Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCN5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SCN5A is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 102 entities in the SciDEX knowledge graph.
| Gene Symbol | SCN5A |
| Full Name | SCN5A |
| Chromosome | 3p21 |
| Protein Type | Gene |
| Function | encodes a large transmembrane protein of 2016 amino acids forming the alpha subunit of the cardiac sodium channel. |
| Amino Acids | 2016 aa |
| Exons | 28 |
| NCBI Gene ID | Search NCBI |
| GeneCards | SCN5A |
| Human Protein Atlas | SCN5A |
| Associated Diseases | Aging, Als, Alzheimer, Autism, Cancer, Carcinoma |
| KG Connections | 158 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
SCN5A["SCN5A"] -->|"associated"| Cancer["Cancer"]
SCN5A["SCN5A"] -->|"therapeutic target"| Als["Als"]
SCN5A["SCN5A"] -->|"therapeutic target"| Cardiac["Cardiac"]
SCN5A["SCN5A"] -->|"therapeutic target"| Ms["Ms"]
SCN5A["SCN5A"] -->|"associated"| TRPM7["TRPM7"]
SCN5A["SCN5A"] -->|"associated"| SCN1A["SCN1A"]
PIEZO1["PIEZO1"] -->|"associated"| SCN5A["SCN5A"]
KCNK2["KCNK2"] -->|"associated"| SCN5A["SCN5A"]
CACNA1B["CACNA1B"] -->|"associated"| SCN5A["SCN5A"]
CACNA1C["CACNA1C"] -->|"associated"| SCN5A["SCN5A"]
style SCN5A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ovarian Cancer | associated_with | disease | 0.80 |
| Ovarian Cancer | biomarker_for | disease | 0.80 |
| Cancer | associated_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Cardiac | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Hypertension | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| TRPM7 | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| TRPV4 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| SCNN1A | associated_with | gene | 0.60 |
| CFTR | associated_with | gene | 0.60 |
| PIEZO2 | associated_with | gene | 0.60 |
| TRPA1 | associated_with | gene | 0.60 |
| KCNMA1 | associated_with | gene | 0.60 |
| TRPV1 | associated_with | gene | 0.60 |
| KCNN4 | associated_with | gene | 0.60 |
| KCNQ1 | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| PIEZO1 | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| Axon Guidance | associated_with | pathway | 0.60 |
| IL1B | therapeutic_target | gene | 0.60 |
| KCNQ1 | therapeutic_target | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| CALM1 | therapeutic_target | gene | 0.60 |
| LMNA | therapeutic_target | gene | 0.60 |
| HRAS | therapeutic_target | gene | 0.60 |
| DRD2 | therapeutic_target | gene | 0.60 |
| PPARG | therapeutic_target | gene | 0.60 |
| IDH2 | therapeutic_target | gene | 0.60 |
| TRPV4 | causes | gene | 0.60 |
| SCNN1A | causes | gene | 0.60 |
| TRPV1 | causes | gene | 0.60 |
| KCNK2 | causes | gene | 0.60 |
| CACNA1B | causes | gene | 0.60 |
| CACNA1C | causes | gene | 0.60 |
| TRPM7 | causes | gene | 0.60 |
| PAH | associated_with | gene | 0.60 |
| CFTR | causes | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIEZO1 | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CFTR | associated_with | gene | 0.60 |
| TRPV4 | associated_with | gene | 0.60 |
| KCNQ1 | associated_with | gene | 0.60 |
| TRPA1 | associated_with | gene | 0.60 |
| TRPV1 | associated_with | gene | 0.60 |
| TRPM7 | associated_with | gene | 0.60 |
| KCNH2 | therapeutic_target | gene | 0.60 |
| IDH1 | therapeutic_target | gene | 0.60 |
| TP53 | therapeutic_target | gene | 0.60 |
| KCNMA1 | causes | gene | 0.60 |
| KCNQ1 | causes | gene | 0.60 |
| PIEZO1 | causes | gene | 0.60 |
| CFTR | causes | gene | 0.60 |
| SCN1A | causes | gene | 0.60 |
| TRPA1 | causes | gene | 0.60 |
| KCNN4 | causes | gene | 0.60 |
| PIEZO2 | causes | gene | 0.60 |
| KCNK2 | causes | gene | 0.60 |
| TRPV4 | causes | gene | 0.60 |
| CACNA1B | causes | gene | 0.60 |
| CACNA1C | causes | gene | 0.60 |
| TRPM7 | causes | gene | 0.60 |
| SCNN1A | causes | gene | 0.60 |
| TRPV1 | causes | gene | 0.60 |
| EPAS1 | associated_with | gene | 0.60 |
| MYC | associated_with | gene | 0.60 |
| CALM1 | therapeutic_target | gene | 0.60 |
| HRAS | therapeutic_target | gene | 0.60 |
| IL1B | therapeutic_target | gene | 0.60 |
| KCNQ1 | therapeutic_target | gene | 0.60 |
| DRD2 | therapeutic_target | gene | 0.60 |
| IDH2 | therapeutic_target | gene | 0.60 |
| KCNMA1 | associated_with | entity | 0.60 |
| KCNN4 | associated_with | entity | 0.60 |
| PIEZO2 | associated_with | entity | 0.60 |
| SCN1A | associated_with | entity | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| HIPPO | associated_with | gene | 0.60 |
| AXON | associated_with | gene | 0.60 |
| TCR | associated_with | gene | 0.60 |
| GENES | causes | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| GENETIC MODIFIERS | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||