gene

KCNQ1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNQ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

154Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

KCNQ1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, causes. Associated with Als, Cancer, Cardiac. Connected to 98 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolKCNQ1
Full NamePotassium Voltage-Gated Channel Subfamily Q Member 1
AliasesKV7.1
Chromosome11p15.5.
Protein TypeChannel
FunctionKCNQ1 channels perform essential functions in various tissues:
Molecular Weight~75 kDa
Amino Acids676 aa
Exons19
PathwaysWnt/β-catenin signaling
UniProt IDP51787
NCBI Gene ID3785
Ensembl IDENSG00000143338
OMIM607542
GeneCardsKCNQ1
Human Protein AtlasKCNQ1
Associated DiseasesCancer, Ovarian Cancer
InteractionsKCNE1, KCNE3
KG Connections154 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: KCNQ1 — AlphaFold P51787 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

KCNQ1 (KV7.1)

gene · 935 words

Kv7.3 Potassium Channel

protein · 3781 words

USH1C Gene

gene · 2382 words

Schwann Cells

cell · 2252 words

KCNE3 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 3)

gene · 1987 words

KCNMA1 Gene

gene · 1671 words

Pathway Diagram

graph TD
    KCNQ1["KCNQ1"]
    KCNQ1 -->|"interacts"| KCNE1["KCNE1"]
    KCNQ1 -->|"regulates"| Wnt___catenin_signaling["Wnt/beta-catenin signaling"]
    KCNQ1 -->|"binds"| KCNE3["KCNE3"]
    KCNQ1 -->|"binds"| PIP2["PIP2"]
    KCNQ1 -->|"binds"| beta_tubulin["beta-tubulin"]
    KCNQ1 -->|"activates"| MET_receptor["MET receptor"]
    KCNQ1 -->|"downregulates"| DKK_1["DKK-1"]
    KCNQ1 -->|"downregulates"| Wif_1["Wif-1"]
    KCNQ1 -->|"downregulates"| NKD_1["NKD-1"]
    KCNQ1 -->|"upregulates"| Cdkn1c["Cdkn1c"]
    HRH2["HRH2"] -->|"upregulates"| KCNQ1
    KCNE3 -->|"modulates"| KCNQ1
    KCNH2["KCNH2"] -->|"target for"| KCNQ1
    IDH1["IDH1"] -->|"target for"| KCNQ1
    TP53["TP53"] -->|"target for"| KCNQ1
    SCN5A["SCN5A"] -->|"target for"| KCNQ1
    IL1B["IL1B"] -->|"target for"| KCNQ1
    KCNMA1["KCNMA1"] -->|"causes"| KCNQ1

Outgoing (93)

TargetRelationTypeStr
KCNE1interacts_withgene0.90
Wnt/β-catenin signalingregulatespathway0.90
KCNE3bindsgene0.80
PIP2bindschemical0.80
beta-tubulinbindsprotein0.80

Incoming (61)

SourceRelationTypeStr
KCNE3modulatesgene0.80
KCNE3regulatesgene0.80
KCNE3activatesgene0.80
PIEZO1associated_withgene0.60
KCNK2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found