WRN

Understanding Entity Pages

This page aggregates everything SciDEX knows about WRN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for WRN Protein - Werner Syndrome RecQ Like Helicase

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graph TD
    WRN["<b>WRN</b>"]
    Aging{"Aging"}
    WRN -->|"associated with"| Aging
    Ms{"Ms"}
    WRN -->|"therapeutic target"| Ms
    Senescence{"Senescence"}
    WRN -->|"associated with"| Senescence
    WRN -->|"associated with"| Ms
    DNA["DNA"]
    WRN -->|"associated with"| DNA
    Mitophagy(["Mitophagy"])
    WRN -->|"therapeutic target"| Mitophagy
    MDM2["MDM2"]
    WRN -->|"interacts with"| MDM2
    CTC1["CTC1"]
    WRN -->|"interacts with"| CTC1
    ATM["ATM"]
    WRN -->|"regulates"| ATM
    Complement(["Complement"])
    WRN -->|"interacts with"| Complement
    neurodegeneration["neurodegeneration"]
    WRN -->|"implicated in"| neurodegeneration
    TREX1["TREX1"]
    TREX1 -->|"interacts with"| WRN
    VCP["VCP"]
    VCP -->|"interacts with"| WRN
    NEIL1["NEIL1"]
    NEIL1 -->|"interacts with"| WRN
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| WRN
    POLD1["POLD1"]
    POLD1 -->|"interacts with"| WRN
    P53["P53"]
    P53 -->|"interacts with"| WRN
    POT1["POT1"]
    POT1 -->|"interacts with"| WRN
    MRE11["MRE11"]
    MRE11 -->|"interacts with"| WRN
    MUTYH["MUTYH"]
    MUTYH -->|"interacts with"| WRN
    SAMHD1["SAMHD1"]
    SAMHD1 -->|"interacts with"| WRN
    NBS1["NBS1"]
    NBS1 -->|"interacts with"| WRN
    LMNA["LMNA"]
    LMNA -->|"interacts with"| WRN
    style WRN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0