gene

TPP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

212Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TPP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 98 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TPP1
Aliases	Page for TPP1 Gene, Tripeptidyl Peptidase 1
Chromosome	11p15.4
Protein Family	S9 family serine proteases
Function	It displays tripeptidyl-peptidase activity, cleaving N-terminal tripeptides from various substrates[1].
Molecular Weight	59 kDa
Amino Acids	563 aa
Exons	13
Pathways	Chaperone, Tdp-43, autophagy pathway, oxidative stress response
UniProt ID	O14773
NCBI Gene ID	1201
Ensembl ID	ENSG00000142149
OMIM	607998
GeneCards	TPP1
Human Protein Atlas	TPP1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	CALCINEURIN, ATG12, ATG10, LAMP1, LGALS3, STUB1
KG Connections	212 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TPP1 — AlphaFold O14773 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TPP1["TPP1"]
    TPP1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TPP1 -->|"interacts"| Als["Als"]
    TPP1 -->|"activates"| CALCINEURIN["CALCINEURIN"]
    TPP1 -->|"activates"| ATG12["ATG12"]
    TPP1 -->|"activates"| ATG10["ATG10"]
    TPP1 -->|"interacts"| Akt["Akt"]
    TPP1 -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    TPP1 -->|"activates"| GENES["GENES"]
    TPP1 -->|"expressed in"| Spinal_Cord["Spinal Cord"]
    TPP1 -->|"expressed in"| Neuron["Neuron"]
    GENES -->|"activates"| TPP1
    CALCINEURIN -->|"activates"| TPP1
    ATG12 -->|"activates"| TPP1
    POT1["POT1"] -->|"interacts"| TPP1
    TREHALOSE["TREHALOSE"] -->|"activates"| TPP1

Outgoing (101)

Target	Relation	Type	Str
blood-brain barrier	participates_in	pathway	0.70
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TREH	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
ATG10	activates	gene	0.60
LAMP1	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
TREH	activates	entity	0.60
P62	associated_with	gene	0.60
TDP-43	associated_with	gene	0.60
Neural Progenitor	associated_with	cell_type	0.60
neurodegeneration	activates	disease	0.60
cerebellum	expressed_in	brain_region	0.60
VEGFB	interacts_with	gene	0.60
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
DNA	associated_with	gene	0.60
Chaperone	associated_with	pathway	0.60
Akt	interacts_with	pathway	0.60
PPP3	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60

Incoming (111)

Source	Relation	Type	Str
STIP1	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BAG3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG12	activates	gene	0.60
GLA	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
POT1	interacts_with	gene	0.60
TREH	associated_with	gene	0.60
ATG10	activates	gene	0.60
ATG10	regulates	entity	0.60
ATG12	regulates	entity	0.60
BAG3	regulates	entity	0.60
BECN1	regulates	entity	0.60
CTSB	regulates	entity	0.60
GLA	regulates	entity	0.60
HSPB8	regulates	entity	0.60
LAMP2A	regulates	entity	0.60
MAP1LC3B	regulates	entity	0.60
MCOLN1	regulates	entity	0.60
P62	regulates	entity	0.60
PPARGC1A	regulates	entity	0.60
SQSTM1	regulates	entity	0.60
TFEB	regulates	entity	0.60
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
CTSB	activates	entity	0.60
GAPDH	activates	entity	0.60
GLA	activates	entity	0.60
HSPA8	activates	entity	0.60
HSPB8	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TPP1

Understanding Entity Pages

Summary

Wiki Pages (21)

TPP1 Gene - Tripeptidyl Peptidase 1

Neuronal Ceroid Lipofuscinosis (NCL)

Lysosomal Storage Disorders

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

CLN7 — Ceroid Lipofuscinosis, Neuronal 7 (MFSD8)

Section 135: Telomere Biology and Anti-Aging Interventions in CBS/PSP

CLN1 (PPT1) — Palmitoyl-Protein Thioesterase 1

Progressive Myoclonic Epilepsies (PME)

Cerliponase Alfa (Brineura) for CLN2 Disease

Telomere Dysfunction in Neurodegeneration

Microglia in Batten Disease

Batten Disease

Lysosomal Storage Disorders with Neurodegeneration Comparative Pathway

TINF2 Gene

Tectonin Beta-Propeller Repeat Containing 2

Ceroid Lipofuscinosis 2 (TPP1)

Abelson Helper Integration Site 1

Glutamate Decarboxylase 2

Glutamate Decarboxylase 1