concept

NEUTROPHILS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUTROPHILS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

154Connections

0Hypotheses

0Analyses

31Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NEUTROPHILS
Key Genes/Proteins	APOE ε4, APOE4, CYTOKINES
Related Diseases	NET, STROKE, CYTOKINES, COPD, ALZHEIMER'S DISEASE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NEUTROPHILS["NEUTROPHILS"]
    NEUTROPHILS -->|"interacts"| Microglia["Microglia"]
    NEUTROPHILS -->|"expressed in"| IL_17_Signaling_Pathway["IL-17 Signaling Pathway"]
    NEUTROPHILS -->|"expressed in"| IL_17["IL-17"]
    NEUTROPHILS -->|"produces"| NET["NET"]
    NEUTROPHILS -->|"contributes to"| atherosclerosis["atherosclerosis"]
    NEUTROPHILS -->|"activates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    NEUTROPHILS -->|"inhibits"| SPINAL_CORD_INJURY["SPINAL CORD INJURY"]
    NEUTROPHILS -->|"inhibits"| SPINAL_CORD["SPINAL CORD"]
    Neutrophil_Extracellular_Traps["Neutrophil Extracellular Traps"] -->|"expressed in"| NEUTROPHILS
    SEMA3F["SEMA3F"] -->|"upregulates"| NEUTROPHILS
    MACROPHAGES["MACROPHAGES"] -->|"interacts"| NEUTROPHILS
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| NEUTROPHILS
    CYTOKINES["CYTOKINES"] -->|"activates"| NEUTROPHILS
    CD47["CD47"] -->|"inhibits"| NEUTROPHILS
    LUPUS["LUPUS"] -->|"activates"| NEUTROPHILS

Outgoing (40)

Target	Relation	Type	Str
NET	produces	phenotype	0.72
STROKE	treats	disease	0.65
CYTOKINES	produces	phenotype	0.65
COPD	expressed_in	disease	0.55
PHAGOCYTOSIS	activates	process	0.50
SPINAL CORD INJURY	associated_with	concept	0.50
IL-17	expressed_in	concept	0.50
DENDRITIC CELLS	activates	concept	0.50
DENDRITIC CELLS	associated_with	concept	0.50
SPINAL CORD INJURY	inhibits	disease	0.35
SPINAL CORD	inhibits	brain_region	0.35
SPINAL CORD INJURY	contributes_to	disease	0.35
NRF2	activates	gene	0.35
SIRT6	contributes_to	gene	0.35
SEPSIS	expressed_in	disease	0.35
PI3K	therapeutic_target	gene	0.35
TLR4	protects_against	gene	0.35
TNF	activates	gene	0.35
NF-KB	activates	gene	0.35
PANCREATITIS	inhibits	disease	0.35
SPINAL CORD	activates	brain_region	0.35
ROS	activates	protein	0.35
T CELLS	interacts_with	cell_type	0.35
STEM CELLS	activates	cell_type	0.35
T CELLS	activates	cell_type	0.35
NLRP3	activates	gene	0.35
TRAUMATIC BRAIN INJURY	activates	disease	0.35
TRAUMATIC BRAIN INJURY	associated_with	disease	0.35
TRAUMATIC BRAIN INJURY	regulates	disease	0.35
TRAUMATIC BRAIN INJURY	interacts_with	disease	0.35
OLIGODENDROCYTES	regulates	cell_type	0.35

Incoming (114)

Source	Relation	Type	Str
APOE ε4	interacts_with	gene	0.90
APOE4	interacts_with	gene	0.90
MACROPHAGES	interacts_with	cell_type	0.80
MACROPHAGES	activates	cell_type	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.50
CYTOKINES	activates	protein	0.50
Spinal Cord	associated_with	cell_type	0.50
NEUTROPHIL	associated_with	cell_type	0.50
NRF2	activates	gene	0.50
HO-1	activates	protein	0.50
CARCINOMA	activates	disease	0.50
ferroptosis	activates	phenotype	0.50
disease	activates	disease	0.50
Lupus	activates	disease	0.50
Nephropathy	activates	disease	0.50
Renal Cell Carcinoma	activates	disease	0.50
PHAGOCYTOSIS	activates	gene	0.50
GPR37	activates	gene	0.50
Pain	activates	disease	0.50
inflammation	inhibits	pathway	0.50
DIABETES	inhibits	disease	0.50
Macrophage	inhibits	cell_type	0.50
MACROPHAGES	inhibits	concept	0.50
NEUTROPHIL	inhibits	cell_type	0.50
NEUTROPHIL	activates	cell_type	0.50
NEUTROPHIL	interacts_with	cell_type	0.50
TLR4	inhibits	gene	0.50
TLR9	inhibits	gene	0.50
APOE4	inhibits	gene	0.50
APOE	inhibits	gene	0.50
microglia	inhibits	cell_type	0.50
Cognitive Impairment	inhibits	phenotype	0.50
APOE	activates	gene	0.50
microglia	activates	cell_type	0.50
IL-1	activates	concept	0.50
NEUTROPHIL	expressed_in	cell_type	0.50
IMMUNE INFILTRATION	activates	concept	0.50
ALZHEIMER	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
Macrophage	activates	cell_type	0.50
MONOCYTE	activates	concept	0.50
MONOCYTES	associated_with	concept	0.50
MONOCYTES	interacts_with	concept	0.50
SMPD1	associated_with	gene	0.50
ISCHEMIA	associated_with	disease	0.50
B Cell	activates	cell_type	0.50
T CELLS	activates	concept	0.50
STEM CELLS	activates	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NEUTROPHILS

Understanding Entity Pages

Wiki Pages (20)

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

neuroinflammation

Astrocyte Reactivity Mechanism

omega-3-fatty-acids-neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

Multiple Sclerosis (MS)

NF-kB Signaling Pathway in Neurodegeneration

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

Neuroinflammation in Amyotrophic Lateral Sclerosis

Blood-Brain Barrier Breakdown in Neurodegeneration

Neuroinflammation in Parkinson's Disease

cGAS-STING Signaling in Parkinson's Disease

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Reactive Oxygen Species (ROS) Pathway

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Flotillin-1 Protein

IL32