cell_type

NEUTROPHIL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUTROPHIL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

430Connections

0Hypotheses

1Analyses

46Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	NEUTROPHIL
Related Genes	ROS, APOE, APOE4, NRF2, SIRT6
Linked Hypotheses	19 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NEUTROPHIL["NEUTROPHIL"] -->|"increases"| T_CELL["T CELL"]
    style T_CELL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"increases"| T_CELLS["T CELLS"]
    style T_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"treats"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"increases"| SPINAL_CORD["SPINAL CORD"]
    style SPINAL_CORD fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"causes"| LUNG_INFLAMMATION["LUNG_INFLAMMATION"]
    style LUNG_INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"regulates"| NRF2["NRF2"]
    style NRF2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"activates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    style PHAGOCYTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    AGING["AGING"] -->|"interacts"| NEUTROPHIL["NEUTROPHIL"]
    style AGING fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    APOE["APOE"] -->|"interacts"| NEUTROPHIL["NEUTROPHIL"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APOE4["APOE4"] -->|"interacts"| NEUTROPHIL["NEUTROPHIL"]
    style APOE4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MICROGLIA["MICROGLIA"] -->|"expressed in"| NEUTROPHIL["NEUTROPHIL"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    B_CELL["B CELL"] -->|"increases"| NEUTROPHIL["NEUTROPHIL"]
    style B_CELL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEUTROPHIL fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (53)

Target	Relation	Type	Str
T CELL	increases	cell_type	0.65
T CELLS	increases	cell_type	0.65
PI3K	treats	gene	0.65
SPINAL CORD	increases	brain_region	0.65
SPINAL CORD	inhibits	brain_region	0.65
ROS	activates	gene	0.65
T CELL	contributes_to	cell_type	0.65
LUNG_INFLAMMATION	causes	phenotype	0.64
SPINAL CORD	impairs	brain_region	0.60
NRF2	regulates	gene	0.60
SIRT6	exacerbates	gene	0.60
TNF	activates	gene	0.60
TUMOR	activates	disease	0.60
STROKE	interacts_with	disease	0.60
NLRP3	activates	gene	0.60
TBI	mediates	disease	0.60
TBI	associated_with	disease	0.60
TBI	causes	disease	0.60
SPINAL CORD INJURY	inhibits	concept	0.50
NEUTROPHILS	associated_with	concept	0.50
SPINAL CORD INJURY	associated_with	concept	0.50
NEUTROPHILS	inhibits	concept	0.50
NEUTROPHILS	activates	concept	0.50
MAPK SIGNALING	associated_with	concept	0.50
NEUTROPHILS	interacts_with	concept	0.50
NUCLEUS	regulates	concept	0.50
IL-17	activates	concept	0.50
Pain	interacts_with	disease	0.50
IL-1	activates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
FIBROBLASTS	activates	concept	0.50
B CELLS	activates	concept	0.50
NEUTROPHILS	expressed_in	concept	0.50
IL-17	expressed_in	concept	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
NEUTROPHILS	regulates	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
SPINAL CORD	co_discussed	brain_region	0.40
PI3K	co_discussed	gene	0.40
TLR4	co_discussed	gene	0.40
STROKE	co_discussed	disease	0.40
T CELL	co_discussed	cell_type	0.40
T CELLS	co_discussed	cell_type	0.40
TBI	co_discussed	disease	0.40
OLIGODENDROCYTE	co_discussed	cell_type	0.40
OLIGODENDROCYTES	co_discussed	cell_type	0.40

Incoming (377)

Source	Relation	Type	Str
APOE	interacts_with	gene	0.65
APOE4	interacts_with	gene	0.65
APOE	expressed_in	gene	0.65
MICROGLIA	expressed_in	cell_type	0.65
B CELL	increases	cell_type	0.65
ENDOTHELIAL	increases	cell_type	0.65
MACROPHAGE	increases	cell_type	0.65
MACROPHAGES	increases	cell_type	0.65
MENINGITIS	accumulates_in	disease	0.65
MONOCYTE	accumulates_in	cell_type	0.65
MONOCYTES	accumulates_in	cell_type	0.65
MONOCYTE	interacts_with	cell_type	0.65
MONOCYTES	interacts_with	cell_type	0.65
AKT	treats	gene	0.65
MAPK	treats	gene	0.65
MAST CELL	contributes_to	cell_type	0.65
CARCINOMA	causes	disease	0.60
DIABETES	exacerbates	disease	0.60
MACROPHAGE	exacerbates	cell_type	0.60
MACROPHAGES	exacerbates	cell_type	0.60
MOTOR NEURON	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
MACROPHAGE	interacts_with	cell_type	0.60
MICROGLIA	inhibits	cell_type	0.60
MICROGLIA	activates	cell_type	0.60
ISCHEMIC	exacerbates	disease	0.60
MICROGLIA	exacerbates	cell_type	0.60
ISCHEMIC	interacts_with	disease	0.60
MICROGLIA	interacts_with	cell_type	0.60
CANCER	treats	disease	0.60
APOE	impairs	gene	0.60
MICROGLIA	impairs	cell_type	0.60
MACROPHAGE	activates	cell_type	0.60
SYMPATHETIC_NERVE	activates	cell_type	0.56
CD47	inhibits	protein	0.50
Spinal Cord	inhibits	cell_type	0.50
Spinal Cord	associated_with	cell_type	0.50
inflammation	inhibits	pathway	0.50
DIABETES	inhibits	disease	0.50
Macrophage	inhibits	cell_type	0.50
MACROPHAGES	inhibits	concept	0.50
SIRT6	associated_with	gene	0.50
inflammation	associated_with	pathway	0.50
Macrophage	associated_with	cell_type	0.50
MACROPHAGES	associated_with	concept	0.50
Sepsis	expressed_in	disease	0.50
EXERCISE	inhibits	concept	0.50
EXERCISE	activates	concept	0.50
Pi3K	associated_with	pathway	0.50
MAPK	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NEUTROPHIL

Understanding Entity Pages

Wiki Pages (20)

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

neuroinflammation

Astrocyte Reactivity Mechanism

omega-3-fatty-acids-neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

Multiple Sclerosis (MS)

NF-kB Signaling Pathway in Neurodegeneration

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

Neuroinflammation in Amyotrophic Lateral Sclerosis

Blood-Brain Barrier Breakdown in Neurodegeneration

Neuroinflammation in Parkinson's Disease

cGAS-STING Signaling in Parkinson's Disease

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Reactive Oxygen Species (ROS) Pathway

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Flotillin-1 Protein

IL32

Spinal Cord Injury