TEAD1

Understanding Entity Pages

This page aggregates everything SciDEX knows about TEAD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TEAD1 (TEA Domain Transcription Factor 1) is a transcription factor serving as the main effector of the Hippo signaling pathway. It regulates cell proliferation, differentiation, and survival. Implicated in Alzheimer's disease, cancer, and various developmental disorders.

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graph TD
    TEAD1["<b>TEAD1</b>"]
    Tumor{"Tumor"}
    TEAD1 -->|"therapeutic target"| Tumor
    Ms{"Ms"}
    TEAD1 -->|"therapeutic target"| Ms
    Glioblastoma{"Glioblastoma"}
    TEAD1 -->|"therapeutic target"| Glioblastoma
    EGFR["EGFR"]
    TEAD1 -->|"regulates"| EGFR
    FGFR3["FGFR3"]
    TEAD1 -->|"therapeutic target"| FGFR3
    GENES["GENES"]
    TEAD1 -->|"therapeutic target"| GENES
    NF1["NF1"]
    TEAD1 -->|"therapeutic target"| NF1
    IDH1["IDH1"]
    TEAD1 -->|"therapeutic target"| IDH1
    neurodegeneration["neurodegeneration"]
    TEAD1 -->|"implicated in"| neurodegeneration
    CDK4["CDK4"]
    CDK4 -->|"therapeutic target"| TEAD1
    GENES -->|"therapeutic target"| TEAD1
    EGFR -->|"regulates"| TEAD1
    IDH1 -->|"therapeutic target"| TEAD1
    NF1 -->|"therapeutic target"| TEAD1
    GLIOBLASTOMA["GLIOBLASTOMA"]
    GLIOBLASTOMA -->|"therapeutic target"| TEAD1
    FGFR3 -->|"therapeutic target"| TEAD1
    AND["AND"]
    AND -->|"regulates"| TEAD1
    style TEAD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0