Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P2X7 RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | P2X7 |
| Full Name | P2X Purinoceptor 7 |
| Chromosome | 12q24.31. |
| Protein Type | Channel |
| Function | is an ATP-gated ion channel encoded by the P2RX7 gene located on chromosome 12q24. |
| Molecular Weight | 66 kDa |
| Amino Acids | 595 aa |
| Exons | 17 |
| Pathways | Microrna, apoptosis, inflammation |
| GeneCards | P2X7 |
| Human Protein Atlas | P2X7 |
| Associated Diseases | Alzheimer'S Disease, Neurodegenerative Diseases, Pain, disease |
| Interactions | P2X7, NLRP3, IL-6, PHAGOCYTOSIS, P2RX7, adnp |
| KG Connections | 56 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
P2X7_RECEPTOR["<b>P2X7 RECEPTOR</b>"]
P2X7["P2X7"]
P2X7_RECEPTOR -->|"activates"| P2X7
apoptosis["apoptosis"]
P2X7_RECEPTOR -->|"activates"| apoptosis
Astrocyte["Astrocyte"]
P2X7_RECEPTOR -->|"activates"| Astrocyte
MICROGLIAL_ACTIVATION["MICROGLIAL ACTIVATION"]
P2X7_RECEPTOR -->|"activates"| MICROGLIAL_ACTIVATION
P2X7["P2X7"]
P2X7_RECEPTOR -->|"associated with"| P2X7
NLRP3["NLRP3"]
P2X7_RECEPTOR -->|"associated with"| NLRP3
INFLAMMASOME["INFLAMMASOME"]
P2X7_RECEPTOR -->|"associated with"| INFLAMMASOME
Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
P2X7_RECEPTOR -->|"associated with"| Nlrp3_Inflammasome
P2X7["P2X7"]
P2X7_RECEPTOR -->|"interacts with"| P2X7
P2X7["P2X7"]
P2X7_RECEPTOR -->|"regulates"| P2X7
P2X7["P2X7"]
P2X7_RECEPTOR -->|"inhibits"| P2X7
NLRP3["NLRP3"]
P2X7_RECEPTOR -->|"inhibits"| NLRP3
INFLAMMASOME["INFLAMMASOME"]
P2X7_RECEPTOR -->|"inhibits"| INFLAMMASOME
Cardiac["Cardiac"]
P2X7_RECEPTOR -->|"inhibits"| Cardiac
Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
P2X7_RECEPTOR -->|"inhibits"| Nlrp3_Inflammasome
CELL_PROLIFERATION["CELL PROLIFERATION"]
P2X7_RECEPTOR -->|"activates"| CELL_PROLIFERATION
Microrna["Microrna"]
P2X7_RECEPTOR -->|"activates"| Microrna
NEURONS["NEURONS"]
P2X7_RECEPTOR -->|"associated with"| NEURONS
Astrocytes["Astrocytes"]
P2X7_RECEPTOR -->|"inhibits"| Astrocytes
Astrocyte["Astrocyte"]
P2X7_RECEPTOR -->|"inhibits"| Astrocyte
Neuron["Neuron"]
P2X7_RECEPTOR -->|"inhibits"| Neuron
APP_PS1["APP/PS1"]
P2X7_RECEPTOR -->|"inhibits"| APP_PS1
NEURONS["NEURONS"]
P2X7_RECEPTOR -->|"inhibits"| NEURONS
MOTOR_NEURONS["MOTOR NEURONS"]
P2X7_RECEPTOR -->|"activates"| MOTOR_NEURONS
NEURONS["NEURONS"]
P2X7_RECEPTOR -->|"activates"| NEURONS
ALZHEIMER["ALZHEIMER"]
P2X7_RECEPTOR -->|"associated with"| ALZHEIMER
Alzheimer_S_Disease["Alzheimer'S Disease"]
P2X7_RECEPTOR -->|"associated with"| Alzheimer_S_Disease
disease["disease"]
P2X7_RECEPTOR -->|"associated with"| disease
ALZHEIMER_S["ALZHEIMER'S"]
P2X7_RECEPTOR -->|"associated with"| ALZHEIMER_S
inflammation["inflammation"]
P2X7_RECEPTOR -->|"associated with"| inflammation| Target | Relation | Type | Str |
|---|---|---|---|
| P2X7 | activates | protein | 0.50 |
| apoptosis | activates | process | 0.50 |
| Astrocyte | activates | cell_type | 0.50 |
| MICROGLIAL ACTIVATION | activates | concept | 0.50 |
| P2X7 | associated_with | protein | 0.50 |
| NLRP3 | associated_with | protein | 0.50 |
| Nlrp3 Inflammasome | associated_with | pathway | 0.50 |
| P2X7 | interacts_with | protein | 0.50 |
| P2X7 | regulates | protein | 0.50 |
| P2X7 | inhibits | protein | 0.50 |
| NLRP3 | inhibits | protein | 0.50 |
| Cardiac | inhibits | disease | 0.50 |
| Nlrp3 Inflammasome | inhibits | pathway | 0.50 |
| CELL PROLIFERATION | activates | concept | 0.50 |
| Microrna | activates | pathway | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| Astrocytes | inhibits | cell_type | 0.50 |
| Astrocyte | inhibits | cell_type | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| APP/PS1 | inhibits | concept | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| MOTOR NEURONS | activates | concept | 0.50 |
| NEURONS | activates | concept | 0.50 |
| ALZHEIMER | associated_with | gene | 0.50 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| inflammation | associated_with | pathway | 0.50 |
| Pain | associated_with | disease | 0.50 |
| Pain | regulates | disease | 0.50 |
| Pain | activates | disease | 0.50 |
| P2X7 | expressed_in | protein | 0.50 |
| CYTOKINES | activates | concept | 0.50 |
| inflammation | regulates | pathway | 0.50 |
| Pain | inhibits | disease | 0.50 |
| Neurodegenerative Diseases | associated_with | disease | 0.50 |
| NEURODEGENERATIVE DISEASE | associated_with | concept | 0.50 |
| ALZHEIMER | regulates | gene | 0.50 |
| Alzheimer'S Disease | regulates | disease | 0.50 |
| disease | regulates | disease | 0.50 |
| ALZHEIMER'S | regulates | concept | 0.50 |
| NEURODEGENERATIVE DISEASE | regulates | concept | 0.50 |
| MACROPHAGES | expressed_in | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| microglia | activates | cell_type | 0.50 |
| IL-6 | activates | protein | 0.50 |
| DEPRESSION | associated_with | disease | 0.50 |
| microglia | associated_with | cell_type | 0.50 |
| PHAGOCYTOSIS | activates | gene | 0.50 |
| P2RX7 | activates | gene | 0.50 |
| Neuroinflammation | activates | process | 0.50 |
| adnp | inhibits | gene | 0.50 |
| Sod1 | activates | gene | 0.50 |
| Neurodegeneration | activates | disease | 0.50 |
| P2RX7 | associated_with | gene | 0.50 |
| microglia | regulates | cell_type | 0.50 |
| microglia | expressed_in | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||