gene

EBF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EBF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

17Outgoing

9Incoming

Summary

Comprehensive gene page for EBF3 (Early B-cell Factor 3), a transcription factor critical for neuronal development, synapse formation, and cognitive function

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🧬 Gene Info

Gene Symbol	EBF3
Full Name	Early B-cell Factor 3
Primary Expression	mature neurons, where it contributes to synaptic plasticity and cognitive function[@coe2019][@ebf2020]
Molecular Weight	65 kDa
Pathways	Dna Methylation, Epigenetic
Ensembl ID	ENSG00000108001
GeneCards	EBF3
Human Protein Atlas	EBF3
Direct DNA Binding	Binds to specific palindromic sequences in target gene promoters and enhancers
Chromatin Remodeling	Recruits chromatin-modifying enzymes to open or close chromatin
Transcriptional Activation/Repression	Can both activate and repress target genes depending on context
Protein Complex Formation	Forms homodimers and heterodimers with other COE proteins
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	26 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EBF3["<b>EBF3</b>"]
    Glioblastoma{"Glioblastoma"}
    EBF3 -->|"regulates"| Glioblastoma
    Als{"Als"}
    EBF3 -->|"regulates"| Als
    Ms{"Ms"}
    EBF3 -->|"regulates"| Ms
    MYC["MYC"]
    EBF3 -->|"regulates"| MYC
    P53["P53"]
    EBF3 -->|"regulates"| P53
    TP53["TP53"]
    EBF3 -->|"regulates"| TP53
    MDM2["MDM2"]
    EBF3 -->|"regulates"| MDM2
    GBM["GBM"]
    EBF3 -->|"regulates"| GBM
    Dna_Methylation(["Dna Methylation"])
    EBF3 -->|"regulates"| Dna_Methylation
    Epigenetic(["Epigenetic"])
    EBF3 -->|"regulates"| Epigenetic
    GENES["GENES"]
    EBF3 -->|"regulates"| GENES
    RB1["RB1"]
    EBF3 -->|"associated with"| RB1
    CDK4["CDK4"]
    CDK4 -->|"regulates"| EBF3
    RB1 -->|"associated with"| EBF3
    GENES -->|"regulates"| EBF3
    DNA["DNA"]
    DNA -->|"regulates"| EBF3
    MDM2 -->|"regulates"| EBF3
    TP53 -->|"regulates"| EBF3
    P53 -->|"regulates"| EBF3
    MYC -->|"regulates"| EBF3
    GBM -->|"regulates"| EBF3
    style EBF3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
Glioblastoma	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
MYC	regulates	gene	0.60
TP53	regulates	gene	0.60
MDM2	regulates	gene	0.60
GBM	regulates	gene	0.60
RB1	associated_with	gene	0.60
CDK4	regulates	gene	0.60
P53	regulates	gene	0.60
Dna Methylation	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
GENES	regulates	gene	0.60
DNA	regulates	gene	0.60
GLIOBLASTOMA	regulates	gene	0.60
glioblastoma	regulates	disease	0.60
stem cells	expressed_in	cell_type	0.55

Incoming (9)

Source	Relation	Type	Str
CDK4	regulates	gene	0.60
RB1	associated_with	gene	0.60
MDM2	regulates	gene	0.60
TP53	regulates	gene	0.60
MYC	regulates	gene	0.60
GBM	regulates	gene	0.60
GENES	regulates	gene	0.60
DNA	regulates	gene	0.60
P53	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found