concept

PI3K/AKT SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

130Connections

0Hypotheses

0Analyses

9Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PI3K/AKT SIGNALING
Key Genes/Proteins	PI3K, AKT, GLUT1, PKM2, HIF-1Α, Proteins
Related Pathways	Pi3K, Pi3K/Akt

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PI3K_AKT_SIGNALING["PI3K/AKT SIGNALING"]
    PI3K_AKT_SIGNALING -->|"downregulates"| MHC_I["MHC-I"]
    PI3K_AKT_SIGNALING -->|"involved_in"| Dermatomyositis["Dermatomyositis"]
    PI3K_AKT_SIGNALING -->|"activates"| Primordial_Follicle_Activation["Primordial Follicle Activation"]
    PI3K_AKT_SIGNALING -->|"activates"| ROS["ROS"]
    PI3K_AKT_SIGNALING -->|"activates"| TREM2["TREM2"]
    PI3K_AKT_SIGNALING -->|"activates"| SEPSIS["SEPSIS"]
    PI3K_AKT_SIGNALING -->|"activates"| QUERCETIN["QUERCETIN"]
    G3BP1["G3BP1"] -->|"activates"| PI3K_AKT_SIGNALING
    class_IA_PI3Ks["class IA PI3Ks"] -->|"activates"| PI3K_AKT_SIGNALING
    Juvenile_Dermatomyositis["Juvenile Dermatomyositis"] -->|"involved_in"| PI3K_AKT_SIGNALING
    PTEN["PTEN"] -->|"inhibits"| PI3K_AKT_SIGNALING
    curcumin["curcumin"] -->|"activates"| PI3K_AKT_SIGNALING
    BDNF["BDNF"] -->|"activates"| PI3K_AKT_SIGNALING
    ERBB2["ERBB2"] -->|"downregulates"| PI3K_AKT_SIGNALING

Outgoing (12)

Target	Relation	Type	Str
SRPK1	associated_with	concept	0.50
TP53	regulates	gene	0.45
ROS	activates	protein	0.35
TREM2	activates	gene	0.35
SEPSIS	activates	disease	0.35
SEPSIS	therapeutic_target	disease	0.35
QUERCETIN	activates	drug	0.35
TAU	phosphorylates	protein	0.30
RB1	activates	gene	0.30

Incoming (118)

Source	Relation	Type	Str
PI3K	activates	gene	0.65
AKT	activates	gene	0.65
Pi3K	activates	pathway	0.50
GLUT1	activates	protein	0.50
PKM2	activates	protein	0.50
HIF-1Α	activates	protein	0.50
MTORC1	activates	concept	0.50
Pi3K/Akt	activates	pathway	0.50
Proteins	activates	protein	0.50
GSK3	activates	concept	0.50
ANGPT1	activates	concept	0.50
AMYLOID	activates	gene	0.50
Pi3K	expressed_in	pathway	0.50
Pi3K/Akt	expressed_in	pathway	0.50
ENDOTHELIAL	activates	concept	0.50
Sepsis	activates	disease	0.50
Cognitive Impairment	activates	phenotype	0.50
Pi3K	associated_with	pathway	0.50
Pi3K/Akt	associated_with	pathway	0.50
ENDOTHELIAL	associated_with	concept	0.50
Sepsis	associated_with	disease	0.50
Pi3K	regulates	pathway	0.50
inflammation	regulates	pathway	0.50
Pi3K/Akt	regulates	pathway	0.50
disease	regulates	disease	0.50
Fatty Liver	regulates	disease	0.50
mitophagy	activates	pathway	0.50
CARCINOMA	activates	disease	0.50
apoptosis	activates	process	0.50
QUERCETIN	activates	concept	0.50
Pi3K	inhibits	pathway	0.50
apoptosis	inhibits	process	0.50
Pi3K/Akt	inhibits	pathway	0.50
Pi3K	interacts_with	pathway	0.50
AMYLOID	interacts_with	gene	0.50
Pi3K/Akt	interacts_with	pathway	0.50
oxidative stress	inhibits	phenotype	0.50
ferroptosis	inhibits	phenotype	0.50
Pi3K	protects_against	pathway	0.50
oxidative stress	protects_against	phenotype	0.50
ferroptosis	protects_against	phenotype	0.50
Pi3K/Akt	protects_against	pathway	0.50
mTOR	associated_with	entity	0.50
MAPK	associated_with	gene	0.50
EGFR	expressed_in	gene	0.50
PIK3CA	expressed_in	gene	0.50
MAPK1	expressed_in	gene	0.50
PIK3R1	expressed_in	gene	0.50
JAK2	expressed_in	gene	0.50
HRAS	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PI3K/AKT SIGNALING

Understanding Entity Pages

Wiki Pages (20)

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