Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GASDERMIN D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GASDERMIN D |
| Molecular Weight | 52.8 kDa |
| Amino Acids | 487 aa |
| Pathways | Pyroptosis, Nlrp3 Inflammasome, inflammation, Necroptosis |
| Associated Diseases | ferroptosis |
| Interactions | NLRP3, GASDERMIN, CASPASE-1, ALZHEIMER, IL-1Β, GSDMD |
| KG Connections | 53 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GASDERMIN_D["<b>GASDERMIN D</b>"]
NLRP3["NLRP3"]
GASDERMIN_D -->|"activates"| NLRP3
INFLAMMASOME["INFLAMMASOME"]
GASDERMIN_D -->|"activates"| INFLAMMASOME
NEUROTOXICITY["NEUROTOXICITY"]
GASDERMIN_D -->|"activates"| NEUROTOXICITY
GASDERMIN["GASDERMIN"]
GASDERMIN_D -->|"activates"| GASDERMIN
NLRP3["NLRP3"]
GASDERMIN_D -->|"regulates"| NLRP3
INFLAMMASOME["INFLAMMASOME"]
GASDERMIN_D -->|"regulates"| INFLAMMASOME
Pyroptosis["Pyroptosis"]
GASDERMIN_D -->|"regulates"| Pyroptosis
Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
GASDERMIN_D -->|"regulates"| Nlrp3_Inflammasome
GASDERMIN["GASDERMIN"]
GASDERMIN_D -->|"regulates"| GASDERMIN
Proteins["Proteins"]
GASDERMIN_D -->|"regulates"| Proteins
TEMPORAL_LOBE["TEMPORAL LOBE"]
GASDERMIN_D -->|"regulates"| TEMPORAL_LOBE
CASPASE_1["CASPASE-1"]
GASDERMIN_D -->|"activates"| CASPASE_1
inflammation["inflammation"]
GASDERMIN_D -->|"activates"| inflammation
ALZHEIMER["ALZHEIMER"]
GASDERMIN_D -->|"activates"| ALZHEIMER
Alzheimer_S_Disease["Alzheimer'S Disease"]
GASDERMIN_D -->|"activates"| Alzheimer_S_Disease
CYTOKINES["CYTOKINES"]
GASDERMIN_D -->|"activates"| CYTOKINES
Pyroptosis["Pyroptosis"]
GASDERMIN_D -->|"activates"| Pyroptosis
PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
GASDERMIN_D -->|"activates"| PROINFLAMMATORY_CYTOKINES
disease["disease"]
GASDERMIN_D -->|"activates"| disease
ALZHEIMER_S["ALZHEIMER'S"]
GASDERMIN_D -->|"activates"| ALZHEIMER_S
apoptosis["apoptosis"]
GASDERMIN_D -->|"activates"| apoptosis
Necroptosis["Necroptosis"]
GASDERMIN_D -->|"activates"| Necroptosis
Melanoma["Melanoma"]
GASDERMIN_D -->|"activates"| Melanoma
atherosclerosis["atherosclerosis"]
GASDERMIN_D -->|"inhibits"| atherosclerosis
Pyroptosis["Pyroptosis"]
GASDERMIN_D -->|"inhibits"| Pyroptosis
Macrophage["Macrophage"]
GASDERMIN_D -->|"inhibits"| Macrophage
MACROPHAGES["MACROPHAGES"]
GASDERMIN_D -->|"inhibits"| MACROPHAGES
GASDERMIN["GASDERMIN"]
GASDERMIN_D -->|"inhibits"| GASDERMIN
NLRP3["NLRP3"]
GASDERMIN_D -->|"associated with"| NLRP3
INFLAMMASOME["INFLAMMASOME"]
GASDERMIN_D -->|"associated with"| INFLAMMASOME| Target | Relation | Type | Str |
|---|---|---|---|
| NLRP3 | activates | protein | 0.50 |
| NEUROTOXICITY | activates | concept | 0.50 |
| GASDERMIN | activates | gene | 0.50 |
| NLRP3 | regulates | protein | 0.50 |
| Pyroptosis | regulates | pathway | 0.50 |
| Nlrp3 Inflammasome | regulates | pathway | 0.50 |
| GASDERMIN | regulates | gene | 0.50 |
| Proteins | regulates | protein | 0.50 |
| TEMPORAL LOBE | regulates | concept | 0.50 |
| CASPASE-1 | activates | protein | 0.50 |
| inflammation | activates | pathway | 0.50 |
| ALZHEIMER | activates | gene | 0.50 |
| Alzheimer'S Disease | activates | disease | 0.50 |
| CYTOKINES | activates | concept | 0.50 |
| Pyroptosis | activates | pathway | 0.50 |
| PROINFLAMMATORY CYTOKINES | activates | concept | 0.50 |
| disease | activates | disease | 0.50 |
| ALZHEIMER'S | activates | concept | 0.50 |
| apoptosis | activates | process | 0.50 |
| Necroptosis | activates | pathway | 0.50 |
| Melanoma | activates | disease | 0.50 |
| atherosclerosis | inhibits | disease | 0.50 |
| Pyroptosis | inhibits | pathway | 0.50 |
| Macrophage | inhibits | cell_type | 0.50 |
| MACROPHAGES | inhibits | concept | 0.50 |
| GASDERMIN | inhibits | gene | 0.50 |
| NLRP3 | associated_with | protein | 0.50 |
| Nlrp3 Inflammasome | associated_with | pathway | 0.50 |
| GASDERMIN | associated_with | gene | 0.50 |
| CELL DEATH | associated_with | concept | 0.50 |
| CYTOKINE | associated_with | concept | 0.50 |
| CASPASE-1 | associated_with | protein | 0.50 |
| ferroptosis | associated_with | phenotype | 0.50 |
| Pyroptosis | associated_with | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | activates | disease | 0.50 |
| IL-1Β | activates | protein | 0.50 |
| GSDMD | regulates | protein | 0.50 |
| GSDMD | activates | protein | 0.50 |
| AIM2 | activates | gene | 0.50 |
| MLKL | activates | gene | 0.50 |
| ZBP1 | activates | gene | 0.50 |
| GSDMD | inhibits | protein | 0.50 |
| TGM2 | associated_with | gene | 0.50 |
| GSDMD | associated_with | protein | 0.50 |
| IL-1Β | associated_with | protein | 0.50 |
| microglia | activates | cell_type | 0.50 |
| RIPK1 | activates | gene | 0.50 |
| MYD88 | activates | gene | 0.50 |
| INPP5D | activates | gene | 0.50 |
| BDNF | associated_with | gene | 0.50 |
| GPX4 | associated_with | gene | 0.50 |
| GFAP | associated_with | gene | 0.50 |
| CREB | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||