Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LIPID RAFT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| BDNF | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | targets | disease | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | disease | 0.60 |
| CHOLESTEROL | expressed_in | phenotype | 0.55 |
| TAU | associated_with | protein | 0.50 |
| CYP46A1 | associated_with | gene | 0.50 |
| ABCA1 | associated_with | gene | 0.50 |
| ABCG1 | associated_with | gene | 0.50 |
| AKT | associated_with | gene | 0.50 |
| ADAM10 | associated_with | gene | 0.50 |
| APOE | associated_with | gene | 0.50 |
| BDNF | associated_with | gene | 0.50 |
| TLR4 | associated_with | gene | 0.50 |
| TH | associated_with | gene | 0.50 |
| GLUTAMATE | associated_with | phenotype | 0.50 |
| CERAMIDE | associated_with | phenotype | 0.50 |
| AUTOPHAGY | associated_with | phenotype | 0.50 |
| STROKE | associated_with | disease | 0.50 |
| DEMENTIA | associated_with | disease | 0.50 |
| NEURONS | associated_with | cell_type | 0.50 |
| ASTROCYTE | associated_with | cell_type | 0.50 |
| DOPAMINE | associated_with | phenotype | 0.50 |
| HMGCR | associated_with | gene | 0.45 |
| BACE1 | associated_with | gene | 0.45 |
| APP | associated_with | gene | 0.45 |
| ALZHEIMER | associated_with | disease | 0.45 |
| AMYLOID | associated_with | protein | 0.45 |
| MICROGLIA | associated_with | cell_type | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BACE1 | interacts_with | gene | 0.65 |
| BACE1 | activates | gene | 0.60 |
| BACE1 | stabilizes | gene | 0.60 |
| BACE1 | regulates | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
| APOE | stabilizes | gene | 0.60 |
| APOE | targets | gene | 0.60 |
| APOE | destabilizes | gene | 0.60 |
| MICROGLIA | destabilizes | cell_type | 0.60 |
| INFLAMMATION | destabilizes | phenotype | 0.60 |
| NEURONS | interacts_with | cell_type | 0.60 |
| CHOLESTEROL | destabilizes | phenotype | 0.60 |
| CHOLESTEROL | stabilizes | phenotype | 0.60 |
| APOE | implicated_in | gene | 0.55 |
| CHOLESTEROL | implicated_in | phenotype | 0.55 |
| CERAMIDE | implicated_in | phenotype | 0.55 |
| PROTEIN CLEARANCE | associated_with | phenotype | 0.50 |
| ACETYLCHOLINE | associated_with | phenotype | 0.50 |
| LONG-TERM DEPRESSION | associated_with | phenotype | 0.50 |
| SPHINGOLIPIDS | associated_with | phenotype | 0.50 |
| NEURODEGENERATION | associated_with | phenotype | 0.50 |
| ASTROCYTES | associated_with | cell_type | 0.50 |
| HEPATOCYTES | associated_with | cell_type | 0.50 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.50 |
| CELL DEATH | associated_with | phenotype | 0.50 |
| LONG-TERM POTENTIATION | associated_with | phenotype | 0.50 |
| SYNAPTIC PLASTICITY | associated_with | phenotype | 0.50 |
| DEPRESSION | associated_with | disease | 0.50 |
| LIPID METABOLISM | associated_with | phenotype | 0.50 |
| CHOLESTEROL | associated_with | phenotype | 0.45 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE-Mediated Synaptic Lipid Raft Stabilization | 0.426 | neurodegeneration | Mechanistic role of APOE in neurodegener |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell-Type Dependent and [PMID:41806112] | Mrkacek M, Tumova M, Puskasu A, Utekal P | FASEB journal : official publi | 2026 | 0 |
| Lipidome Plasticity Preserves Membrane Function in Sphingolipid-Depleted HAP1 Ce [PMID:41239795] | Monasterio BG, García-Arribas AB, Riezma | FASEB journal : official publi | 2025 | 0 |
| Sphingomyelin synthase-related protein is a regulator of serine palmitoyltransfe [PMID:40998032] | Li X, Li Z, Chiang YP, Worgall T, Souaia | Journal of lipid research | 2025 | 0 |
| Recurrent de novo [PMID:38041679] | ["Syeda S", "Lone M", "Mohassel P", "Don | Journal of neurology, neurosur | 2024 | 0 |
| Lactate is an epigenetic metabolite that drives survival in model systems of gli [PMID:35948010] | Torrini C, Nguyen TTT, Shu C, Mela A, Hu | Molecular cell | 2022 | 0 |
| Calcium-Mediated Calpain Activation and Microtubule Dissociation in Cell Model o [PMID:34986032] | ["Antony A", "Ng N", "Lauto A", "Coorsse | DNA and cell biology | 2022 | 0 |
| Precision mouse models of Yars/dominant intermediate Charcot-Marie-Tooth disease [PMID:34875719] | ["Hines T", "Tadenev A", "Lone M", "Hatt | Journal of anatomy | 2022 | 0 |
| Re-identification of individuals in genomic datasets using public face images. [PMID:34788101] | Venkatesaramani R, Malin BA, Vorobeychik | Science advances | 2021 | 0 |
| Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Scl [PMID:34459874] | Johnson JO, Chia R, Miller DE, Li R, Kum | JAMA neurology | 2021 | 0 |
| Cryo-EM structures of Toll-like receptors in complex with UNC93B1. [PMID:33432245] | Ishida H, Asami J, Zhang Z, Nishizawa T, | Nature structural & molecular | 2021 | 0 |
| Assessing Cochlear Implant Performance in Older Adults Using a Single, Universal [PMID:30001281] | Sharma RK, Chen SY, Grisel J, Golub JS | Otology & neurotology : offici | 2018 | 0 |
| PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Su [PMID:28122242] | Lee Y, Stevens DA, Kang SU, Jiang H, Lee | Cell reports | 2017 | 0 |
| Molecular genetics of hereditary sensory neuropathies. [PMID:16775373] | ["Auer-Grumbach M", "Mauko B", "Auer-Gru | Neuromolecular medicine | 2006 | 0 |
| 1.6-Angstroms crystal structure of EntA-im. A bacterial immunity protein conferr [PMID:15753083] | Johnsen L, Dalhus B, Leiros I, Nissen-Me | The Journal of biological chem | 2005 | 0 |