Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNQ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNQ1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, causes. Associated with Als, Cancer, Cardiac. Connected to 98 entities in the SciDEX knowledge graph.
| Gene Symbol | KCNQ1 |
| Full Name | Potassium Voltage-Gated Channel Subfamily Q Member 1 |
| Aliases | KV7.1 |
| Chromosome | 11p15.5. |
| Protein Type | Channel |
| Function | KCNQ1 channels perform essential functions in various tissues: |
| Molecular Weight | ~75 kDa |
| Amino Acids | 676 aa |
| Exons | 19 |
| Pathways | Wnt/β-catenin signaling |
| UniProt ID | P51787 |
| NCBI Gene ID | 3785 |
| Ensembl ID | ENSG00000143338 |
| OMIM | 607542 |
| GeneCards | KCNQ1 |
| Human Protein Atlas | KCNQ1 |
| Associated Diseases | Cancer, Ovarian Cancer |
| Interactions | KCNE1, KCNE3 |
| KG Connections | 154 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNQ1["KCNQ1"]
KCNQ1 -->|"interacts"| KCNE1["KCNE1"]
KCNQ1 -->|"regulates"| Wnt___catenin_signaling["Wnt/beta-catenin signaling"]
KCNQ1 -->|"binds"| KCNE3["KCNE3"]
KCNQ1 -->|"binds"| PIP2["PIP2"]
KCNQ1 -->|"binds"| beta_tubulin["beta-tubulin"]
KCNQ1 -->|"activates"| MET_receptor["MET receptor"]
KCNQ1 -->|"downregulates"| DKK_1["DKK-1"]
KCNQ1 -->|"downregulates"| Wif_1["Wif-1"]
KCNQ1 -->|"downregulates"| NKD_1["NKD-1"]
KCNQ1 -->|"upregulates"| Cdkn1c["Cdkn1c"]
HRH2["HRH2"] -->|"upregulates"| KCNQ1
KCNE3 -->|"modulates"| KCNQ1
KCNH2["KCNH2"] -->|"target for"| KCNQ1
IDH1["IDH1"] -->|"target for"| KCNQ1
TP53["TP53"] -->|"target for"| KCNQ1
SCN5A["SCN5A"] -->|"target for"| KCNQ1
IL1B["IL1B"] -->|"target for"| KCNQ1
KCNMA1["KCNMA1"] -->|"causes"| KCNQ1| Target | Relation | Type | Str |
|---|---|---|---|
| KCNE1 | interacts_with | gene | 0.90 |
| Wnt/β-catenin signaling | regulates | pathway | 0.90 |
| KCNE3 | binds | gene | 0.80 |
| PIP2 | binds | chemical | 0.80 |
| beta-tubulin | binds | protein | 0.80 |
| MET receptor | activates | receptor | 0.80 |
| DKK-1 | downregulates | gene | 0.80 |
| Wif-1 | downregulates | gene | 0.80 |
| NKD-1 | downregulates | gene | 0.80 |
| Cdkn1c | upregulates | gene | 0.80 |
| Kcnq1ot1 | regulates | gene | 0.80 |
| Insulin secretion | regulates | biological_process | 0.80 |
| Ovarian Cancer | associated_with | disease | 0.80 |
| Ovarian Cancer | biomarker_for | disease | 0.80 |
| Ovarian Cancer | risk_factor_for | disease | 0.80 |
| Ovarian Cancer | implicated_in | disease | 0.72 |
| Wnt/β-catenin signaling | interacts_with | pathway | 0.70 |
| Pdx1 | regulates | gene | 0.70 |
| Cancer | associated_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Cardiac | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| CACNA1C | associated_with | gene | 0.60 |
| TRPA1 | associated_with | gene | 0.60 |
| TRPV1 | associated_with | gene | 0.60 |
| TRPM7 | associated_with | gene | 0.60 |
| SCN5A | associated_with | gene | 0.60 |
| PIEZO1 | associated_with | gene | 0.60 |
| KCNMA1 | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| SCNN1A | associated_with | gene | 0.60 |
| PIEZO2 | associated_with | gene | 0.60 |
| KCNN4 | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| Axon Guidance | associated_with | pathway | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| CALM1 | therapeutic_target | gene | 0.60 |
| LMNA | therapeutic_target | gene | 0.60 |
| HRAS | therapeutic_target | gene | 0.60 |
| DRD2 | therapeutic_target | gene | 0.60 |
| PPARG | therapeutic_target | gene | 0.60 |
| IDH2 | therapeutic_target | gene | 0.60 |
| PIEZO1 | causes | gene | 0.60 |
| CFTR | causes | gene | 0.60 |
| SCN1A | causes | gene | 0.60 |
| TRPA1 | causes | gene | 0.60 |
| KCNN4 | causes | gene | 0.60 |
| PIEZO2 | causes | gene | 0.60 |
| SCN5A | causes | gene | 0.60 |
| TRPV4 | causes | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| KCNE3 | modulates | gene | 0.80 |
| KCNE3 | regulates | gene | 0.80 |
| KCNE3 | activates | gene | 0.80 |
| PIEZO1 | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| SCN5A | associated_with | gene | 0.60 |
| TRPM7 | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| TRPV4 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| SCNN1A | associated_with | gene | 0.60 |
| CFTR | associated_with | gene | 0.60 |
| PIEZO2 | associated_with | gene | 0.60 |
| TRPA1 | associated_with | gene | 0.60 |
| KCNMA1 | associated_with | gene | 0.60 |
| TRPV1 | associated_with | gene | 0.60 |
| KCNN4 | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| KCNH2 | therapeutic_target | gene | 0.60 |
| IDH1 | therapeutic_target | gene | 0.60 |
| TP53 | therapeutic_target | gene | 0.60 |
| SCN5A | therapeutic_target | gene | 0.60 |
| IL1B | therapeutic_target | gene | 0.60 |
| KCNMA1 | causes | gene | 0.60 |
| PIEZO1 | causes | gene | 0.60 |
| KCNK2 | causes | gene | 0.60 |
| CALM1 | therapeutic_target | gene | 0.60 |
| HRAS | therapeutic_target | gene | 0.60 |
| CACNA1B | causes | gene | 0.60 |
| TRPA1 | causes | gene | 0.60 |
| TRPV1 | causes | gene | 0.60 |
| PIEZO2 | causes | gene | 0.60 |
| SCN5A | causes | gene | 0.60 |
| CFTR | causes | gene | 0.60 |
| SCNN1A | causes | gene | 0.60 |
| SCN1A | causes | gene | 0.60 |
| CACNA1C | causes | gene | 0.60 |
| KCNN4 | causes | gene | 0.60 |
| TRPV4 | causes | gene | 0.60 |
| TRPM7 | causes | gene | 0.60 |
| TCR | associated_with | gene | 0.60 |
| AXON | associated_with | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| CIRCADIAN RHYTHM | therapeutic_target | gene | 0.60 |
| ACHE | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| AND | causes | gene | 0.60 |
| HIPPO | associated_with | gene | 0.60 |
| GENES | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||