gene

IL12A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL12A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

42Outgoing

21Incoming

Summary

IL12A encodes the p35 subunit of interleukin-12, a cytokine critical for immune cell differentiation, and plays important roles in neuroinflammation and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	IL12A
Full Name	Interleukin-12 Alpha
Chromosome	3q25.33
Protein Type	Receptor
Primary Expression	dendritic cells, macrophages, B cells, and other antigen-presenting cells[@gately1998]
Amino Acids	253 aa
Exons	7
Pathways	NF-κB
GeneCards	IL12A
Human Protein Atlas	IL12A
Cytokine	Interaction
IFN-γ	Synergistic
IL-1β	Additive
TNF-α	Synergistic
IL-10	Antagonistic
Associated Diseases	Aging, Alzheimer, Inflammation, Ms, Neurodegeneration, Parkinson
Interactions	IL1B, TNFA, FYN, STAT3, Stat3, MICROGLIA ACTIVATION
KG Connections	63 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL12A["<b>IL12A</b>"]
    cognitive_aging["cognitive_aging"]
    IL12A -->|"associated with"| cognitive_aging
    neurodegeneration["neurodegeneration"]
    IL12A -->|"implicated in"| neurodegeneration
    FYN["FYN"]
    FYN -->|"upregulates"| IL12A
    STAT3["STAT3"]
    STAT3 -->|"regulates"| IL12A
    AR["AR"]
    AR -->|"inhibits"| IL12A
    sorafenib["sorafenib"]
    sorafenib -->|"upregulates"| IL12A
    style IL12A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

Target	Relation	Type	Str
cognitive_aging	associated_with	phenotype	0.70
Parkinson	causes	disease	0.65
Aging	causes	disease	0.65
Inflammation	causes	disease	0.65
Alzheimer	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Ms	causes	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
FYN	causes	gene	0.60
IL1B	activates	gene	0.60
STAT3	causes	gene	0.60
TNFA	activates	gene	0.60
FYN	activates	gene	0.60
STAT3	activates	gene	0.60
Stat3	activates	protein	0.60
ALZHEIMER	causes	gene	0.60
PARKINSON	causes	gene	0.60
NF-ΚB	causes	gene	0.60
INFLAMMATION	causes	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
NEURON	causes	gene	0.60
MICROGLIA	activates	gene	0.60
Nf-Κb	causes	pathway	0.60
AND	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
PARKINSON	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
Dopaminergic	activates	cell_type	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
Microglia Activation	activates	pathway	0.60
Cytokine	activates	protein	0.60
Raf	activates	protein	0.60
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
DOPAMINERGIC	activates	concept	0.50
CYTOKINE	activates	concept	0.50

Incoming (21)

Source	Relation	Type	Str
FYN	upregulates	gene	0.80
STAT3	regulates	gene	0.80
AR	inhibits	gene	0.80
sorafenib	upregulates	drug	0.70
TNFA	activates	gene	0.60
STAT3	causes	gene	0.60
IL1B	activates	gene	0.60
FYN	causes	gene	0.60
FYN	activates	gene	0.60
STAT3	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
NF-ΚB	causes	gene	0.60
ALZHEIMER	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
INFLAMMATION	causes	gene	0.60
PARKINSON	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
PARKINSON	activates	gene	0.60
microglia	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL12A

Understanding Entity Pages

Summary

Wiki Pages (7)

IL12A — Interleukin-12 Alpha

IL-12 Protein

ar

IL35 — Interleukin 35

FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase