protein

P2X7 RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2X7 RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

44Outgoing

13Incoming

0Experiments

Summary

Page for P2X7 Receptor Protein

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🔬 Protein Info

Gene Symbol	P2X7
Full Name	P2X Purinoceptor 7
Chromosome	12q24.31.
Protein Type	Channel
Function	is an ATP-gated ion channel encoded by the P2RX7 gene located on chromosome 12q24.
Molecular Weight	66 kDa
Amino Acids	595 aa
Exons	17
Pathways	Microrna, apoptosis, inflammation
GeneCards	P2X7
Human Protein Atlas	P2X7
Associated Diseases	Alzheimer'S Disease, Neurodegenerative Diseases, Pain, disease
Interactions	P2X7, NLRP3, IL-6, PHAGOCYTOSIS, P2RX7, adnp
KG Connections	56 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    P2X7_RECEPTOR["<b>P2X7 RECEPTOR</b>"]
    P2X7["P2X7"]
    P2X7_RECEPTOR -->|"activates"| P2X7
    apoptosis["apoptosis"]
    P2X7_RECEPTOR -->|"activates"| apoptosis
    Astrocyte["Astrocyte"]
    P2X7_RECEPTOR -->|"activates"| Astrocyte
    MICROGLIAL_ACTIVATION["MICROGLIAL ACTIVATION"]
    P2X7_RECEPTOR -->|"activates"| MICROGLIAL_ACTIVATION
    P2X7["P2X7"]
    P2X7_RECEPTOR -->|"associated with"| P2X7
    NLRP3["NLRP3"]
    P2X7_RECEPTOR -->|"associated with"| NLRP3
    INFLAMMASOME["INFLAMMASOME"]
    P2X7_RECEPTOR -->|"associated with"| INFLAMMASOME
    Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    P2X7_RECEPTOR -->|"associated with"| Nlrp3_Inflammasome
    P2X7["P2X7"]
    P2X7_RECEPTOR -->|"interacts with"| P2X7
    P2X7["P2X7"]
    P2X7_RECEPTOR -->|"regulates"| P2X7
    P2X7["P2X7"]
    P2X7_RECEPTOR -->|"inhibits"| P2X7
    NLRP3["NLRP3"]
    P2X7_RECEPTOR -->|"inhibits"| NLRP3
    INFLAMMASOME["INFLAMMASOME"]
    P2X7_RECEPTOR -->|"inhibits"| INFLAMMASOME
    Cardiac["Cardiac"]
    P2X7_RECEPTOR -->|"inhibits"| Cardiac
    Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    P2X7_RECEPTOR -->|"inhibits"| Nlrp3_Inflammasome
    CELL_PROLIFERATION["CELL PROLIFERATION"]
    P2X7_RECEPTOR -->|"activates"| CELL_PROLIFERATION
    Microrna["Microrna"]
    P2X7_RECEPTOR -->|"activates"| Microrna
    NEURONS["NEURONS"]
    P2X7_RECEPTOR -->|"associated with"| NEURONS
    Astrocytes["Astrocytes"]
    P2X7_RECEPTOR -->|"inhibits"| Astrocytes
    Astrocyte["Astrocyte"]
    P2X7_RECEPTOR -->|"inhibits"| Astrocyte
    Neuron["Neuron"]
    P2X7_RECEPTOR -->|"inhibits"| Neuron
    APP_PS1["APP/PS1"]
    P2X7_RECEPTOR -->|"inhibits"| APP_PS1
    NEURONS["NEURONS"]
    P2X7_RECEPTOR -->|"inhibits"| NEURONS
    MOTOR_NEURONS["MOTOR NEURONS"]
    P2X7_RECEPTOR -->|"activates"| MOTOR_NEURONS
    NEURONS["NEURONS"]
    P2X7_RECEPTOR -->|"activates"| NEURONS
    ALZHEIMER["ALZHEIMER"]
    P2X7_RECEPTOR -->|"associated with"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    P2X7_RECEPTOR -->|"associated with"| Alzheimer_S_Disease
    disease["disease"]
    P2X7_RECEPTOR -->|"associated with"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    P2X7_RECEPTOR -->|"associated with"| ALZHEIMER_S
    inflammation["inflammation"]
    P2X7_RECEPTOR -->|"associated with"| inflammation

Outgoing (44)

Target	Relation	Type	Str
SOD1	mediates_release_of	protein	0.80
P2X7	activates	protein	0.50
apoptosis	activates	process	0.50
Astrocyte	activates	cell_type	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
P2X7	associated_with	protein	0.50
NLRP3	associated_with	protein	0.50
Nlrp3 Inflammasome	associated_with	pathway	0.50
P2X7	interacts_with	protein	0.50
P2X7	regulates	protein	0.50
P2X7	inhibits	protein	0.50
NLRP3	inhibits	protein	0.50
Cardiac	inhibits	disease	0.50
Nlrp3 Inflammasome	inhibits	pathway	0.50
CELL PROLIFERATION	activates	concept	0.50
Microrna	activates	pathway	0.50
NEURONS	associated_with	concept	0.50
Astrocytes	inhibits	cell_type	0.50
Astrocyte	inhibits	cell_type	0.50
Neuron	inhibits	cell_type	0.50
APP/PS1	inhibits	concept	0.50
NEURONS	inhibits	concept	0.50
MOTOR NEURONS	activates	concept	0.50
NEURONS	activates	concept	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
inflammation	associated_with	pathway	0.50
Pain	associated_with	disease	0.50
Pain	regulates	disease	0.50
Pain	activates	disease	0.50
P2X7	expressed_in	protein	0.50
CYTOKINES	activates	concept	0.50
inflammation	regulates	pathway	0.50
Pain	inhibits	disease	0.50
Neurodegenerative Diseases	associated_with	disease	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
NEURODEGENERATIVE DISEASE	regulates	concept	0.50
MACROPHAGES	expressed_in	concept	0.50

Incoming (13)

Source	Relation	Type	Str
microglia	activates	cell_type	0.50
IL-6	activates	protein	0.50
DEPRESSION	associated_with	disease	0.50
microglia	associated_with	cell_type	0.50
PHAGOCYTOSIS	activates	gene	0.50
P2RX7	activates	gene	0.50
Neuroinflammation	activates	process	0.50
adnp	inhibits	gene	0.50
Sod1	activates	gene	0.50
Neurodegeneration	activates	disease	0.50
P2RX7	associated_with	gene	0.50
microglia	regulates	cell_type	0.50
microglia	expressed_in	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

P2X7 RECEPTOR

Understanding Entity Pages

Summary

Wiki Pages (20)

Therapeutics

neuroinflammation

ALS Failed Approaches Analysis

Neuroinflammation-Mitochondria Crosstalk Pathway

Ion Channel Dysfunction in Huntington's Disease

Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration

Calcium Signaling Dysregulation in Parkinson's Disease

Necroptotic Neurons

AD Biomarker-to-Mechanism Mapping

PET Imaging in Neurodegeneration

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

Neuroinflammation in Alzheimer's Disease

Microglia Activation Mechanism

Neuroinflammation in Alzheimer's Disease

Pain in Corticobasal Syndrome

nlrp3-inflammasome-activated-microglia

Section 99: Purinergic Signaling and P2X/P2Y Receptors in CBS/PSP

ASC (PYCARD)

Microglia