concept

INTERNEURON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERNEURON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

447Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

4Experiments

0Debates

Summary

INTERNEURON is a concept in neurodegeneration research. Key relationships include: associated with, co discussed, targets. Associated with ALS. Connected to 43 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	INTERNEURON
Key Genes/Proteins	AKT, ALZHEIMER, AMYLOID, APP
Related Diseases	acetylcholine, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AUTISM

Pathway Diagram

graph TD
    INTERNEURON["INTERNEURON"]
    INTERNEURON -->|"expressed in"| INTERNEURONS["INTERNEURONS"]
    INTERNEURON -->|"expressed in"| NEURON["NEURON"]
    INTERNEURON -->|"expressed in"| NEURONS["NEURONS"]
    CORTEX["CORTEX"] -->|"regulates"| INTERNEURON
    COMPLEMENT["COMPLEMENT"] -->|"inhibits"| INTERNEURON
    AMYLOID["AMYLOID"] -->|"targets"| INTERNEURON
    APP["APP"] -->|"targets"| INTERNEURON
    GABAERGIC["GABAERGIC"] -->|"targets"| INTERNEURON
    MEF2C["MEF2C"] -->|"expressed in"| INTERNEURON
    MTOR["MTOR"] -->|"expressed in"| INTERNEURON
    FUS["FUS"] -->|"expressed in"| INTERNEURON
    LYSOSOME["LYSOSOME"] -->|"expressed in"| INTERNEURON
    RAB5["RAB5"] -->|"expressed in"| INTERNEURON

Outgoing (96)

Target	Relation	Type	Str
NEURONS	interacts_with	cell_type	0.65
NEURONS	associated_with	cell_type	0.65
INTERNEURONS	associated_with	cell_type	0.65
NEURON	associated_with	cell_type	0.65
MICROGLIA	contributes_to	cell_type	0.65
OLIGODENDROCYTE	contributes_to	cell_type	0.65
THALAMUS	promotes	brain_region	0.60
PYRAMIDAL	expressed_in	cell_type	0.60
NEURON	interacts_with	cell_type	0.60
PYRAMIDAL	regulates	cell_type	0.60
NEURON	inhibits	cell_type	0.60
INTERNEURONS	targets	cell_type	0.60
NEURON	targets	cell_type	0.60
NEURONS	targets	cell_type	0.60
INTERNEURONS	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
INTERNEURONS	expressed_in	cell_type	0.60
NEURON	expressed_in	cell_type	0.60
NEURONS	expressed_in	cell_type	0.60
INTERNEURONS	causes	cell_type	0.60
NEURON	causes	cell_type	0.60
NEURONS	causes	cell_type	0.60
INTERNEURONS	protects_against	cell_type	0.60
NEURON	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
INTERNEURONS	regulates	cell_type	0.60
NEURON	regulates	cell_type	0.60
NEURONS	regulates	cell_type	0.60
PREFRONTAL	activates	brain_region	0.60
PREFRONTAL	inhibits	brain_region	0.60
SCHIZOPHRENIA	regulates	disease	0.60
NEURODEGENERATION	biomarker_for	disease	0.60
NEURON	biomarker_for	cell_type	0.60
NEURONS	biomarker_for	cell_type	0.60
SCHIZOPHRENIA	associated_with	disease	0.60
PYRAMIDAL	causes	cell_type	0.60
T CELL	contributes_to	cell_type	0.60
SYN1	expressed_in	gene	0.60
Hippocampus	expressed_in	brain_region	0.50
INTERNEURONS	inhibits	concept	0.50
Synaptic Transmission	activates	pathway	0.50
PREFRONTAL CORTEX	activates	concept	0.50
PREFRONTAL CORTEX	inhibits	concept	0.50
AMYLOID-β	inhibits	concept	0.50
THALAMUS	activates	concept	0.50
NUCLEUS	interacts_with	concept	0.50
EXTRACELLULAR MATRIX	interacts_with	concept	0.50
Cortex	expressed_in	brain_region	0.50
ISCHEMIA	co_discussed	entity	0.50

Incoming (351)

Source	Relation	Type	Str
CORTEX	targets	brain_region	0.65
GABAERGIC	inhibits	cell_type	0.65
AUTISM	expressed_in	disease	0.65
GABAERGIC	biomarker_for	cell_type	0.65
CHOLINERGIC	contributes_to	cell_type	0.60
CHOLINERGIC	expressed_in	cell_type	0.60
C-FOS	activates	gene	0.60
CX3CR1	activates	gene	0.60
FOSB	activates	gene	0.60
PKC	activates	gene	0.60
TLR4	activates	gene	0.60
SST	encodes	gene	0.60
RNA	encodes	gene	0.60
PVALB	encodes	gene	0.60
EPILEPSY	encodes	gene	0.60
SST	expressed_in	gene	0.60
INS	associated_with	gene	0.60
SST	associated_with	gene	0.60
GAIN	regulates	gene	0.60
SST	regulates	gene	0.60
AUTISM	associated_with	disease	0.60
EPILEPSY	therapeutic_target	gene	0.60
PVALB	therapeutic_target	gene	0.60
SST	therapeutic_target	gene	0.60
SYNAPSE	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PARKINSON	regulates	gene	0.60
GABAERGIC	targets	cell_type	0.60
CORTEX	activates	brain_region	0.60
GABAERGIC	activates	cell_type	0.60
APP	targets	gene	0.60
DEPRESSION	expressed_in	gene	0.60
CHRNA7	regulates	gene	0.60
GAD1	associated_with	gene	0.60
AXON	contributes_to	gene	0.60
HTT	expressed_in	gene	0.60
HUNTINGTON	expressed_in	gene	0.60
BDNF	mediates	gene	0.60
DENTATE GYRUS	regulates	brain_region	0.60
CA3	regulates	brain_region	0.60
CA1	regulates	brain_region	0.60
GDNF	regulates	gene	0.60
RNA	regulates	gene	0.60
TAU	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
SST	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
TAU	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
SST	activates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.968	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.959	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.955	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	alzheimers	Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron-	0.884	alzheimers	Circuit-level neural dynamics in neurode

Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.869	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.865	alzheimers	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.865	alzheimers	Circuit-level neural dynamics in neurode
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.865	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.827	alzheimers	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.811	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	alzheimers	Circuit-level neural dynamics in neurode
Gamma entrainment reactivates PV+ interneuron ensembles to r	0.777	alzheimers	Gamma entrainment therapy to restore hip
Prefrontal sensory gating circuit restoration via PV interne	0.775	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.767	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.754	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.752	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.748	alzheimers	Circuit-level neural dynamics in neurode
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.743	neurodegeneration	What are the physiological functions of
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.683	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.659	neurodegeneration	What molecular mechanisms underlie the d
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.656	neurodegeneration	What is the molecular mechanism by which
Closed-loop optogenetic targeting of PV interneurons to rest	0.633	als	-
Closed-loop transcranial focused ultrasound targeting motor	0.633	als	-
Closed-loop transcranial focused ultrasound to restore hippo	0.000	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with gamma entra	0.000	alzheimers	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	human patients	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	mouse models of Alzheimer's di	proposed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	cultured cells under arsenite	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	human brain tissue	proposed	N/A

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Targeting Neural Oscillations for Cognitive Enhancement in Alzheimer’s Disease [PMID:40142358]	Federica Palacino, P. Manganotti, A. Ben	{'name': 'Medicina', 'volume':	2025
Roles of NAD+ in Health and Aging. [PMID:37848251]	Lautrup S, Hou Y, Fang EF, Bohr VA	Cold Spring Harbor perspective	2024
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
The different autophagy degradation pathways and neurodegeneration. [PMID:35134347]	Fleming A, Bourdenx M, Fujimaki M, Karab	Neuron	2022
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Bur [PMID:34958021]	M. Dhaynaut, G. Sprugnoli, D. Cappon	{'name': "Journal of Alzheimer	2021
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive defi [PMID:30742114]	Unknown	Nature neuroscience	2019
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERNEURON in their description or question text

INTERNEURON

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (96)

Incoming (351)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (4)

Related Papers (12)

Debates (0)

Related Research

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and bl

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Gamma entrainment reactivates PV+ interneuron ensembles to restore inhibition/ex

Prefrontal sensory gating circuit restoration via PV interneuron enhancement

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-ga

Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r