gene

SCN5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SCN5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

158Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

SCN5A is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 102 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSCN5A
Full NameSCN5A
Chromosome3p21
Protein TypeGene
Functionencodes a large transmembrane protein of 2016 amino acids forming the alpha subunit of the cardiac sodium channel.
Amino Acids2016 aa
Exons28
NCBI Gene IDSearch NCBI
GeneCardsSCN5A
Human Protein AtlasSCN5A
Associated DiseasesAging, Als, Alzheimer, Autism, Cancer, Carcinoma
KG Connections158 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

SCN5A Gene

gene · 1009 words

Voltage-Gated Sodium (NaV) Channel Neurons

cell · 1998 words

SCN10A Gene

gene · 1894 words

RBM25 (RNA Binding Motif 25)

gene · 1728 words

KCNMA1 Gene

gene · 1671 words

KCNN4 — Potassium Calcium-Activated Channel Subfamily N Member 4

gene · 1374 words

Pathway Diagram

graph TD
    SCN5A["SCN5A"] -->|"associated"| Cancer["Cancer"]
    SCN5A["SCN5A"] -->|"therapeutic target"| Als["Als"]
    SCN5A["SCN5A"] -->|"therapeutic target"| Cardiac["Cardiac"]
    SCN5A["SCN5A"] -->|"therapeutic target"| Ms["Ms"]
    SCN5A["SCN5A"] -->|"associated"| TRPM7["TRPM7"]
    SCN5A["SCN5A"] -->|"associated"| SCN1A["SCN1A"]
    PIEZO1["PIEZO1"] -->|"associated"| SCN5A["SCN5A"]
    KCNK2["KCNK2"] -->|"associated"| SCN5A["SCN5A"]
    CACNA1B["CACNA1B"] -->|"associated"| SCN5A["SCN5A"]
    CACNA1C["CACNA1C"] -->|"associated"| SCN5A["SCN5A"]
    style SCN5A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (87)

TargetRelationTypeStr
Ovarian Cancerassociated_withdisease0.80
Ovarian Cancerbiomarker_fordisease0.80
Cancerassociated_withdisease0.65
Alstherapeutic_targetdisease0.65
Cardiactherapeutic_targetdisease0.65

Incoming (71)

SourceRelationTypeStr
PIEZO1associated_withgene0.60
KCNK2associated_withgene0.60
CACNA1Bassociated_withgene0.60
CACNA1Cassociated_withgene0.60
CFTRassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found