human [PMID:37703949] | Zhang Q, Forster-Gibson C, Bercovici E, | Exp Neurol | 2023 | 1 |
| Pharmacogenetics of anxiety and depression in Alzheimer's disease. [PMID:36628952] | Cacabelos R, Carril JC, Corzo L, Pego R, | Pharmacogenomics | 2023 | 1 |
| Genetic factors in precocious puberty. [PMID:34665958] | Shim YS, Lee HS, Hwang JS | Clin Exp Pediatr | 2022 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Effects of caffeine on sleep and cognition. [PMID:21531247] | Snel J, Lorist MM | Prog Brain Res | 2011 | 1 |
| Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808] | Kunttas-Tatli E, Bose A, Kahali B, Bisho | Genesis | 2009 | 1 |
| CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970] | Lu W, Kawatani K, Ren Y | Alzheimers Res Ther | 2026 | 0 |
| Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536] | Zheng ZW, Min PX, Luo YL, Mao XF, Zhang | Neuron | 2026 | 0 |
| Presynaptic P/Q calcium channel deficit promotes postsynaptic excitability remod [PMID:41932329] | Thompson SJ, Miao QL, Sonig A, Noebels J | Neuron | 2026 | 0 |
| Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108] | Pruitt A, Yang L, Lee S, Balafkan N, Sea | bioRxiv : the preprint server | 2026 | 0 |
| Prenatal alcohol exposure dysregulates the expression of clock genes and alters [PMID:41086861] | Reina-Campos M, Gallego-Landin I, Medran | Open biology | 2025 | 0 |
| Sleep-improving effect and the potential mechanism of Morus alba L. on mice. [PMID:39255910] | Kong X, Zhou X, Li R, Kang Q, Hao L, Zhu | Fitoterapia | 2024 | 0 |
| Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098] | ["Oristrell J", "Oliva J", "Casado E", " | Journal of endocrinological in | 2022 | 0 |
| Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388] | Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y, | Seizure | 2022 | 0 |
| Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213] | ["Su Z", "Zhang K", "Kappel K", "Li S", | Nature | 2021 | 0 |
| Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341] | Rátkai A, Tárnok K, Aouad HE, Micska B, | Scientific reports | 2021 | 0 |
| Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196] | ["Zhu X", "Zhou B", "Pattni R", "Gleason | Nature neuroscience | 2021 | 0 |
| Prevalence and follow-up of potentially inappropriate medication and potentially [PMID:32641251] | ["van Loveren F", "van Berlo-van de Laar | Journal of geriatric oncology | 2021 | 0 |
| A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa [PMID:32047260] | ["Yan Y", "Shi K", "Teng F", "Chen J", " | Acta pharmacologica Sinica | 2020 | 0 |