gene

HTRA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTRA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

265Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HTRA2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, inhibits, associated with. Associated with Als, Heart Failure, Hepatitis. Connected to 147 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HTRA2
Full Name	HtrA Serine Peptidase 2
Aliases	HtrA2 / Omi
Chromosome	2p13.1
Protein Type	Protease
Function	is a nuclear-encoded mitochondrial serine protease that plays critical roles in cellular protein quality control and apoptosis regulation[@ncbi].
Primary Expression	regions vulnerable to neurodegenerative processes[@strauss2005]:
Subcellular Localization	Mitochondrial intermembrane space
Molecular Weight	48 kDa (precursor), 35 kDa (active protease)
Amino Acids	458 aa
Exons	8
Pathways	Autophagy, Cholesterol, Oxidative Stress
UniProt ID	O43464
NCBI Gene ID	27429
Ensembl ID	ENSG00000103472
OMIM	606476
GeneCards	HTRA2
Human Protein Atlas	HTRA2
Associated Diseases	Infection, Inflammation, Sepsis
Known Drugs/Compounds	rapamycin
Interactions	MTOR, SIRT3, PLIN2, TP53, ULK1, PRKAA2
KG Connections	265 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HTRA2 — AlphaFold O43464 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HTRA2["HTRA2"]
    HTRA2 -->|"interacts"| Tumor["Tumor"]
    HTRA2 -->|"interacts"| Hepatitis["Hepatitis"]
    HTRA2 -->|"activates"| Als["Als"]
    HTRA2 -->|"activates"| Ms["Ms"]
    HTRA2 -->|"inhibits"| Heart_Failure["Heart Failure"]
    HTRA2 -->|"interacts"| MTOR["MTOR"]
    HTRA2 -->|"interacts"| SIRT3["SIRT3"]
    HTRA2 -->|"interacts"| PLIN2["PLIN2"]
    HTRA2 -->|"interacts"| TP53["TP53"]
    PPARA["PPARA"] -->|"interacts"| HTRA2
    ULK1["ULK1"] -->|"interacts"| HTRA2
    STX17["STX17"] -->|"interacts"| HTRA2
    SQSTM1["SQSTM1"] -->|"interacts"| HTRA2
    NOS3["NOS3"] -->|"interacts"| HTRA2
    STING1["STING1"] -->|"interacts"| HTRA2
    GLP1R["GLP1R"] -->|"interacts"| HTRA2
    SREBF1["SREBF1"] -->|"interacts"| HTRA2
    SIRT1["SIRT1"] -->|"interacts"| HTRA2
    KDM6B["KDM6B"] -->|"interacts"| HTRA2

Outgoing (156)

Target	Relation	Type	Str
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
SMAC	interacts_with	gene	0.60
LC3	activates	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
TFEB	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
AIM2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
CHMP7	associated_with	gene	0.60
CD8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PRKACA	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
CD4	associated_with	gene	0.60
GCLM	associated_with	gene	0.60
KDM6B	activates	entity	0.60

Incoming (109)

Source	Relation	Type	Str
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
UBIQUITIN	activates	gene	0.60
DIABLO	activates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HTRA2

Understanding Entity Pages

Summary

Wiki Pages (21)

HTRA2 Gene

Mitochondria in Neurodegeneration

Cytochrome c Protein

Apoptosis Pathway in Neurodegeneration

Apoptosis in Neurodegeneration

PINK1-Parkin Mitophagy Complex

HTRA2 Protein

DIABLO

HSPE1 — Heat Shock Protein Family E Member 1

PINK1/PARKIN Mitophagy Activators for Parkinson's Disease

Apoptosis Pathways in Alzheimer's Disease

GRK2 — G Protein-Coupled Receptor Kinase 2

AFG3L2 Gene

LONP1

Preoptic Area Neurons

ENDOG

TIMM22 Protein

Preoptic Sleep-Active Neurons

YME1L1 Protein