gene

TXNRD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TXNRD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

126Connections

0Hypotheses

0Analyses

50Outgoing

34Incoming

Summary

TXNRD1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Depression, Diabetes, Inflammation. Connected to 91 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TXNRD1
Full Name	Thioredoxin Reductase 1
Chromosome	12q23.3
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	500 aa
Pathways	Dna Methylation
UniProt ID	Q16881
NCBI Gene ID	7296
Ensembl ID	ENSG00000198431
GeneCards	TXNRD1
Human Protein Atlas	TXNRD1
Associated Diseases	ALS, Alzheimer, Inflammation, Macular Degeneration, depression
Interactions	APP, TAU, TRKB, BDNF, TPH2, NGF
KG Connections	126 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TXNRD1 — AlphaFold Q16881 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TXNRD1["TXNRD1"] -->|"biomarker for"| Inflammation["Inflammation"]
    TXNRD1["TXNRD1"] -->|"associated"| Inflammation_1["Inflammation"]
    TXNRD1["TXNRD1"] -->|"activates"| Inflammation_2["Inflammation"]
    TXNRD1["TXNRD1"] -->|"activates"| Diabetes["Diabetes"]
    TXNRD1["TXNRD1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TXNRD1["TXNRD1"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    NRF2["NRF2"] -->|"regulates"| TXNRD1["TXNRD1"]
    NQO1["NQO1"] -->|"regulates"| TXNRD1["TXNRD1"]
    HMOX1["HMOX1"] -->|"regulates"| TXNRD1["TXNRD1"]
    GCLC["GCLC"] -->|"regulates"| TXNRD1["TXNRD1"]
    style TXNRD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (92)

Target	Relation	Type	Str
Inflammation	biomarker_for	disease	0.65
Inflammation	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Diabetes	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Depression	activates	disease	0.65
Ms	activates	disease	0.65
Ms	inhibits	disease	0.65
Macular Degeneration	causes	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
NRF2	regulates	gene	0.60
GCLM	regulates	gene	0.60
GCLC	regulates	gene	0.60
MFN2	regulates	gene	0.60
UNG	associated_with	gene	0.60
SDHB	regulates	gene	0.60
APP	activates	gene	0.60
TAU	activates	gene	0.60
TRKB	activates	gene	0.60
BDNF	activates	gene	0.60
TPH2	activates	gene	0.60
NGF	activates	gene	0.60
NFATC1	activates	gene	0.60
SLC7A11	activates	gene	0.60
AKT	activates	gene	0.60
PTEN	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
HMOX1	regulates	gene	0.60
NQO1	regulates	gene	0.60
NFE2L2	activates	gene	0.60
DDX3X	expressed_in	gene	0.60
HSPG2	expressed_in	gene	0.60
Rb	expressed_in	protein	0.60
depression	associated_with	disease	0.60
Oxidative Stress	biomarker_for	pathway	0.60
SRXN1	regulates	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
Dna Methylation	regulates	pathway	0.60
Complement	associated_with	pathway	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
HO-1	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mapk	activates	pathway	0.60
FERROPTOSIS	inhibits	gene	0.60

Incoming (34)

Source	Relation	Type	Str
NRF2	regulates	protein	0.72
NQO1	regulates	gene	0.60
HMOX1	regulates	gene	0.60
GCLC	regulates	gene	0.60
GCLM	regulates	gene	0.60
STX17	associated_with	gene	0.60
ATP5MC1	regulates	gene	0.60
SIRT3	activates	gene	0.60
RANKL	inhibits	gene	0.60
NFE2L2	activates	gene	0.60
PI3K	activates	gene	0.60
PTEN	causes	gene	0.60
PINK1	causes	gene	0.60
AKT	activates	gene	0.60
HSPG2	expressed_in	gene	0.60
DDX3X	expressed_in	gene	0.60
TPH2	activates	gene	0.60
NGF	activates	gene	0.60
HSPG2	associated_with	gene	0.60
GENES	biomarker_for	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PHAGOCYTOSIS	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
AUTOPHAGY	causes	gene	0.60
MITOPHAGY	causes	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
DEPRESSION	activates	gene	0.60
NAD	activates	gene	0.60
GENES	expressed_in	gene	0.60
SRXN1	regulates	gene	0.60
DDX3X	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TXNRD1

Understanding Entity Pages

Summary

Wiki Pages (14)

TXNRD1 — Thioredoxin Reductase 1

KEAP1 Protein

NRF2 Activators for Parkinson's Disease

UNG Gene

Nrf2 Activators for Neurodegenerative Diseases

Evgen Pharma plc

NRF2 — Nuclear Factor Erythroid 2-Related Factor 2

gclc

NFE2L1 — Nuclear Factor Erythroid 2-Like 1

NRF2-KEAP1 Oxidative Stress Response Pathway

GCLM — Glutamate-Cysteine Ligase Modifier Subunit

TXNRD1 Protein