protein

MAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

93Connections

2Hypotheses

3Analyses

50Outgoing

38Incoming

Summary

DUSP6 (also known as MKP3) is a dual-specificity phosphatase that specifically dephosphorylates and inactivates ERK1/2. It functions as a negative regulator of MAPK signaling and has been implicated in neurodegenerative diseases including Parkinson's disease.

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🔬 Protein Info

Gene Symbol	MAP
Aliases	also known as MKP3
Molecular Weight	39.8 kDa
Pathways	pathway: [@dusp6_erk2019], MAPK pathway, MAPK, MAPK Signaling
GeneCards	MAP
Human Protein Atlas	MAP
Data mesh	Securely combines siloed datasets across institutions
No-code analytics	Self-service apps with built-in statistical and ML algorithms
Smart APIs	Programmatic access to harmonized datasets
Multi-modal support	Clinical, genomic, and multi-omic data integration
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Parkinson, neurodegeneration, neuroinflammation
Interactions	VGLUT1, TNF, P38, MLKL, CD33, P2RY12
KG Connections	93 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Novel Therapy Index

idea · 10647 words

→

Pathway Diagram

graph TD
    MAP["<b>MAP</b>"]
    CD33(["CD33"])
    MAP -->|"activates"| CD33
    P2RY1(["P2RY1"])
    MAP -->|"co_discussed"| P2RY1
    P2RY12(["P2RY12"])
    MAP -->|"activates"| P2RY12
    CD44(["CD44"])
    MAP -->|"activates"| CD44
    NEURON(["NEURON"])
    MAP -->|"co_discussed"| NEURON
    WAS(["WAS"])
    MAP -->|"co_discussed"| WAS
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"interacts_with"| MAP
    GENES(["GENES"])
    GENES -->|"co_discussed"| MAP
    HCRTR1(["HCRTR1"])
    HCRTR1 -->|"co_discussed"| MAP
    HCRTR2(["HCRTR2"])
    HCRTR2 -->|"interacts_with"| MAP
    style MAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (55)

Target	Relation	Type	Str
MAPK signaling	participates_in	pathway	0.80
neuroinflammation	activates	disease	0.80
ALS	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
PGAM5	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PS1	associated_with	gene	0.60
Alzheimer's disease	inhibits	disease	0.60
VGLUT1	inhibits	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TNF	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
Alzheimer's disease	causes	disease	0.60
P38	activates	gene	0.60
TNF	targets	gene	0.60
PTEN	regulates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
MAPK	expressed_in	gene	0.60
MAPK7	expressed_in	gene	0.60
MRPS31	expressed_in	gene	0.60
RIPK2	expressed_in	gene	0.60
UHRF1	expressed_in	gene	0.60
necroptosis	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
oligodendrocytes	expressed_in	cell_type	0.60
neurodegeneration	activates	disease	0.60
synaptic plasticity	participates_in	pathway	0.60
ROS	regulates	gene	0.60
MLKL	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
neuroinflammation	causes	disease	0.60
Wnt signaling	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
MAP2	regulates	gene	0.55
insulin signaling	participates_in	pathway	0.55
neurons	expressed_in	cell_type	0.55
MAP6	associated_with	gene	0.55
astrocytes	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55
CD33	activates	gene	0.50
P2RY1	co_discussed	gene	0.50
P2RY12	activates	gene	0.50
CD44	activates	gene	0.50
NEURON	co_discussed	gene	0.50
WAS	co_discussed	protein	0.50
DYSTROPHIN	inhibits	protein	0.50
STING	co_discussed	gene	0.50

Incoming (38)

Source	Relation	Type	Str
AKT	associated_with	gene	0.60
ERK	associated_with	gene	0.60
APP	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
BDNF	inhibits	gene	0.60
ATM	regulates	gene	0.60
ABCA7	expressed_in	gene	0.60
ARF1	expressed_in	gene	0.60
ATG7	expressed_in	gene	0.60
E2F2	expressed_in	gene	0.60
ELAVL1	expressed_in	gene	0.60
G6PD	expressed_in	gene	0.60
GRID2	expressed_in	gene	0.60
HCRTR1	interacts_with	gene	0.60
HCRTR1	biomarker_for	gene	0.60
HCRTR2	biomarker_for	gene	0.60
JNK1	activates	gene	0.60
JNK2	activates	gene	0.60
DNA	regulates	gene	0.60
CX3CL1	activates	gene	0.60
CX3CR1	activates	gene	0.60
LOX	associated_with	gene	0.60
MAO	associated_with	gene	0.60
CDK5	activates	gene	0.60
ERK1	activates	gene	0.60
GSK3	activates	gene	0.60
ALZHEIMER	interacts_with	gene	0.50
GENES	co_discussed	gene	0.50
HCRTR1	co_discussed	gene	0.50
HCRTR2	interacts_with	gene	0.50
JNK1	co_expressed_with	gene	0.50
JNK2	co_expressed_with	gene	0.50
BCL2	co_expressed_with	gene	0.50
BNIP3	co_expressed_with	gene	0.50
CBL	co_expressed_with	gene	0.50
ERK	co_expressed_with	protein	0.50
HCRTR1	co_expressed_with	gene	0.50
HCRTR2	co_expressed_with	gene	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici	0.609	neurodegeneration	Should microtubule-stabilizing drugs be
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme	0.480	neurodegeneration	Selective vulnerability of entorhinal co

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Tau and MAP6 establish labile and stable domains on microtubules. [PMID:40040809]	Kirimtay K, Huang W, Sun X, Qiang L, Wan	iScience	2025	1
Antagonistic roles of tau and MAP6 in regulating neuronal development. [PMID:39257379]	Sun X, Yu W, Baas PW, Toyooka K, Qiang L	J Cell Sci	2024	1
Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Storie [PMID:34025352]	Cuveillier C, Boulan B, Ravanello C, Den	Front Mol Neurosci	2021	1
Tau: It's Not What You Think. [PMID:30929793]	Baas PW, Qiang L	Trends Cell Biol	2019	1
Stability properties of neuronal microtubules. [PMID:26887570]	Baas PW, Rao AN, Matamoros AJ, Leo L	Cytoskeleton (Hoboken)	2016	1
Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system att [PMID:41707770]	Yang Q, Xu Y, Zhan Y, Li J, Peng R, Yu B	Journal of controlled release	2026	0
The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. [PMID:41825505]	Jia Y, Lei J, Jiang Y, Xue L, Chen T, Wa	Neuropharmacology	2026	0
BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associ [PMID:40910579]	Atwa A, Alhadidy MM, Lamp J, Combs B, Ka	Journal of proteome research	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
ReMAPping the microtubule landscape: How phosphorylation dictates the activities [PMID:28980356]	Ramkumar A, Jong BY, Ori-McKenney KM	Developmental dynamics : an of	2018	0
Inferring patterns of folktale diffusion using genomic data. [PMID:28784786]	["Bortolini E", "Pagani L", "Crema E", "	Proceedings of the National Ac	2017	0
Purification and Characterization of Progenitor and Mature Human Astrocytes Reve [PMID:26687838]	["Zhang Y", "Sloan S", "Clarke L", "Cane	Neuron	2016	0
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severin [PMID:24065130]	["Zempel H", "Luedtke J", "Kumar Y", "Bi	The EMBO journal	2013	0
Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). [PMID:21902667]	Gozes I	Current pharmaceutical design	2011	0
Decreased neuroautonomic complexity in men during an acute major depressive epis [PMID:22832529]	["Leistedt S", "Linkowski P", "Lanquart	Translational psychiatry	2011	0
Bidirectional activity-dependent plasticity at corticostriatal synapses. [PMID:16339023]	["Fino E", "Glowinski J", "Venance L"]	The Journal of neuroscience :	2005	0
STOP proteins. [PMID:14567673]	Bosc C, Andrieux A, Job D	Biochemistry	2003	0
Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hy [PMID:12070343]	["Zhao R", "Masayasu H", "Holmgren A"]	Proceedings of the National Ac	2002	0
STOP proteins. [PMID:15218867]	Bosc C, Oenarier E, Andrieux A, Job D	Cell structure and function	1999	0

MAP

Understanding Entity Pages

Summary

Wiki Pages (21)

Tag.bio (Healthcare Data Mesh)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Pathway Diagram

Outgoing (55)

Incoming (38)

Targeting Hypotheses (2)

Mentioning Analyses (3)

How do protein-protein interactions determine subcellular localization and funct

What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurolog

Astrocyte reactivity subtypes in neurodegeneration

Related Papers (19)

MAP

Understanding Entity Pages

Summary

Wiki Pages (21)

Tag.bio (Healthcare Data Mesh)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

NPM1 Gene

PI-2620 Tau PET in PSP

Neurons — Cell Type Hierarchy

GRIA3 Gene

Multiple System Atrophy

Frontotemporal Dementia (FTD)

PD Cure Roadmap

Pathway Diagram

Outgoing (55)

Incoming (38)

Targeting Hypotheses (2)

Mentioning Analyses (3)

How do protein-protein interactions determine subcellular localization and funct

What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurolog

Astrocyte reactivity subtypes in neurodegeneration

Related Papers (19)