protein

MARCH7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MARCH7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

Summary

MARCH7 Protein - MARCH7 is an E3 ubiquitin ligase that catalyzes ub...

View on Wiki →

🔬 Protein Info

Gene Symbol	MARCH7
Full Name	Membrane Associated Ring-CH Type Finger 7
Aliases	MARCH7 Protein
Protein Type	Ligase
Function	is an E3 ubiquitin ligase belonging to the MARCH family of membrane-associated RING-CH proteins.
Primary Expression	immune cells and lymphoid tissues, where it regulates various aspects of immune function [@wang2015]
Molecular Weight	75.3 kDa
Pathways	Apoptosis, Immune Response, Inflammasome, Innate Immunity, Mapk
Ensembl ID	ENSG00000136240
GeneCards	MARCH7
Human Protein Atlas	MARCH7
RING-CH domain	Catalytic domain for E3 ubiquitin ligase activity
Transmembrane regions	Allows membrane association
N-terminal regulatory domain	Controls substrate recognition
C-terminal domain	Mediates protein-protein interactions
Associated Diseases	Ms, Tumor
Interactions	UBIQUITIN, ASC, TRAF3, NLRC4, PYCARD, TNF
KG Connections	88 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MARCH7["<b>MARCH7</b>"]
    Ms{"Ms"}
    MARCH7 -->|"associated with"| Ms
    Tumor{"Tumor"}
    MARCH7 -->|"associated with"| Tumor
    PYCARD["PYCARD"]
    MARCH7 -->|"associated with"| PYCARD
    LAMP1["LAMP1"]
    MARCH7 -->|"associated with"| LAMP1
    Inflammasome(["Inflammasome"])
    MARCH7 -->|"associated with"| Inflammasome
    Autophagy(["Autophagy"])
    MARCH7 -->|"associated with"| Autophagy
    NLRP3["NLRP3"]
    MARCH7 -->|"associated with"| NLRP3
    NLRC4["NLRC4"]
    MARCH7 -->|"associated with"| NLRC4
    CASP1["CASP1"]
    MARCH7 -->|"associated with"| CASP1
    IL1B["IL1B"]
    MARCH7 -->|"associated with"| IL1B
    AIM2["AIM2"]
    MARCH7 -->|"associated with"| AIM2
    NFKB["NFKB"]
    MARCH7 -->|"associated with"| NFKB
    IL1B -->|"associated with"| MARCH7
    CASP1 -->|"associated with"| MARCH7
    ATG5["ATG5"]
    ATG5 -->|"associated with"| MARCH7
    NLRC4 -->|"associated with"| MARCH7
    ASC["ASC"]
    ASC -->|"associated with"| MARCH7
    NLRP3 -->|"associated with"| MARCH7
    AIM2 -->|"associated with"| MARCH7
    TNF["TNF"]
    TNF -->|"associated with"| MARCH7
    LAMP1 -->|"associated with"| MARCH7
    PYCARD -->|"associated with"| MARCH7
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| MARCH7
    NFKB -->|"associated with"| MARCH7
    style MARCH7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
UBIQUITIN	associated_with	gene	0.70
INFLAMMATION	activates	gene	0.70
Inflammasome	activates	pathway	0.70
Ms	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	activates	disease	0.65
Lymphoma	activates	disease	0.65
PYCARD	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
ASC	associated_with	gene	0.60
TNF	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
ASC	activates	gene	0.60
TRAF3	activates	gene	0.60
NLRC4	interacts_with	gene	0.60
PYCARD	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
Inflammasome	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
NFKB	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Innate Immunity	activates	pathway	0.60
Immune Response	activates	pathway	0.60
Mapk	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
AND	associated_with	gene	0.60
NLR	associated_with	gene	0.60
IL-1	associated_with	gene	0.60
NLR	interacts_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
USP5	interacts_with	gene	0.60
Macrophage	expressed_in	cell_type	0.55
UBIQUITIN	interacts_with	protein	0.50
NLRP3	interacts_with	protein	0.50
NLRC4	co_expressed_with	gene	0.50

Incoming (32)

Source	Relation	Type	Str
NLRP3	associated_with	gene	0.70
IL1B	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
ASC	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
TNF	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
NLRP3	activates	gene	0.60
DRD1	activates	gene	0.60
CBL	activates	gene	0.60
TNF	activates	gene	0.60
NOD2	activates	gene	0.60
ASC	interacts_with	gene	0.60
NFKB	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
IL-1	associated_with	gene	0.60
AIM2	interacts_with	gene	0.50
IL1B	interacts_with	gene	0.50
PYCARD	interacts_with	gene	0.50
CASP1	interacts_with	gene	0.50
NLRC4	interacts_with	gene	0.50
ATG5	interacts_with	gene	0.50
LAMP1	interacts_with	protein	0.50
IL1B	co_expressed_with	gene	0.50
LAMP1	co_expressed_with	protein	0.50
Autophagy	interacts_with	process	0.50
PYCARD/ASC	interacts_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MARCH7

Understanding Entity Pages

Summary

Wiki Pages (6)

MARCH7 — Membrane Associated Ring-CH Type Finger 7

E3 Ubiquitin Ligase System in Neurodegeneration

MARCHF1

MARCH7 Protein