enzyme

USP5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

15Outgoing

21Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	USP5
Pathways	Autophagy, NF-kB signaling, autophagy pathway, oxidative stress response, ubiquitin-proteasome
GeneCards	USP5
Human Protein Atlas	USP5
Associated Diseases	Autophagy, NLRP3, NLRP3 Inflammasome Activation
Interactions	VEGF, AIM2, ASC, ATG5, CASP1, IL1B
KG Connections	36 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

USP13 Inhibitor for Mitophagy and Synaptic Proteostasis

idea · 1974 words

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UBC Protein

protein · 1620 words

→

Pathway Diagram

graph TD
    USP5["USP5"] -.->|"inhibits"| NLRP3["NLRP3"]
    style NLRP3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    USP5["USP5"] -->|"associated"| NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    style NLRP3_Inflammasome_Activation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    USP5["USP5"] -->|"activates"| Autophagy["Autophagy"]
    style Autophagy fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    USP5["USP5"] -.->|"inhibits"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style NLRP3_INFLAMMASOME fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    USP5["USP5"] -->|"substrate of"| Ubiquitin["Ubiquitin"]
    style Ubiquitin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style USP5 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (15)

Target	Relation	Type	Str
Autophagy	activates	process	0.90
NLRP3	downregulates	entity	0.90
NLRP3 inflammasome	attenuates	protein_complex	0.90
autophagy	promotes	process	0.90
NLRP3	promotes_autophagic_degradation_of	protein	0.80
NLRP3	promotes_autophagic_degradation	protein	0.80
NF-kB signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
VEGF	activates	gene	0.60
cancer	activates	disease	0.60
Notch signaling	participates_in	pathway	0.60
USP9X	implicated_in	gene	0.60

Incoming (21)

Source	Relation	Type	Str
AIM2	interacts_with	gene	0.60
ASC	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
CASP1	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
LAMP1	interacts_with	gene	0.60
MARCH7	interacts_with	gene	0.60
NFKB	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
NLRC4	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
PYCARD	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NOTCH1	activates	gene	0.60
RBPJ	activates	gene	0.60
CXCL1	activates	gene	0.60
STAT3	activates	gene	0.60
NOTCH1	causes	gene	0.60
STAT3	causes	gene	0.60
RNA	activates	gene	0.60
USP14	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found