concept

LIPID RAFT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIPID RAFT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

7Hypotheses

0Analyses

28Outgoing

30Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LIPID RAFT
Key Genes/Proteins	ABCA1, ABCG1, ADAM10, AKT, AMYLOID, APOE
Related Diseases	ACETYLCHOLINE, ALZHEIMER, ALZHEIMER'S DISEASE, AUTOPHAGY

Pathway Diagram

graph TD
    LIPID_RAFT[LIPID RAFT]
    LIPID_RAFT -->|inhibits| BDNF[BDNF]
    LIPID_RAFT -->|targets| ALZHEIMER_S_DISEASE[ALZHEIMER'S DISEASE]
    LIPID_RAFT -->|expressed in| CHOLESTEROL[CHOLESTEROL]
    BACE1[BACE1] -->|interacts| LIPID_RAFT
    APOE[APOE] -->|regulates| LIPID_RAFT
    MICROGLIA[MICROGLIA] -->|destabilizes| LIPID_RAFT
    INFLAMMATION[INFLAMMATION] -->|destabilizes| LIPID_RAFT

Outgoing (28)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	targets	disease	0.60
ALZHEIMER'S DISEASE	inhibits	disease	0.60
BDNF	inhibits	gene	0.60
CHOLESTEROL	expressed_in	phenotype	0.55
AUTOPHAGY	associated_with	phenotype	0.50
STROKE	associated_with	disease	0.50
DEMENTIA	associated_with	disease	0.50
DOPAMINE	associated_with	phenotype	0.50
GLUTAMATE	associated_with	phenotype	0.50
CERAMIDE	associated_with	phenotype	0.50
NEURONS	associated_with	cell_type	0.50
ASTROCYTE	associated_with	cell_type	0.50
CYP46A1	associated_with	gene	0.50
ABCA1	associated_with	gene	0.50
ABCG1	associated_with	gene	0.50
AKT	associated_with	gene	0.50
ADAM10	associated_with	gene	0.50
APOE	associated_with	gene	0.50
TAU	associated_with	protein	0.50
BDNF	associated_with	gene	0.50
TLR4	associated_with	gene	0.50
TH	associated_with	gene	0.50
AMYLOID	associated_with	protein	0.45
ALZHEIMER	associated_with	disease	0.45
HMGCR	associated_with	gene	0.45
BACE1	associated_with	gene	0.45
APP	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45

Incoming (30)

Source	Relation	Type	Str
BACE1	interacts_with	gene	0.65
BACE1	regulates	gene	0.60
BACE1	activates	gene	0.60
BACE1	stabilizes	gene	0.60
INFLAMMATION	associated_with	phenotype	0.60
APOE	regulates	gene	0.60
APOE	stabilizes	gene	0.60
APOE	targets	gene	0.60
APOE	destabilizes	gene	0.60
MICROGLIA	destabilizes	cell_type	0.60
NEURONS	interacts_with	cell_type	0.60
CHOLESTEROL	stabilizes	phenotype	0.60
CHOLESTEROL	associated_with	phenotype	0.60
APOE	implicated_in	gene	0.55
CERAMIDE	implicated_in	phenotype	0.55
HEPATOCYTES	associated_with	cell_type	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
LIPID METABOLISM	associated_with	phenotype	0.50
LONG-TERM POTENTIATION	associated_with	phenotype	0.50
SYNAPTIC PLASTICITY	associated_with	phenotype	0.50
DEPRESSION	associated_with	disease	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
ASTROCYTES	associated_with	cell_type	0.50
LONG-TERM DEPRESSION	associated_with	phenotype	0.50
SPHINGOLIPIDS	associated_with	phenotype	0.50
ACETYLCHOLINE	associated_with	phenotype	0.50
PROTEIN CLEARANCE	associated_with	phenotype	0.50
CELL DEATH	associated_with	phenotype	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE-Mediated Synaptic Lipid Raft Stabilization	0.649	neurodegeneration	Mechanistic role of APOE in neurodegener
Glucosylceramide accumulation nucleates alpha-synuclein aggr	0.525	parkinsons	GBA-Synuclein Loop Therapeutics for PD
Membrane Lipid Raft Reorganization Therapy	0.000	-	What determines the selectivity and effi
Cholinergic-Lipid Raft Interface Modulators	0.000	-	Lipid raft composition changes in synapt
Nicotinic Receptor-Lipid Raft Co-Modulators	0.000	-	Lipid raft composition changes in synapt

Lipid Raft Autophagy Receptor Reorganization	0.000	-	Autophagy-lysosome pathway convergence a
Lipid Raft Disruptors with Membrane Fluidizers	0.000	-	GBA-Synuclein Loop Therapeutics for PD

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell-Type Dependent and [PMID:41806112]	Mrkacek M, Tumova M, Puskasu A, Utekal P	FASEB journal : official publi	2026
Lipidome Plasticity Preserves Membrane Function in Sphingolipid-Depleted HAP1 Ce [PMID:41239795]	Monasterio BG, García-Arribas AB, Riezma	FASEB journal : official publi	2025
Sphingomyelin synthase-related protein is a regulator of serine palmitoyltransfe [PMID:40998032]	Li X, Li Z, Chiang YP, Worgall T, Souaia	Journal of lipid research	2025
Recurrent de novo [PMID:38041679]	["Syeda S", "Lone M", "Mohassel P", "Don	Journal of neurology, neurosur	2024
Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010]	Torrini C, Nguyen TTT, Shu C, Mela A, Hu	Molecular cell	2022
Calcium-Mediated Calpain Activation and Microtubule Dissociation in Cell Model o [PMID:34986032]	["Antony A", "Ng N", "Lauto A", "Coorsse	DNA and cell biology	2022
Precision mouse models of Yars/dominant intermediate Charcot-Marie-Tooth disease [PMID:34875719]	["Hines T", "Tadenev A", "Lone M", "Hatt	Journal of anatomy	2022
Re-identification of individuals in genomic datasets using public face images. [PMID:34788101]	Venkatesaramani R, Malin BA, Vorobeychik	Science advances	2021
Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Scl [PMID:34459874]	Johnson JO, Chia R, Miller DE, Li R, Kum	JAMA neurology	2021
Cryo-EM structures of Toll-like receptors in complex with UNC93B1. [PMID:33432245]	Ishida H, Asami J, Zhang Z, Nishizawa T,	Nature structural & molecular	2021
Assessing Cochlear Implant Performance in Older Adults Using a Single, Universal [PMID:30001281]	Sharma RK, Chen SY, Grisel J, Golub JS	Otology & neurotology : offici	2018
PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Su [PMID:28122242]	Lee Y, Stevens DA, Kang SU, Jiang H, Lee	Cell reports	2017
Molecular genetics of hereditary sensory neuropathies. [PMID:16775373]	["Auer-Grumbach M", "Mauko B", "Auer-Gru	Neuromolecular medicine	2006
1.6-Angstroms crystal structure of EntA-im. A bacterial immunity protein conferr [PMID:15753083]	Johnsen L, Dalhus B, Leiros I, Nissen-Me	The Journal of biological chem	2005

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LIPID RAFT in their description or question text

Lipid Raft Autophagy Receptor Reorganization

Score: 0.000 · unknown disease · 2026-04-28

Therapeutic modulation of membrane lipid composition to restore efficient autophagosome formation and cargo selectivity

Lipid Raft Disruptors with Membrane Fluidizers

Score: 0.000 · unknown disease · 2026-04-28

Using targeted membrane fluidizers to disrupt lipid raft environments where GCase and alpha-synuclein interact pathologi