concept

ALPK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALPK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

36Outgoing

6Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ALPK1
Key Genes/Proteins	TIFA, NF-ΚB, HMGB1, TRAF2, TNF, IL-1
Related Diseases	Brain Injury, Inflammation
Related Pathways	Immune Response

Pathway Diagram

graph TD
    ALPK1["ALPK1"]
    ALPK1 -->|"interacts"| TIFA["TIFA"]
    ALPK1 -->|"activates"| NF__B["NF-KappaB"]
    ALPK1 -->|"activates"| Inflammation["Inflammation"]
    ALPK1 -->|"activates"| TRAF2["TRAF2"]
    ALPK1 -->|"activates"| TNF["TNF"]
    ALPK1 -->|"activates"| IL_1["IL-1"]
    ALPK1 -->|"activates"| AND["AND"]
    INFLAMMATION["INFLAMMATION"] -->|"activates"| ALPK1
    TRAF2 -->|"activates"| ALPK1
    IL_1 -->|"activates"| ALPK1
    TNF -->|"activates"| ALPK1

Outgoing (36)

Target	Relation	Type	Str
TIFA	interacts_with	protein	0.95
NF-ΚB	activates	protein	0.95
Pyroptosis	mediates	process	0.90
Ferroptosis	mediates	process	0.90
Brain Injury	contributes_to	disease	0.90
Microglia	expressed_in	cell_type	0.90
Inflammation	activates	disease	0.65
TRAF2	activates	gene	0.60
TNF	activates	gene	0.60
IL-1	activates	gene	0.60
AND	activates	gene	0.60
Immune Response	causes	pathway	0.60
T Cell	activates	cell_type	0.60
INFLAMMATION	activates	gene	0.60
T Cell	transports	cell_type	0.60
Actin	activates	protein	0.60
Raf	activates	protein	0.60
stem cells	expressed_in	cell_type	0.60
stroke	regulates	disease	0.60
HMGB1	interacts_with	gene	0.60
stroke	interacts_with	disease	0.60
ferroptosis	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
HMGB1	activates	gene	0.60
GSDMD	activates	gene	0.60
JAK2	activates	gene	0.60
NLRP3	activates	gene	0.60
STAT3	activates	gene	0.60
JAK-STAT signaling	participates_in	pathway	0.60
HMGB1	inhibits	gene	0.60
stroke	activates	disease	0.60
NF-kB signaling	participates_in	pathway	0.60
T Cell	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55
astrocytes	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55

Incoming (6)

Source	Relation	Type	Str
HMGB1	interacts_with	protein	0.95
HMGB1	upregulates	protein	0.90
INFLAMMATION	activates	gene	0.60
TRAF2	activates	gene	0.60
IL-1	activates	gene	0.60
TNF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found