cell_type

Interneuron

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Interneuron: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

423Connections

30Hypotheses

1Analyses

14Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	Interneuron
Definition	<table class="infobox infobox-cell">
Key Markers	EPILEPSY, PVALB, SST, SYNAPSE, INS, GAIN, NEURON, TAU
Key Pathways	Autophagy, Mapk, Wnt, Mtor, Glutamate Signaling
Associated Diseases	Aging, Neurodegeneration, Als, Alzheimer, Autism, Epilepsy
Linked Hypotheses	41 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    Interneuron["Interneuron"] -->|"expressed in"| Cortex["Cortex"]
    style Cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Interneuron["Interneuron"] -->|"expressed in"| Hippocampus["Hippocampus"]
    style Hippocampus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Interneuron["Interneuron"] -->|"expressed in"| Prefrontal_Cortex["Prefrontal Cortex"]
    style Prefrontal_Cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Interneuron["Interneuron"] -->|"expressed in"| Striatum["Striatum"]
    style Striatum fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Interneuron["Interneuron"] -->|"expressed in"| Temporal_Lobe["Temporal Lobe"]
    style Temporal_Lobe fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Interneuron["Interneuron"] -->|"expressed in"| Gray_Matter["Gray Matter"]
    style Gray_Matter fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Interneuron["Interneuron"] -->|"expressed in"| Basal_Ganglia["Basal Ganglia"]
    style Basal_Ganglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MEF2C["MEF2C"] -->|"regulates"| Interneuron["Interneuron"]
    style MEF2C fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CLPP["CLPP"] -->|"therapeutic target"| Interneuron["Interneuron"]
    style CLPP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    LONP1["LONP1"] -->|"therapeutic target"| Interneuron["Interneuron"]
    style LONP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SNAP29["SNAP29"] -->|"therapeutic target"| Interneuron["Interneuron"]
    style SNAP29 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    METTL3["METTL3"] -->|"therapeutic target"| Interneuron["Interneuron"]
    style METTL3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Interneuron fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (86)

Target	Relation	Type	Str
Cortex	expressed_in	brain_region	0.50
Hippocampus	expressed_in	brain_region	0.50
Prefrontal Cortex	expressed_in	brain_region	0.50
Striatum	expressed_in	brain_region	0.50
Temporal Lobe	expressed_in	brain_region	0.50
Gray Matter	expressed_in	brain_region	0.50
Basal Ganglia	expressed_in	brain_region	0.50
Caudate	expressed_in	brain_region	0.50
White Matter	expressed_in	brain_region	0.50
Dentate Gyrus	expressed_in	brain_region	0.50
Thalamus	expressed_in	brain_region	0.50
Entorhinal Cortex	expressed_in	brain_region	0.50
Amygdala	expressed_in	brain_region	0.50
Spinal Cord	expressed_in	brain_region	0.50

Incoming (337)

Source	Relation	Type	Str
MEF2C	regulates	gene	0.60
CLPP	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
YTHDF1	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
TDP-43	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
RAB5	inhibits	gene	0.60
MAPK	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
RAB11	inhibits	gene	0.60
AGING	therapeutic_target	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
NRG1	associated_with	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
APP	therapeutic_target	gene	0.60
CHR2	activates	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
RNA	contributes_to	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PVALB	therapeutic_target	gene	0.60
SST	therapeutic_target	gene	0.60
SYNAPSE	therapeutic_target	gene	0.60
SST	expressed_in	gene	0.60
INS	associated_with	gene	0.60
SST	associated_with	gene	0.60
GAIN	regulates	gene	0.60
SST	regulates	gene	0.60
PVALB	expressed_in	gene	0.60
EPILEPSY	associated_with	gene	0.60
PVALB	regulates	gene	0.60
NEURON	regulates	gene	0.60
TAU	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
FLT1	expressed_in	gene	0.60
REELIN	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
PVALB	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode

Beta-frequency entrainment therapy targeting PV interneuron-	0.669	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.660	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to	0.639	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Prefrontal sensory gating circuit restoration via PV interne	0.587	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass	0.576	neurodevelopment	How does SYNGAP1, a 'synaptic' protein,
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.569	neurodegeneration	What is the molecular mechanism by which
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.568	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode
Complement C1q Suppression as Mechanism Linking Exercise Pla	0.560	neurodegeneration	What are the specific circulating factor
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.527	neurodegeneration	What are the physiological functions of
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.497	neurodegeneration	Are interneuron oscillation deficits com
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.473	neurodegeneration	What molecular mechanisms underlie the d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361]	Han SC, Han J, Min YK, Han JW, Jeong HJ	Am J Sports Med	2026
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967]	Huang X, Francis I, Gu Y, Saha SC	Respir Physiol Neurobiol	2026
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313]	Samante FI, Galangue CG, Avelino DC, Bel	Pharmacol Rep	2026
Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213]	Wu J, Lin B, Yang S, Xu S, Li S	J Prosthet Dent	2026
Fate plasticity of interneuron specification. [PMID:40264797]	Mostajo-Radji MA, Leon WRM, Breevoort A,	iScience	2025
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610]	Gelot AB, Draia-Nicolau TO, Mathieu R, S	Epilepsia	2025
Brain connectivity and transcriptional changes induced by rTMS in first-episode [PMID:40274783]	Guan M, Xie Y, Wang Z, Miao Y, Li X et a	Transl Psychiatry	2025
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068]	Zhang C, Xie Z, Wang N	Am J Transl Res	2025
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024
Cortical assembloids support the development of fast-spiking human PVALB+ cortic [PMID:39651135]	Walsh RM, Crabtree GW, Kalpana K, Jubier	bioRxiv	2024
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149]	Fogaça MV, Wu M, Li C, Li XY, Picciotto	Mol Psychiatry	2021
Identification of epilepsy-associated neuronal subtypes and gene expression unde [PMID:33028830]	Pfisterer U, Petukhov V, Demharter S, Me	Nat Commun	2020
Meta-proteomics for the discovery of protein biomarkers of beef tenderness: An o [PMID:31882086]	Picard B, Gagaoua M	Food Res Int	2020

Interneuron

Understanding Entity Pages

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Atypical Parkinsonism

calcium-dysregulation-comparison

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Therapeutics

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

GRIA3 Gene

Alzheimer's Disease

CNTN5 — Contactin 5

CLCN10 — Chloride Voltage-Gated Channel 10

Oligodendrocytes

ncam2

gabaergic-dysfunction

CNTN6 — Contactin 6

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

protective-strategies-cbs-psp

CNTN4 — Contactin 4

Cerebellar Function