Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TERC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TERC is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, contributes to. Associated with ALS, Aging, Als. Connected to 36 entities in the SciDEX knowledge graph.
| Gene Symbol | TERC |
| Full Name | Telomerase RNA Component |
| Chromosome | 3q26.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Amino Acids | ~451 nucleotides |
| Pathways | Telomere Dysfunction |
| NCBI Gene ID | 7012 |
| Ensembl ID | ENSG00000264364 |
| OMIM | 602322 |
| GeneCards | TERC |
| Human Protein Atlas | TERC |
| RNA Type | Long non-coding RNA (lncRNA) |
| Length | ~451 nucleotides |
| Associated Diseases | ALS, Inflammation, Ms, Senescence |
| Interactions | MICRORNAS, IL-6, IL-8 |
| KG Connections | 62 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
TERC["<b>TERC</b>"]
Senescence{"Senescence"}
TERC -->|"regulates"| Senescence
Als{"Als"}
TERC -->|"associated with"| Als
Ms{"Ms"}
TERC -->|"regulates"| Ms
Inflammation{"Inflammation"}
TERC -->|"regulates"| Inflammation
TERC -->|"associated with"| Inflammation
TERC -->|"associated with"| Senescence
Aging{"Aging"}
TERC -->|"contributes to"| Aging
TERC -->|"associated with"| Ms
Cancer{"Cancer"}
TERC -->|"contributes to"| Cancer
TERC -->|"expressed in"| Als
TERC -->|"expressed in"| Ms
Schizophrenia{"Schizophrenia"}
TERC -->|"expressed in"| Schizophrenia
TERT["TERT"]
TERT -->|"associated with"| TERC
AGING["AGING"]
AGING -->|"contributes to"| TERC
CANCER["CANCER"]
CANCER -->|"contributes to"| TERC
TERT -->|"expressed in"| TERC
AGING -->|"regulates"| TERC
CANCER -->|"regulates"| TERC
P21["P21"]
P21 -->|"regulates"| TERC
style TERC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Telomere Dysfunction | causes | mechanism | 0.95 |
| Telomere Dysfunction | regulates | mechanism | 0.85 |
| Telomere Maintenance | involved_in | process | 0.85 |
| Telomere Dysfunction | involved_in | process | 0.80 |
| Senescence | regulates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Senescence | associated_with | disease | 0.65 |
| Aging | contributes_to | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| TERT | associated_with | gene | 0.60 |
| TERT | contributes_to | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| MICRORNAS | interacts_with | gene | 0.60 |
| Epigenetic | contributes_to | pathway | 0.60 |
| Immune Response | contributes_to | pathway | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| CYTOKINES | regulates | gene | 0.60 |
| P16 | regulates | gene | 0.60 |
| IL-6 | regulates | gene | 0.60 |
| P21 | regulates | gene | 0.60 |
| Endothelial | regulates | cell_type | 0.60 |
| Monocyte | regulates | cell_type | 0.60 |
| RNA | associated_with | gene | 0.60 |
| Cytokine | regulates | protein | 0.60 |
| Tau | regulates | protein | 0.60 |
| Ras | associated_with | protein | 0.60 |
| Endothelial Cell | expressed_in | cell_type | 0.55 |
| CYTOKINES | activates | concept | 0.50 |
| Telomere | activates | pathway | 0.50 |
| MONOCYTE | activates | concept | 0.50 |
| CYTOKINES | associated_with | concept | 0.50 |
| Telomere | associated_with | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TERT | associated_with | gene | 0.60 |
| TERT | expressed_in | gene | 0.60 |
| TERT | encodes | gene | 0.60 |
| AGING | contributes_to | gene | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| P21 | regulates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| CYTOKINES | regulates | gene | 0.60 |
| IL-6 | regulates | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| P16 | regulates | gene | 0.60 |
| RNA | encodes | gene | 0.60 |
| IL-6 | activates | protein | 0.50 |
| IL-8 | activates | protein | 0.50 |
| IL-8 | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||