gene

PRKACA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKACA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections

0Hypotheses

0Analyses

50Outgoing

34Incoming

Summary

PRKACA is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, implicated in. Associated with Als, Diabetes, Hypertension. Connected to 59 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PRKACA
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	40.6 kDa
Pathways	mTOR, mtor
GeneCards	PRKACA
Human Protein Atlas	PRKACA
Serine/threonine kinase	Phosphorylates serine and threonine residues
cAMP-dependent	Activity requires binding of cAMP to regulatory subunits
Heterotetrameric complex	R2C2 (2 regulatory + 2 catalytic subunits)
Substrate specificity	Broad substrate range including transcription factors, ion channels, and metabolic enzymes
Catalytic domain	Kinase domain in the C-terminal region
Nuclear localization	Can translocate to nucleus to phosphorylate transcription factors
Isoforms	Multiple catalytic subunit isoforms (Cα, Cβ, Cγ)
Autophosphorylation	Regulatory serine residues
Brain	High expression in hippocampus, cortex, cerebellum
Associated Diseases	Infection, Inflammation, Sepsis
Interactions	CAV1, AND, CPT1A, CAVEOLIN-1, Actin, Ubiquitin
KG Connections	85 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRKACA["<b>PRKACA</b>"]
    Diabetes{"Diabetes"}
    PRKACA -->|"therapeutic target"| Diabetes
    Obesity{"Obesity"}
    PRKACA -->|"therapeutic target"| Obesity
    Stroke{"Stroke"}
    PRKACA -->|"therapeutic target"| Stroke
    Als{"Als"}
    PRKACA -->|"therapeutic target"| Als
    Hypertension{"Hypertension"}
    PRKACA -->|"therapeutic target"| Hypertension
    Ischemia{"Ischemia"}
    PRKACA -->|"therapeutic target"| Ischemia
    Ms{"Ms"}
    PRKACA -->|"therapeutic target"| Ms
    AKT1["AKT1"]
    PRKACA -->|"therapeutic target"| AKT1
    TNF["TNF"]
    PRKACA -->|"therapeutic target"| TNF
    RAF1["RAF1"]
    PRKACA -->|"therapeutic target"| RAF1
    CHUK["CHUK"]
    PRKACA -->|"therapeutic target"| CHUK
    JUN["JUN"]
    PRKACA -->|"therapeutic target"| JUN
    JAK["JAK"]
    JAK -->|"therapeutic target"| PRKACA
    PI3K["PI3K"]
    PI3K -->|"therapeutic target"| PRKACA
    RELA["RELA"]
    RELA -->|"therapeutic target"| PRKACA
    PTGS2["PTGS2"]
    PTGS2 -->|"therapeutic target"| PRKACA
    style PRKACA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (51)

Target	Relation	Type	Str
Mapk	therapeutic_target	pathway	0.70
Diabetes	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Hypertension	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
AKT1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
RAF1	therapeutic_target	gene	0.60
CHUK	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
NLRC4	associated_with	gene	0.60
CD4	associated_with	gene	0.60
GCLM	associated_with	gene	0.60
MMP9	therapeutic_target	gene	0.60
MMP14	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CAV1	inhibits	gene	0.60
Jak-Stat	therapeutic_target	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
AUTOPHAGY	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Cholesterol	associated_with	pathway	0.60
Immunotherapy	associated_with	pathway	0.60
Ferroptosis	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
Pyroptosis	associated_with	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
NF-ΚB	therapeutic_target	gene	0.60
TNF-Α	therapeutic_target	gene	0.60
Lipid Metabolism	inhibits	pathway	0.60
Cholesterol	inhibits	pathway	0.60
AND	inhibits	gene	0.60
CPT1A	inhibits	gene	0.60
Actin	inhibits	protein	0.60
Ubiquitin	inhibits	protein	0.60
Ras	inhibits	protein	0.60

Incoming (35)

Source	Relation	Type	Str
PI3K	therapeutic_target	gene	0.60
RELA	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
HTRA2	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
CHMP7	associated_with	gene	0.60
CD8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MMP14	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CAV1	inhibits	gene	0.60
AKT1	therapeutic_target	gene	0.60
CHUK	therapeutic_target	gene	0.60
RAF1	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
JAK	therapeutic_target	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
TNF-Α	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
CPT1A	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-17	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
CAV1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PRKACA

Understanding Entity Pages

Summary

Wiki Pages (16)

prkaca Gene

PRKACB Protein

PRKAR1B — Protein Kinase A Regulatory Subunit 1 Beta

Caveolin-1

SUFU — Suppressor of Fused, Hedgehog Pathway Regulator

SMO — Smoothened, Frizzled Class Receptor

PRKAR1A - Protein Kinase A Regulatory Subunit 1 Alpha

RYR2 - Ryanodine Receptor 2

PDE11A - Phosphodiesterase 11A

prkaca Protein

PRKACG — Protein Kinase A Catalytic Subunit Gamma

D1 Dopamine Receptor MSNs

D2 Dopamine Receptor MSNs

PKA C-alpha Protein