Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PYRAMIDAL NEURONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PYRAMIDAL NEURONS |
| Summary | Principal excitatory neurons in cerebral cortex and hippocampus with triangular cell bodies |
| Key Genes/Proteins | Β-AMYLOID, DRD2 |
| Related Diseases | ALZHEIMER'S DISEASE, GABA |
Knowledge base pages for this entity
graph TD
PYRAMIDAL_NEURONS["PYRAMIDAL NEURONS"]
PYRAMIDAL_NEURONS -->|"contributes to"| Motor_Recovery["Motor Recovery"]
CamKII_ChR2["CamKII-ChR2"] -->|"expressed in"| PYRAMIDAL_NEURONS
CAMKII["CAMKII"] -->|"expressed in"| PYRAMIDAL_NEURONS
HIPPOCAMPUS["HIPPOCAMPUS"] -->|"inhibits"| PYRAMIDAL_NEURONS
NEURON["NEURON"] -->|"inhibits"| PYRAMIDAL_NEURONS
CORTEX["CORTEX"] -->|"activates"| PYRAMIDAL_NEURONS
METFORMIN["METFORMIN"] -->|"inhibits"| PYRAMIDAL_NEURONS| Target | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | highly_vulnerable | disease | 0.80 |
| FRONTAL CORTEX | associated_with | brain_region | 0.50 |
| DENTATE GYRUS | associated_with | brain_region | 0.50 |
| VISUAL CORTEX | associated_with | brain_region | 0.50 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
| CA1 | associated_with | brain_region | 0.45 |
| MOTOR CORTEX | associated_with | brain_region | 0.45 |
| METFORMIN | associated_with | drug | 0.45 |
| CA3 | associated_with | brain_region | 0.45 |
| PREFRONTAL CORTEX | associated_with | brain_region | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Β-AMYLOID | accumulates_intraneuronally | protein | 0.80 |
| ALZHEIMER'S DISEASE | produces | disease | 0.70 |
| NEURONS | inhibits | cell_type | 0.65 |
| HIPPOCAMPUS | treats | brain_region | 0.65 |
| HIPPOCAMPUS | activates | brain_region | 0.65 |
| GABA | expressed_in | phenotype | 0.60 |
| DRD2 | expressed_in | gene | 0.55 |
| HIPPOCAMPUS | inhibits | brain_region | 0.50 |
| NEURON | inhibits | cell_type | 0.50 |
| GLIAL FIBRILLARY ACIDIC PROTEIN | associated_with | biomarker | 0.45 |
| NEURON | activates | cell_type | 0.35 |
| CORTEX | activates | brain_region | 0.35 |
| CORTEX | expressed_in | brain_region | 0.35 |
| METFORMIN | inhibits | drug | 0.35 |
| GFAP | inhibits | gene | 0.35 |
| HIPPOCAMPUS | degrades | brain_region | 0.35 |
| ASTROCYTES | degrades | cell_type | 0.35 |
| MICROGLIA | degrades | cell_type | 0.35 |
| CORTEX | degrades | brain_region | 0.35 |
| INTERNEURONS | causes | cell_type | 0.35 |
| INTERNEURONS | interacts_with | cell_type | 0.35 |
| PREFRONTAL CORTEX | regulates | brain_region | 0.35 |
| CORTEX | regulates | brain_region | 0.35 |
| MOTOR NEURONS | degrades | cell_type | 0.35 |
| CASP3 | degrades | gene | 0.35 |
| ASTROCYTES | inhibits | cell_type | 0.35 |
| CORTEX | inhibits | brain_region | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||