concept

ITGB8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITGB8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

42Outgoing

31Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ITGB8
Key Genes/Proteins	TGFB1, IL1B, TNFA, USH2A, APOE, EPHB4
Related Diseases	Papillary Renal Cell Carcinoma, Als, Neurodegeneration, Alzheimer, ALS
Related Pathways	Tgf-Beta Signaling, TGFB signaling

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ITGB8["ITGB8"]
    ITGB8 -->|"downregulates"| Papillary_Renal_Cell_Carcinoma["Papillary Renal Cell Carcinoma"]
    ITGB8 -->|"activates"| Als["Als"]
    ITGB8 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ITGB8 -->|"activates"| Alzheimer["Alzheimer"]
    ITGB8 -->|"activates"| ALS["ALS"]
    ITGB8 -->|"activates"| TGFB1["TGFB1"]
    ITGB8 -->|"regulates"| TGFB_signaling["TGFB signaling"]
    ITGB8 -->|"causes"| Microglia["Microglia"]
    MICROGLIA["MICROGLIA"] -->|"causes"| ITGB8
    SMAD2["SMAD2"] -->|"activates"| ITGB8
    SMAD3["SMAD3"] -->|"activates"| ITGB8
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| ITGB8
    GENES["GENES"] -->|"activates"| ITGB8
    ASTROCYTE["ASTROCYTE"] -->|"activates"| ITGB8
    APOE4["APOE4"] -->|"activates"| ITGB8
    APOE["APOE"] -->|"activates"| ITGB8

Outgoing (42)

Target	Relation	Type	Str
Tgf-Beta Signaling	activates	pathway	0.90
extracellular vesicles	targets	compound	0.90
Papillary Renal Cell Carcinoma	downregulates	disease	0.70
microglia	expressed_in	cell_type	0.70
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
TGFB1	activates	protein	0.60
TGFB signaling	regulates	pathway	0.60
IL1B	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
USH2A	associated_with	gene	0.60
APOE	associated_with	gene	0.60
EPHB4	associated_with	gene	0.60
IL6	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
TGFB	associated_with	gene	0.60
ANGPTL4	associated_with	gene	0.60
Microglia	causes	cell_type	0.60
APOE3	activates	gene	0.60
AND	inhibits	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
INPP5D	activates	gene	0.60
AMYLOID	activates	gene	0.60
MICROGLIA	activates	gene	0.60
TAU	activates	gene	0.60
Amyloid	activates	pathway	0.60
AND	associated_with	gene	0.60
SMAD2	activates	gene	0.60
AND	causes	gene	0.60
MICROGLIA	causes	gene	0.60
Radial Glia	expressed_in	cell_type	0.60
SMAD3	activates	gene	0.60
Ras	activates	protein	0.60
TNFA	interacts_with	gene	0.60
USH2A	interacts_with	gene	0.60
JAG1	targets	gene	0.60
TGFB2	targets	gene	0.60
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55

Incoming (31)

Source	Relation	Type	Str
MICROGLIA	causes	gene	0.60
SMAD2	activates	gene	0.60
SMAD3	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
APOE4	activates	gene	0.60
APOE	activates	gene	0.60
LGALS3	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APP	activates	gene	0.60
IL6	associated_with	gene	0.60
GENES	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BRAIN INJURY	activates	gene	0.60
EPHB4	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
USH2A	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
TGFB	associated_with	gene	0.60
ANGPTL4	associated_with	gene	0.60
APOE4	inhibits	gene	0.60
ADAM17	interacts_with	gene	0.60
ANGPTL4	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
EPHB4	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
GRIN3A	expressed_in	gene	0.60
ICAM1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ITGB8

Understanding Entity Pages

Wiki Pages (4)

USH2A Protein

INPP5D — Inositol Polyphosphate-5-Phosphatase D (SHIP1)