GCLM

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCLM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for GCLM — Glutamate-Cysteine Ligase Modifier Subunit

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graph TD
    GCLM["<b>GCLM</b>"]
    Inflammation{"Inflammation"}
    GCLM -->|"biomarker for"| Inflammation
    GCLM -->|"associated with"| Inflammation
    GCLC["GCLC"]
    GCLM -->|"regulates"| GCLC
    Oxidative_Stress(["Oxidative Stress"])
    GCLM -->|"biomarker for"| Oxidative_Stress
    HMOX1["HMOX1"]
    GCLM -->|"regulates"| HMOX1
    GENES["GENES"]
    GCLM -->|"biomarker for"| GENES
    NRF2["NRF2"]
    GCLM -->|"regulates"| NRF2
    TXNRD1["TXNRD1"]
    GCLM -->|"regulates"| TXNRD1
    SRXN1["SRXN1"]
    GCLM -->|"regulates"| SRXN1
    NQO1["NQO1"]
    GCLM -->|"regulates"| NQO1
    GCLM -->|"associated with"| Oxidative_Stress
    INFLAMMATION["INFLAMMATION"]
    GCLM -->|"biomarker for"| INFLAMMATION
    NRF2 -->|"regulates"| GCLM
    NQO1 -->|"regulates"| GCLM
    HMOX1 -->|"regulates"| GCLM
    TXNRD1 -->|"regulates"| GCLM
    GCLC -->|"regulates"| GCLM
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"biomarker for"| GCLM
    AND["AND"]
    AND -->|"regulates"| GCLM
    GENES -->|"biomarker for"| GCLM
    INFLAMMATION -->|"biomarker for"| GCLM
    style GCLM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0