concept

AQP5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AQP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

0Analyses

47Outgoing

21Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	AQP5
Key Genes/Proteins	HO-1, ASC, IL-6, TNF
Related Diseases	Inflammation, Pneumonia, Infection, Tumor, Alzheimer

Pathway Diagram

graph TD
    AQP5["AQP5"]
    AQP5 -->|"expressed in"| Central_Nervous_System["Central Nervous System"]
    AQP5 -->|"activates"| Inflammation["Inflammation"]
    AQP5 -->|"activates"| Pneumonia["Pneumonia"]
    AQP5 -->|"activates"| Infection["Infection"]
    AQP5 -->|"activates"| Tumor["Tumor"]
    AQP5 -->|"expressed in"| Alzheimer["Alzheimer"]
    AQP5 -->|"expressed in"| Cardiovascular["Cardiovascular"]
    AQP5 -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    INFLAMMATION["INFLAMMATION"] -->|"activates"| AQP5
    AND["AND"] -->|"activates"| AQP5
    NRF2["NRF2"] -->|"activates"| AQP5
    AQP3["AQP3"] -->|"activates"| AQP5
    MAPK["MAPK"] -->|"activates"| AQP5
    AQP4["AQP4"] -->|"activates"| AQP5
    GENES["GENES"] -->|"activates"| AQP5
    TLR4["TLR4"] -->|"activates"| AQP5

Outgoing (47)

Target	Relation	Type	Str
Central Nervous System	expressed_in	cell_type	0.90
Inflammation	activates	disease	0.65
Pneumonia	activates	disease	0.65
Infection	activates	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
HO-1	associated_with	gene	0.60
ASC	activates	gene	0.60
IL-6	associated_with	gene	0.60
TNF	associated_with	gene	0.60
Nlrp3 Inflammasome	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Mapk	activates	pathway	0.60
exocrine gland secretion	involved_in	biological_process	0.60
NEURODEGENERATION	expressed_in	gene	0.60
AQP9	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
AQP1	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AQP3	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AQP4	expressed_in	gene	0.60
AQP3	inhibits	gene	0.60
AQP1	associated_with	gene	0.60
Endothelial	inhibits	cell_type	0.60
Epithelial	inhibits	cell_type	0.60
AND	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
AQP1	transports	gene	0.60
AQP4	transports	gene	0.60
AQP3	transports	gene	0.60
Endothelial	transports	cell_type	0.60
Epithelial	transports	cell_type	0.60
CYTOKINES	inhibits	gene	0.60
Macrophage	inhibits	cell_type	0.60
INSR	biomarker_for	gene	0.60
LRP1	biomarker_for	gene	0.60
MUC1	biomarker_for	gene	0.60
OCLN	biomarker_for	gene	0.60
TJP1	biomarker_for	gene	0.60
Astrocyte	expressed_in	cell_type	0.55

Incoming (21)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	0.60
NLRP3	associated_with	gene	0.60
AND	activates	gene	0.60
NRF2	activates	gene	0.60
AQP3	activates	gene	0.60
MAPK	activates	gene	0.60
AQP4	activates	gene	0.60
GENES	activates	gene	0.60
TLR4	activates	gene	0.60
MYD88	activates	gene	0.60
TNF-Α	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
AQP4	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AQP1	expressed_in	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
AQP9	expressed_in	gene	0.60
AQP3	expressed_in	gene	0.60
AQP3	inhibits	gene	0.60
AQP1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found