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Can systemic CD38 activation be achieved without triggering pro-inflammatory responses that accelerate neurodegeneration?

OPEN

CD38's pleiotropic effects on NAD+ homeostasis, calcium signaling, and immune responses create therapeutic challenges. The debate identified this as a critical safety concern but provided no resolution for selective activation strategies. Source: Debate session sess_sda-2026-04-01-gap-v2-89432b95 (Analysis: sda-2026-04-01-gap-v2-89432b95)

Priority: 0.70 Domain: neuropharmacology Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: Can systemic CD38 activation be achieved without triggering pro-inflammatory responses that accelerate neurodegeneration? is a 0.7 priority gap in neuropharmacology. It has 0 linked hypotheses with average composite score 0.000. Status: open.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

Can systemic CD38 activation be achieved without triggering pro-inflammatory responses that accelerate neurodegeneration? — INVOKE-2 (completed)

📈 Living Dashboards
0
Hypotheses
0.000
Top Score
0.000
Avg Score
0
Debates
0.00
Avg Quality
0%
Resolution
0
Mechanistic Families
Gap Resolution Progress0%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)

No hypotheses linked to this gap yet.

🌊 Knowledge Graph Connections

activates (2)

CD38→InflammationCD38→NOTCH

associated with (9)

CD38→Lysosomal Cholesterol EffluxCD38→mitochondrial transferCD38→NeurodegenerationCD38→Immune ResponseCD38→NAMPT
▸ Show 4 more

catalyzes (1)

CD38→Nad

causes (1)

APOE→CD38

contributes to (1)

CD38→glucose homeostasis

expressed in (5)

CD38→AstrocytesCD38→NeuronsCD38→Microglial CellsCD38→NEURONSASTROCYTE→CD38

expresses (1)

CD38→MICROGLIA

inhibits (4)

NAD+ depletion→CD38CD38 inhibitors→CD38CD38→programmed cell deathCD38→Aging

interacts with (1)

CD38→MIRO1

involved in (4)

CD38→mitochondrial_transferCD38→NeuroinflammationCD38→ADENOSINERGIC PATHWAYCD38→NAD metabolism

markers (1)

CD38→MACROPHAGE

mediates (4)

CD38→NAD+ depletionCD38→Mitochondrial TransferCD38→mitochondrial transferCD38→STING

participates in (1)

CD38→ubiquitin-proteasome

protects against (1)

ASTROCYTE→CD38

regulates (6)

CD38→NadCD38→purinergic signalingCD38→NAD+ metabolismCD38→ATP productionCD38→FOXP3
▸ Show 1 more

suppresses (1)

CD38→APOPTOSIS

targets (2)

h-cb833ed8→CD38SDA-2026-04-01-gap-013→CD38

upregulates (5)

GJ-PD→CD38aerobic exercise→CD38Aging→CD38Geum japonicum Thunb. var. chinense-Potentilla decorata H. Andres→CD38GJ-PD herbal pair→CD38
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