gene

KCNMA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNMA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

50Outgoing

45Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	KCNMA1
Full Name	Potassium Calcium-Activated Channel Subfamily M Alpha 1
Aliases	BK channel, SLO1, KCa1.1
Chromosome	10q22.3
Function	Large-conductance calcium-activated potassium channel (BK channel)
Molecular Weight	126.0 kDa
Amino Acids	1113
Exons	28 exons spanning the coding sequence
Pathways	Potassium transport, Neuronal excitability
UniProt ID	Q12791
Ensembl ID	ENSG00000156113
GeneCards	KCNMA1
Human Protein Atlas	KCNMA1
Genomic Size	~160 kb
Alternative Splicing	Multiple splice variants generate channel diversity [1]
Associated Diseases	Cancer
KG Connections	103 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KCNMA1 — AlphaFold Q12791 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KCNMA1["KCNMA1"] -->|"associated"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| TRPV1["TRPV1"]
    style TRPV1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| KCNN4["KCNN4"]
    style KCNN4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| KCNQ1["KCNQ1"]
    style KCNQ1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| CACNA1C["CACNA1C"]
    style CACNA1C fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    style Oxidative_Phosphorylation fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    KCNMA1["KCNMA1"] -->|"associated"| Wnt["Wnt"]
    style Wnt fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    PIEZO1["PIEZO1"] -->|"associated"| KCNMA1["KCNMA1"]
    style PIEZO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    KCNK2["KCNK2"] -->|"associated"| KCNMA1["KCNMA1"]
    style KCNK2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    SCN5A["SCN5A"] -->|"associated"| KCNMA1["KCNMA1"]
    style SCN5A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TRPM7["TRPM7"] -->|"associated"| KCNMA1["KCNMA1"]
    style TRPM7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    SCN1A["SCN1A"] -->|"associated"| KCNMA1["KCNMA1"]
    style SCN1A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style KCNMA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (58)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
TRPV1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
Axon Guidance	associated_with	pathway	0.60
KCNQ1	causes	gene	0.60
PIEZO1	causes	gene	0.60
CFTR	causes	gene	0.60
SCN1A	causes	gene	0.60
TRPA1	causes	gene	0.60
KCNN4	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
TRPV4	causes	gene	0.60
SCNN1A	causes	gene	0.60
TRPV1	causes	gene	0.60
KCNK2	causes	gene	0.60
CACNA1B	causes	gene	0.60
CACNA1C	causes	gene	0.60
TRPM7	causes	gene	0.60
PIEZO1	associated_with	entity	0.60
SCN5A	associated_with	entity	0.60
TRPA1	associated_with	entity	0.60
TRPM7	associated_with	entity	0.60
TRPV4	associated_with	entity	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
CANCER	associated_with	gene	0.60
HIPPO	associated_with	gene	0.60
AXON	associated_with	gene	0.60
TCR	associated_with	gene	0.60
GENES	causes	gene	0.60
AND	causes	gene	0.60
Macrophage	associated_with	cell_type	0.60
Monocyte	associated_with	cell_type	0.60
Fibroblast	associated_with	cell_type	0.60
Macrophage	expressed_in	cell_type	0.55
Fibroblast	expressed_in	cell_type	0.55
KCNN4	co_discussed	gene	0.50
KCNQ1	co_discussed	gene	0.50
PIEZO1	co_discussed	gene	0.50
PIEZO2	co_discussed	gene	0.50
SCN1A	co_discussed	gene	0.50
SCN5A	co_discussed	gene	0.50
SCNN1A	co_discussed	gene	0.50

Incoming (45)

Source	Relation	Type	Str
PIEZO1	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
TRPM7	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
SCNN1A	associated_with	gene	0.60
CFTR	associated_with	gene	0.60
PIEZO2	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPV1	associated_with	gene	0.60
PIEZO1	causes	gene	0.60
KCNK2	causes	gene	0.60
KCNQ1	causes	gene	0.60
CFTR	causes	gene	0.60
TRPV4	causes	gene	0.60
CACNA1B	causes	gene	0.60
TRPA1	causes	gene	0.60
TRPV1	causes	gene	0.60
PIEZO2	causes	gene	0.60
SCN5A	causes	gene	0.60
SCNN1A	causes	gene	0.60
SCN1A	causes	gene	0.60
CACNA1C	causes	gene	0.60
KCNN4	causes	gene	0.60
TRPM7	causes	gene	0.60
GENES	associated_with	gene	0.60
TCR	associated_with	gene	0.60
AXON	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AND	causes	gene	0.60
HIPPO	associated_with	gene	0.60
GENES	causes	gene	0.60
WNT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
CACNA1B	co_discussed	gene	0.50
CACNA1C	co_discussed	gene	0.50
CFTR	co_discussed	gene	0.50
KCNK2	co_discussed	gene	0.50
CANCER	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
ZO1	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KCNMA1

Understanding Entity Pages

Wiki Pages (20)

KCNMA1 Gene

Ion Channel Dysfunction in Huntington's Disease

Ion Channel Dysfunction in Alzheimer's Disease

potassium-channel-openers-parkinsons

HNRNPH2 Gene

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Interstitial Nucleus of the Vestibulospinal Tract (INV) Neurons

Section 145: Advanced Ion Channel Modulation and Channelopathy Therapy in CBS/PSP

KCNMB2

KCNMB4

KCA1A Gene

SCNN1A Gene

Potassium Channel Openers in Neurodegenerative Disease

KCNMA1 Protein (BK Channel)

KCNMB3

Motor Neurons in Amyotrophic Lateral Sclerosis

BK Channel Alpha Protein

KCNMB1 Gene