gene

NRBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

0Hypotheses

0Analyses

40Outgoing

19Incoming

Summary

Page for NRBP1 - Nuclear Receptor Binding Protein 1

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🧬 Gene Info

Gene Symbol	NRBP1
Full Name	Nuclear Receptor Binding Protein 1
Aliases	Page for NRBP1
Protein Type	Receptor
Function	NRBP1 (Nuclear Receptor Binding Protein 1) is a conserved eukaryotic protein that functions as a transcriptional co-regulator and scaffold protein.
Pathways	NF-κB, WNT, wnt, MAPK
Ensembl ID	ENSG00000130726
GeneCards	NRBP1
Human Protein Atlas	NRBP1
Cell Signaling Hub	NRBP1 integrates signals from multiple pathways including NF-κB, WNT, and MAPK cascades. It modulates downstream transcriptional outputs in response to cellular stress.
Cell Cycle Regulation	The protein participates in cell cycle control through interactions with cyclin-dependent kinases and cell cycle regulators. Dysregulation can lead to abnormal proliferation or cell death.
Mitochondrial Function	NRBP1 localizes to mitochondria under stress conditions and influences mitochondrial dynamics, apoptosis, and cellular energy metabolism.
Brain	Cortex, hippocampus, basal ganglia
Liver and kidney	High metabolic activity tissues
Pancreas	Islet cells
Associated Diseases	depression
Known Drugs/Compounds	R-ketamine
Interactions	BDNF, CSF1R, MECP2, Rb, ERK, DNA
KG Connections	59 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NRBP1["<b>NRBP1</b>"]
    ERK["ERK"]
    NRBP1 -->|"participates in"| ERK
    CREB["CREB"]
    NRBP1 -->|"participates in"| CREB
    BDNF["BDNF"]
    NRBP1 -->|"participates in"| BDNF
    n_4E_BP["4E-BP"]
    NRBP1 -->|"regulates"| n_4E_BP
    S6_kinase["S6-kinase"]
    NRBP1 -->|"regulates"| S6_kinase
    Ms{"Ms"}
    NRBP1 -->|"inhibits"| Ms
    Depression{"Depression"}
    NRBP1 -->|"inhibits"| Depression
    NRBP1 -->|"activates"| BDNF
    CSF1R["CSF1R"]
    NRBP1 -->|"inhibits"| CSF1R
    MECP2["MECP2"]
    NRBP1 -->|"inhibits"| MECP2
    NRBP1 -->|"activates"| ERK
    DNA["DNA"]
    NRBP1 -->|"inhibits"| DNA
    R_ketamine["R-ketamine"]
    R_ketamine -->|"activates"| NRBP1
    NEURON["NEURON"]
    NEURON -->|"expressed in"| NRBP1
    style NRBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
BDNF	participates_in	protein	0.80
4E-BP	regulates	protein	0.80
S6-kinase	regulates	protein	0.80
ERK	participates_in	protein	0.80
DEPRESSION	biomarker_for	disease	0.80
Ms	inhibits	disease	0.65
Depression	inhibits	disease	0.65
BDNF	activates	gene	0.60
CSF1R	inhibits	gene	0.60
MECP2	inhibits	gene	0.60
Dendritic Spine	inhibits	pathway	0.60
Rb	activates	protein	0.60
depression	interacts_with	disease	0.60
depression	associated_with	disease	0.60
ERK	activates	gene	0.60
DNA	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
CREB	activates	gene	0.60
DEPRESSION	inhibits	gene	0.60
NEURON	expressed_in	gene	0.60
Microglia	activates	cell_type	0.60
RNA	inhibits	gene	0.60
AND	activates	gene	0.60
Actin	inhibits	protein	0.60
Bdnf	activates	protein	0.60
astrocytes	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
cortex	expressed_in	brain_region	0.60
Prefrontal Cortex	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
CREB	associated_with	protein	0.50
Astrocyte	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Cortex	associated_with	brain_region	0.50
PREFRONTAL CORTEX	associated_with	concept	0.50

Incoming (19)

Source	Relation	Type	Str
R-ketamine	activates	drug	0.70
BDNF	phosphorylates	entity	0.60
BDNF	associated_with	entity	0.60
BDNF	activates	gene	0.60
CSF1R	inhibits	gene	0.60
MECP2	inhibits	gene	0.60
NEURON	expressed_in	gene	0.60
CREB	activates	gene	0.60
ERK	activates	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
DNA	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
RNA	inhibits	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
CREB	associated_with	gene	0.60
ERK	associated_with	gene	0.60
microglia	associated_with	cell_type	0.50
microglia	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found