gene

JNK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JNK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections
0Hypotheses
0Analyses
32Outgoing
20Incoming
0Experiments

Summary

JNK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with ALS, Als. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolJNK2
Full NameMitogen-Activated Protein Kinase 9
AliasesMAPK9
Chromosome5q35.3
Protein FamilyMAPK family (JKN/SAPK)
Molecular Weight46 kDa
Amino Acids424 aa
PathwaysMAPK, Mapk
UniProt ID[P53779](https://www.uniprot.org/uniprot/P53779)
Ensembl IDENSG00000050748
GeneCardsJNK2
Human Protein AtlasJNK2
JNK1 (MAPK8)Ubiquitously expressed, ~46 kDa
JNK2 (MAPK9)Ubiquitously expressed, ~46 kDa
JNK3 (MAPK10)Neuron-specific, ~46 kDa
Associated DiseasesALS, Ms
InteractionsJUN, JNK1, BIP, P38, Jnk, C-JUN
KG Connections52 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

JNK2 (MAPK9)

gene · 869 words

MAPK9 Gene

gene · 3305 words

MAPK/ERK Signaling Pathway in Neurodegeneration

mechanism · 3210 words

jnk-p38-mapk-parkinsons

mechanism · 3111 words

JNK/p38 MAPK Signaling Pathway in Neurodegeneration

mechanism · 2736 words

MAP2K7

gene · 2045 words

Pathway Diagram

graph TD
    JNK2["<b>JNK2</b>"]
    Als{"Als"}
    JNK2 -->|"activates"| Als
    ALS{"ALS"}
    JNK2 -->|"activates"| ALS
    Er_Stress(["Er Stress"])
    JNK2 -->|"activates"| Er_Stress
    JUN["JUN"]
    JNK2 -->|"activates"| JUN
    JNK1["JNK1"]
    JNK2 -->|"activates"| JNK1
    C_JUN["C-JUN"]
    JNK2 -->|"activates"| C_JUN
    BIP["BIP"]
    JNK2 -->|"activates"| BIP
    P38["P38"]
    JNK2 -->|"activates"| P38
    Chaperone(["Chaperone"])
    JNK2 -->|"activates"| Chaperone
    neurodegeneration["neurodegeneration"]
    JNK2 -->|"implicated in"| neurodegeneration
    JUN -->|"activates"| JNK2
    BIP -->|"activates"| JNK2
    JNK1 -->|"activates"| JNK2
    P38 -->|"activates"| JNK2
    C_JUN -->|"activates"| JNK2
    AND["AND"]
    AND -->|"activates"| JNK2
    style JNK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

TargetRelationTypeStr
Alsactivatesdisease0.65
ALSactivatesdisease0.65
Neuroinflammationtherapeutic_targetdisease0.65
Neurodegenerationtherapeutic_targetdisease0.65
Alzheimertherapeutic_targetdisease0.65

Incoming (20)

SourceRelationTypeStr
JUNactivatesgene0.60
BIPactivatesgene0.60
JNK1activatesgene0.60
P38activatesgene0.60
JNKexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found