Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about JNK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
JNK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with ALS, Als. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | JNK2 |
| Full Name | Mitogen-Activated Protein Kinase 9 |
| Aliases | MAPK9 |
| Chromosome | 5q35.3 |
| Protein Family | MAPK family (JKN/SAPK) |
| Molecular Weight | 46 kDa |
| Amino Acids | 424 aa |
| Pathways | MAPK, Mapk |
| UniProt ID | [P53779](https://www.uniprot.org/uniprot/P53779) |
| Ensembl ID | ENSG00000050748 |
| GeneCards | JNK2 |
| Human Protein Atlas | JNK2 |
| JNK1 (MAPK8) | Ubiquitously expressed, ~46 kDa |
| JNK2 (MAPK9) | Ubiquitously expressed, ~46 kDa |
| JNK3 (MAPK10) | Neuron-specific, ~46 kDa |
| Associated Diseases | ALS, Ms |
| Interactions | JUN, JNK1, BIP, P38, Jnk, C-JUN |
| KG Connections | 52 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
JNK2["<b>JNK2</b>"]
Als{"Als"}
JNK2 -->|"activates"| Als
ALS{"ALS"}
JNK2 -->|"activates"| ALS
Er_Stress(["Er Stress"])
JNK2 -->|"activates"| Er_Stress
JUN["JUN"]
JNK2 -->|"activates"| JUN
JNK1["JNK1"]
JNK2 -->|"activates"| JNK1
C_JUN["C-JUN"]
JNK2 -->|"activates"| C_JUN
BIP["BIP"]
JNK2 -->|"activates"| BIP
P38["P38"]
JNK2 -->|"activates"| P38
Chaperone(["Chaperone"])
JNK2 -->|"activates"| Chaperone
neurodegeneration["neurodegeneration"]
JNK2 -->|"implicated in"| neurodegeneration
JUN -->|"activates"| JNK2
BIP -->|"activates"| JNK2
JNK1 -->|"activates"| JNK2
P38 -->|"activates"| JNK2
C_JUN -->|"activates"| JNK2
AND["AND"]
AND -->|"activates"| JNK2
style JNK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Fibrosis | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| JUN | activates | gene | 0.60 |
| JNK1 | activates | gene | 0.60 |
| BIP | activates | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| Jnk | activates | protein | 0.60 |
| ER stress | activates | process | 0.60 |
| Er Stress | activates | pathway | 0.60 |
| C-JUN | activates | gene | 0.60 |
| Chaperone | activates | pathway | 0.60 |
| NEURODEGENERATION | therapeutic_target | gene | 0.60 |
| C-JUN | therapeutic_target | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| Proteasome | therapeutic_target | pathway | 0.60 |
| Mapk | therapeutic_target | pathway | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Ubiquitin-Proteasome | therapeutic_target | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| MAP | activates | gene | 0.60 |
| MAP | co_expressed_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| JUN | activates | gene | 0.60 |
| BIP | activates | gene | 0.60 |
| JNK1 | activates | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| JNK | expressed_in | gene | 0.60 |
| JNK3 | expressed_in | gene | 0.60 |
| JNK1 | expressed_in | gene | 0.60 |
| JUN | therapeutic_target | gene | 0.60 |
| UBIQUITIN | therapeutic_target | gene | 0.60 |
| C-JUN | activates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | therapeutic_target | gene | 0.60 |
| ATP | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 0.60 |
| JNK1 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||