concept

INTERNEURON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERNEURON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

423Connections

30Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

INTERNEURON is a concept in neurodegeneration research. Key relationships include: associated with, co discussed, targets. Associated with ALS. Connected to 43 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	INTERNEURON
Related Diseases	AUTISM
Linked Hypotheses	34 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Pathway Diagram

graph TD
    INTERNEURON["<b>INTERNEURON</b>"]
    INTERNEURON -->|"expressed in"| INTERNEURONS["INTERNEURONS"]
    INTERNEURON -->|"expressed in"| NEURON["NEURON"]
    INTERNEURON -->|"expressed in"| NEURONS["NEURONS"]
    CORTEX["CORTEX"] -->|"regulates"| INTERNEURON
    COMPLEMENT["COMPLEMENT"] -->|"inhibits"| INTERNEURON
    AMYLOID["AMYLOID"] -->|"targets"| INTERNEURON
    APP["APP"] -->|"targets"| INTERNEURON
    GABAERGIC["GABAERGIC"] -->|"targets"| INTERNEURON
    MEF2C["MEF2C"] -->|"expressed in"| INTERNEURON
    MTOR["MTOR"] -->|"expressed in"| INTERNEURON
    FUS["FUS"] -->|"expressed in"| INTERNEURON
    LYSOSOME["LYSOSOME"] -->|"expressed in"| INTERNEURON
    RAB5["RAB5"] -->|"expressed in"| INTERNEURON

Outgoing (86)

Target	Relation	Type	Str
INTERNEURONS	promotes	cell_type	0.65
NEURON	promotes	cell_type	0.65
NEURONS	promotes	cell_type	0.65
INTERNEURONS	reduces	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
NEURONS	interacts_with	cell_type	0.65
MICROGLIA	contributes_to	cell_type	0.65
OLIGODENDROCYTE	contributes_to	cell_type	0.65
INTERNEURONS	expressed_in	cell_type	0.60
NEURON	expressed_in	cell_type	0.60
NEURONS	expressed_in	cell_type	0.60
INTERNEURONS	causes	cell_type	0.60
NEURON	causes	cell_type	0.60
NEURONS	causes	cell_type	0.60
INTERNEURONS	protects_against	cell_type	0.60
NEURON	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
INTERNEURONS	regulates	cell_type	0.60
NEURON	regulates	cell_type	0.60
NEURONS	regulates	cell_type	0.60
NEURON	associated_with	cell_type	0.60
INTERNEURONS	targets	cell_type	0.60
NEURON	targets	cell_type	0.60
NEURONS	targets	cell_type	0.60
INTERNEURONS	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
PREFRONTAL	activates	brain_region	0.60
PREFRONTAL	inhibits	brain_region	0.60
INTERNEURONS	contributes_to	cell_type	0.60
NEURON	contributes_to	cell_type	0.60
NEURONS	contributes_to	cell_type	0.60
SCHIZOPHRENIA	regulates	disease	0.60
INTERNEURONS	impairs	cell_type	0.60
NEURON	impairs	cell_type	0.60
NEURONS	impairs	cell_type	0.60
NEURODEGENERATION	biomarker_for	disease	0.60
NEURON	biomarker_for	cell_type	0.60
NEURONS	biomarker_for	cell_type	0.60
NEURONS	associated_with	cell_type	0.60
SCHIZOPHRENIA	associated_with	disease	0.60
SCHIZOPHRENIA	impairs	disease	0.60
PYRAMIDAL	causes	cell_type	0.60
PYRAMIDAL	expressed_in	cell_type	0.60
NEURON	inhibits	cell_type	0.60
THALAMUS	promotes	brain_region	0.60
PYRAMIDAL	regulates	cell_type	0.60
NEURON	interacts_with	cell_type	0.60
T CELL	contributes_to	cell_type	0.60

Incoming (337)

Source	Relation	Type	Str
CORTEX	targets	brain_region	0.65
GABAERGIC	inhibits	cell_type	0.65
GABAERGIC	biomarker_for	cell_type	0.65
AUTISM	expressed_in	disease	0.65
CORTEX	regulates	brain_region	0.60
APP	targets	gene	0.60
GABAERGIC	targets	cell_type	0.60
CORTEX	activates	brain_region	0.60
GABAERGIC	activates	cell_type	0.60
FRONTAL	activates	brain_region	0.60
FRONTAL	inhibits	brain_region	0.60
CORTEX	contributes_to	brain_region	0.60
CORTEX	biomarker_for	brain_region	0.60
GABAERGIC	expressed_in	cell_type	0.60
CA1	regulates	brain_region	0.60
CA3	regulates	brain_region	0.60
DENTATE GYRUS	regulates	brain_region	0.60
AUTISM	contributes_to	disease	0.60
BDNF	mediates	gene	0.60
GABAERGIC	associated_with	cell_type	0.60
ASTROCYTE	contributes_to	cell_type	0.60
ASTROCYTES	contributes_to	cell_type	0.60
GABAERGIC	contributes_to	cell_type	0.60
CHOLINERGIC	expressed_in	cell_type	0.60
CHOLINERGIC	contributes_to	cell_type	0.60
ALZHEIMER'S DISEASE	associated_with	disease	0.56
CORTEX	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
APP	co_discussed	entity	0.50
GABA	co_discussed	entity	0.50
GABAergic	co_discussed	entity	0.50
RAB5	inhibits	protein	0.50
RAB11	inhibits	gene	0.50
C1Q/C3	inhibits	concept	0.50
Stem Cell	associated_with	cell_type	0.50
NEURONS	associated_with	concept	0.50
GAIN	inhibits	gene	0.50
NEURONS	inhibits	concept	0.50
Cortex	activates	brain_region	0.50
NEURONS	activates	concept	0.50
Cortex	inhibits	brain_region	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
Neurodegeneration	regulates	disease	0.50
PVALB	regulates	gene	0.50
inflammation	regulates	pathway	0.50
Cortex	regulates	brain_region	0.50
SCHIZOPHRENIA	interacts_with	disease	0.50
PVALB	interacts_with	gene	0.50
SCHIZOPHRENIA	associated_with	disease	0.50
PVALB	associated_with	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode

Beta-frequency entrainment therapy targeting PV interneuron-	0.669	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.660	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to	0.639	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Prefrontal sensory gating circuit restoration via PV interne	0.587	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.576	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.569	neurodegeneration	What is the molecular mechanism by which
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.568	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode
Complement C1q Suppression as Mechanism Linking Exercise Pla	0.560	neurodegeneration	What are the specific circulating factor
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.527	neurodegeneration	What are the physiological functions of
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.497	neurodegeneration	Are interneuron oscillation deficits com
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.473	neurodegeneration	What molecular mechanisms underlie the d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361]	Han SC, Han J, Min YK, Han JW, Jeong HJ	Am J Sports Med	2026
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967]	Huang X, Francis I, Gu Y, Saha SC	Respir Physiol Neurobiol	2026
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313]	Samante FI, Galangue CG, Avelino DC, Bel	Pharmacol Rep	2026
Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213]	Wu J, Lin B, Yang S, Xu S, Li S	J Prosthet Dent	2026
Fate plasticity of interneuron specification. [PMID:40264797]	Mostajo-Radji MA, Leon WRM, Breevoort A,	iScience	2025
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610]	Gelot AB, Draia-Nicolau TO, Mathieu R, S	Epilepsia	2025
Brain connectivity and transcriptional changes induced by rTMS in first-episode [PMID:40274783]	Guan M, Xie Y, Wang Z, Miao Y, Li X et a	Transl Psychiatry	2025
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068]	Zhang C, Xie Z, Wang N	Am J Transl Res	2025
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024
Cortical assembloids support the development of fast-spiking human PVALB+ cortic [PMID:39651135]	Walsh RM, Crabtree GW, Kalpana K, Jubier	bioRxiv	2024
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149]	Fogaça MV, Wu M, Li C, Li XY, Picciotto	Mol Psychiatry	2021
Identification of epilepsy-associated neuronal subtypes and gene expression unde [PMID:33028830]	Pfisterer U, Petukhov V, Demharter S, Me	Nat Commun	2020
Meta-proteomics for the discovery of protein biomarkers of beef tenderness: An o [PMID:31882086]	Picard B, Gagaoua M	Food Res Int	2020

INTERNEURON

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Atypical Parkinsonism

calcium-dysregulation-comparison

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Therapeutics

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

GRIA3 Gene

Alzheimer's Disease

CNTN5 — Contactin 5

CLCN10 — Chloride Voltage-Gated Channel 10

Oligodendrocytes

ncam2

gabaergic-dysfunction

CNTN6 — Contactin 6

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

protective-strategies-cbs-psp

CNTN4 — Contactin 4

Cerebellar Function