gene

HTRA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTRA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

264Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HTRA2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, inhibits, associated with. Associated with Als, Heart Failure, Hepatitis. Connected to 147 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HTRA2
Full Name	HtrA Serine Peptidase 2
Aliases	HtrA2 / Omi
Chromosome	2p13.1
Protein Type	Protease
Function	is a nuclear-encoded mitochondrial serine protease that plays critical roles in cellular protein quality control and apoptosis regulation[@ncbi].
Primary Expression	regions vulnerable to neurodegenerative processes[@strauss2005]:
Subcellular Localization	Mitochondrial intermembrane space
Molecular Weight	48 kDa
Amino Acids	458 aa
Exons	8
Pathways	Autophagy, Cholesterol, Oxidative Stress
UniProt ID	O43464
NCBI Gene ID	27429
Ensembl ID	ENSG00000103472
OMIM	606476
GeneCards	HTRA2
Human Protein Atlas	HTRA2
Associated Diseases	Infection, Inflammation, Sepsis
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, Adiponectin, ADIPOQ, AMPK, APOPTOSIS, ATG
KG Connections	264 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HTRA2 — AlphaFold O43464 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HTRA2 Gene

gene · 1289 words

→

HTRA2 Protein

protein · 2042 words

→

Pathway Diagram

graph TD
    HTRA2["HTRA2"]
    HTRA2 -->|"interacts"| Tumor["Tumor"]
    HTRA2 -->|"interacts"| Hepatitis["Hepatitis"]
    HTRA2 -->|"activates"| Als["Als"]
    HTRA2 -->|"activates"| Ms["Ms"]
    HTRA2 -->|"inhibits"| Heart_Failure["Heart Failure"]
    HTRA2 -->|"interacts"| MTOR["MTOR"]
    HTRA2 -->|"interacts"| SIRT3["SIRT3"]
    HTRA2 -->|"interacts"| PLIN2["PLIN2"]
    HTRA2 -->|"interacts"| TP53["TP53"]
    PPARA["PPARA"] -->|"interacts"| HTRA2
    ULK1["ULK1"] -->|"interacts"| HTRA2
    STX17["STX17"] -->|"interacts"| HTRA2
    SQSTM1["SQSTM1"] -->|"interacts"| HTRA2
    NOS3["NOS3"] -->|"interacts"| HTRA2
    STING1["STING1"] -->|"interacts"| HTRA2
    GLP1R["GLP1R"] -->|"interacts"| HTRA2
    SREBF1["SREBF1"] -->|"interacts"| HTRA2
    SIRT1["SIRT1"] -->|"interacts"| HTRA2
    KDM6B["KDM6B"] -->|"interacts"| HTRA2

Outgoing (155)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Als	activates	disease	0.65
Ms	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
AIM2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
CHMP7	associated_with	gene	0.60
CD8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PRKACA	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
CD4	associated_with	gene	0.60
SMAC	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
phagocytosis	activates	process	0.60
Phagocytosis	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
PHAGOCYTOSIS	activates	entity	0.60
GCLM	associated_with	gene	0.60
LC3	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mitophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
Endothelial	interacts_with	cell_type	0.60
RAS	activates	gene	0.60
RUBCNL	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
Adiponectin	interacts_with	protein	0.60
Mtor	interacts_with	pathway	0.60
complement cascade	participates_in	pathway	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60

Incoming (109)

Source	Relation	Type	Str
FOXO1	activates	entity	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
CLPP	causes	gene	0.60
CHCHD2	interacts_with	gene	0.60
FBXO7	interacts_with	gene	0.60
DMSO	activates	gene	0.60
GABA	activates	gene	0.60
GFP	activates	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTRA2 in their description or question text

No additional research found