gene

TRAF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRAF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

160Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

TNF Receptor Associated Factor 2 - E3 ubiquitin ligase involved in NF-κB signaling, neuroinflammation, and neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	TRAF2
Full Name	TNF Receptor Associated Factor 2
Aliases	TRAP, TNF-R2-associated factor, MORT1-associated protein
Chromosome	9q34.3
Protein Type	Ligase
Function	encodes a critical E3 ubiquitin ligase that serves as a central adaptor protein in TNF receptor signaling pathways.
Molecular Weight	56 kDa
Amino Acids	522 aa
Pathways	NF-κB signaling, NF-κB, MAPK
UniProt ID	Q9UAV6
NCBI Gene ID	7186
Ensembl ID	ENSG00000126933
OMIM	601985
GeneCards	TRAF2
Human Protein Atlas	TRAF2
Associated Diseases	Tumor
Interactions	TNF, STING, CGAS, TRAF6, IRF1, TGFBR1
KG Connections	160 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRAF2 — AlphaFold Q9UAV6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRAF2["TRAF2"]
    TRAF2 -->|"interacts"| Ms["Ms"]
    TRAF2 -->|"activates"| Inflammation["Inflammation"]
    TRAF2 -->|"activates"| Cardiac["Cardiac"]
    TRAF2 -->|"activates"| Tumor["Tumor"]
    TRAF2 -->|"activates"| Obesity["Obesity"]
    TRAF2 -->|"expressed in"| Als["Als"]
    TRAF2 -->|"expressed in"| Cancer["Cancer"]
    TRAF2 -->|"interacts"| Aging["Aging"]
    CD40["CD40"] -->|"interacts"| TRAF2
    TNF["TNF"] -->|"activates"| TRAF2
    MITOPHAGY["MITOPHAGY"] -->|"activates"| TRAF2
    UBIQUITIN["UBIQUITIN"] -->|"activates"| TRAF2
    INFLAMMATION["INFLAMMATION"] -->|"activates"| TRAF2
    ULK1["ULK1"] -->|"activates"| TRAF2
    MIRNAS["MIRNAS"] -->|"expressed in"| TRAF2
    CAV1["CAV1"] -->|"regulates"| TRAF2
    CD8["CD8"] -->|"activates"| TRAF2
    MAVS["MAVS"] -->|"interacts"| TRAF2

Outgoing (91)

Target	Relation	Type	Str
NF-κB Pathway	activates	pathway	0.90
Ms	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
Cardiac	activates	disease	0.65
Tumor	activates	disease	0.65
Obesity	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Lymphoma	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Infection	activates	disease	0.65
Schizophrenia	interacts_with	disease	0.65
TNF	activates	gene	0.60
DNM1L	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
STING	activates	gene	0.60
CGAS	activates	gene	0.60
SMAD3	regulates	gene	0.60
CREBBP	regulates	gene	0.60
RIPK1	associated_with	gene	0.60
TRAF6	interacts_with	gene	0.60
IRF1	interacts_with	gene	0.60
TGFBR1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
RAF1	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
ACVR1	interacts_with	gene	0.60
PINK1	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
IKBKE	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
MAVS	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
SESN2	associated_with	gene	0.60
FADD	associated_with	gene	0.60
TNF	associated_with	gene	0.60
DISC1	interacts_with	gene	0.60
Dendritic Spine	interacts_with	pathway	0.60
schizophrenia	interacts_with	disease	0.60
ULK1	activates	gene	0.60
Immune Response	activates	pathway	0.60
Autophagy	associated_with	pathway	0.60
Mitophagy	activates	pathway	0.60

Incoming (69)

Source	Relation	Type	Str
IRE1α	interacts_with	receptor	0.90
TIFA	interacts_with	protein	0.85
TNF	activates	gene	0.60
BCL2	associated_with	gene	0.60
FUNDC1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TNF	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MFF	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SESN2	associated_with	gene	0.60
STX17	associated_with	gene	0.60
MAVS	associated_with	gene	0.60
IKBKE	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
RIPK2	associated_with	gene	0.60
NR4A1	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
TUFM	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
ULK1	activates	gene	0.60
CAV1	regulates	gene	0.60
CD8	activates	gene	0.60
MAVS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
PIK3CA	interacts_with	gene	0.60
RANKINGS	interacts_with	gene	0.60
RAC1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
CBL	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
RHOA	interacts_with	gene	0.60
CGAS	activates	gene	0.60
GAIN	activates	gene	0.60
STING	activates	gene	0.60
NLRP3	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60
DISC1	interacts_with	gene	0.60
IRF3	inhibits	gene	0.60
SIRT5	inhibits	gene	0.60
TBK1	inhibits	gene	0.60
AUTOPHAGY	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TRAF2

Understanding Entity Pages

Summary

Wiki Pages (21)

TRAF2 Gene

rankings

er-stress-neurodegeneration

Necroptotic Neurons

Unfolded Protein Response (UPR)

IL32

Regulated Necrosis Hypothesis in Parkinson's Disease

NF-κB Signaling in Neurodegeneration

TNF Signaling Pathway in Neurodegeneration

p75NTR Protein

LTBR Gene

CASP12 (Caspase-12)

ER Stress Neurons

Necroptosis in Alzheimer's Disease

CBS ER Stress and Unfolded Protein Response Mechanisms

IL25 (Interleukin 25)

TUFM Gene

TNFSF12 Gene (TWEAK)

TNF Gene

ikkgamma