protein

SRXN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRXN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections
0Hypotheses
0Analyses
39Outgoing
30Incoming

Summary

SRXN1 is a protein involved in neurodegeneration research. Key relationships include: biomarker for, activates, regulates. Associated with Als, Breast Cancer, Cancer. Connected to 40 entities in the SciDEX knowledge graph.

View on Wiki →

🔬 Protein Info
Gene SymbolSRXN1
FunctionSRXN1 (Sulfiredoxin 1) is a small antioxidant enzyme (125 amino acids) specialized in reducing overoxidized peroxiredoxins (Prxs). It catalyzes the ATP-dependent reduction of cysteine-sulfinic acid...
Amino Acids125 aa
PathwaysOxidative Stress, Ferroptosis, Mtor, Oxidative Phosphorylation, Immune Response
GeneCardsSRXN1
Human Protein AtlasSRXN1
Associated DiseasesInflammation, Lymphoma, Tumor
InteractionsSLC7A11, KEAP1, OXIDATIVE STRESS, CANCER, GENES, NRF2
KG Connections69 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Primed Microglia

cell · 1613 words

gclc

gene · 1305 words

GCLM — Glutamate-Cysteine Ligase Modifier Subunit

gene · 910 words

SRXN1 Protein

protein · 612 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    SRXN1["<b>SRXN1</b>"]
    Inflammation{"Inflammation"}
    SRXN1 -->|"biomarker for"| Inflammation
    SRXN1 -->|"associated with"| Inflammation
    Lymphoma{"Lymphoma"}
    SRXN1 -->|"associated with"| Lymphoma
    Ms{"Ms"}
    SRXN1 -->|"biomarker for"| Ms
    Tumor{"Tumor"}
    SRXN1 -->|"associated with"| Tumor
    Oxidative_Stress(["Oxidative Stress"])
    SRXN1 -->|"biomarker for"| Oxidative_Stress
    SRXN1 -->|"associated with"| Oxidative_Stress
    BRD4["BRD4"]
    SRXN1 -->|"biomarker for"| BRD4
    ATM["ATM"]
    SRXN1 -->|"biomarker for"| ATM
    PRDX1["PRDX1"]
    SRXN1 -->|"biomarker for"| PRDX1
    Ferroptosis(["Ferroptosis"])
    SRXN1 -->|"associated with"| Ferroptosis
    Mtor(["Mtor"])
    SRXN1 -->|"biomarker for"| Mtor
    NRF2["NRF2"]
    NRF2 -->|"regulates"| SRXN1
    NQO1["NQO1"]
    NQO1 -->|"regulates"| SRXN1
    GCLC["GCLC"]
    GCLC -->|"regulates"| SRXN1
    GCLM["GCLM"]
    GCLM -->|"regulates"| SRXN1
    HMOX1["HMOX1"]
    HMOX1 -->|"regulates"| SRXN1
    GENES["GENES"]
    GENES -->|"biomarker for"| SRXN1
    TXNRD1["TXNRD1"]
    TXNRD1 -->|"regulates"| SRXN1
    MTOR["MTOR"]
    MTOR -->|"biomarker for"| SRXN1
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"associated with"| SRXN1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"biomarker for"| SRXN1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"biomarker for"| SRXN1
    AND["AND"]
    AND -->|"regulates"| SRXN1
    style SRXN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

TargetRelationTypeStr
DLBCLbiomarker_fordisease0.80
Inflammationbiomarker_fordisease0.65
Inflammationassociated_withdisease0.65
Lymphomaassociated_withdisease0.65
Msbiomarker_fordisease0.65

Incoming (30)

SourceRelationTypeStr
NRF2regulatesprotein0.82
NQO1regulatesgene0.60
GCLCregulatesgene0.60
GCLMregulatesgene0.60
HMOX1regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found