Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SRXN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SRXN1 is a protein involved in neurodegeneration research. Key relationships include: biomarker for, activates, regulates. Associated with Als, Breast Cancer, Cancer. Connected to 40 entities in the SciDEX knowledge graph.
| Gene Symbol | SRXN1 |
| Function | SRXN1 (Sulfiredoxin 1) is a small antioxidant enzyme (125 amino acids) specialized in reducing overoxidized peroxiredoxins (Prxs). It catalyzes the ATP-dependent reduction of cysteine-sulfinic acid... |
| Amino Acids | 125 aa |
| Pathways | Oxidative Stress, Ferroptosis, Mtor, Oxidative Phosphorylation, Immune Response |
| GeneCards | SRXN1 |
| Human Protein Atlas | SRXN1 |
| Associated Diseases | Inflammation, Lymphoma, Tumor |
| Interactions | SLC7A11, KEAP1, OXIDATIVE STRESS, CANCER, GENES, NRF2 |
| KG Connections | 69 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SRXN1["<b>SRXN1</b>"]
Inflammation{"Inflammation"}
SRXN1 -->|"biomarker for"| Inflammation
SRXN1 -->|"associated with"| Inflammation
Lymphoma{"Lymphoma"}
SRXN1 -->|"associated with"| Lymphoma
Ms{"Ms"}
SRXN1 -->|"biomarker for"| Ms
Tumor{"Tumor"}
SRXN1 -->|"associated with"| Tumor
Oxidative_Stress(["Oxidative Stress"])
SRXN1 -->|"biomarker for"| Oxidative_Stress
SRXN1 -->|"associated with"| Oxidative_Stress
BRD4["BRD4"]
SRXN1 -->|"biomarker for"| BRD4
ATM["ATM"]
SRXN1 -->|"biomarker for"| ATM
PRDX1["PRDX1"]
SRXN1 -->|"biomarker for"| PRDX1
Ferroptosis(["Ferroptosis"])
SRXN1 -->|"associated with"| Ferroptosis
Mtor(["Mtor"])
SRXN1 -->|"biomarker for"| Mtor
NRF2["NRF2"]
NRF2 -->|"regulates"| SRXN1
NQO1["NQO1"]
NQO1 -->|"regulates"| SRXN1
GCLC["GCLC"]
GCLC -->|"regulates"| SRXN1
GCLM["GCLM"]
GCLM -->|"regulates"| SRXN1
HMOX1["HMOX1"]
HMOX1 -->|"regulates"| SRXN1
GENES["GENES"]
GENES -->|"biomarker for"| SRXN1
TXNRD1["TXNRD1"]
TXNRD1 -->|"regulates"| SRXN1
MTOR["MTOR"]
MTOR -->|"biomarker for"| SRXN1
FERROPTOSIS["FERROPTOSIS"]
FERROPTOSIS -->|"associated with"| SRXN1
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
OXIDATIVE_STRESS -->|"biomarker for"| SRXN1
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"biomarker for"| SRXN1
AND["AND"]
AND -->|"regulates"| SRXN1
style SRXN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| DLBCL | biomarker_for | disease | 0.80 |
| Inflammation | biomarker_for | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Lymphoma | associated_with | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Breast Cancer | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Oxidative Stress | biomarker_for | pathway | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| BRD4 | biomarker_for | gene | 0.60 |
| ATM | biomarker_for | gene | 0.60 |
| PRDX1 | biomarker_for | gene | 0.60 |
| Ferroptosis | associated_with | pathway | 0.60 |
| Mtor | biomarker_for | pathway | 0.60 |
| Oxidative Phosphorylation | associated_with | pathway | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| NRF2 | regulates | gene | 0.60 |
| GCLC | regulates | gene | 0.60 |
| OXIDATIVE STRESS | biomarker_for | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| GCLM | regulates | gene | 0.60 |
| FERROPTOSIS | associated_with | gene | 0.60 |
| Cell Cycle | associated_with | pathway | 0.60 |
| HMOX1 | regulates | gene | 0.60 |
| TXNRD1 | regulates | gene | 0.60 |
| INFLAMMATION | biomarker_for | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| GENES | biomarker_for | gene | 0.60 |
| NQO1 | regulates | gene | 0.60 |
| SAT1 | biomarker_for | gene | 0.60 |
| MTOR | biomarker_for | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| Fus | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| PRDX1 | associated_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NRF2 | regulates | protein | 0.82 |
| NQO1 | regulates | gene | 0.60 |
| GCLC | regulates | gene | 0.60 |
| GCLM | regulates | gene | 0.60 |
| HMOX1 | regulates | gene | 0.60 |
| GENES | biomarker_for | gene | 0.60 |
| TXNRD1 | regulates | gene | 0.60 |
| MTOR | biomarker_for | gene | 0.60 |
| FERROPTOSIS | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | biomarker_for | gene | 0.60 |
| INFLAMMATION | biomarker_for | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| KEAP1 | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ATM | biomarker_for | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| PRDX1 | biomarker_for | gene | 0.60 |
| BRD4 | biomarker_for | gene | 0.60 |
| AND | biomarker_for | gene | 0.60 |
| SAT1 | biomarker_for | gene | 0.60 |
| ACO1 | biomarker_for | gene | 0.60 |
| LPIN1 | biomarker_for | gene | 0.60 |
| MT1G | biomarker_for | gene | 0.60 |
| PEBP1 | biomarker_for | gene | 0.60 |
| mTOR | associated_with | entity | 0.50 |
| BRD4 | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||