gene 1,643 words KG: ARG1
Contents

ARG1 — Arginase 1

🧬 Gene Info
Gene SymbolARG1
Full NameArginase 1
AliasesArginase-1, Liver arginase
Chromosome6q23.2
FunctionUrea cycle enzyme, hydrolyzes arginine to ornithine
Primary Expressionthe brain, where it plays important roles in modulating nitric oxide (NO) production, polyamine synthesis, and immune cell function[^2]
Molecular Weight34.7 kDa
Amino Acids330
PathwaysUrea cycle, Arginine metabolism
UniProt IDP05089
NCBI Gene ID383
Ensembl IDENSG00000118520
OMIM608313
GeneCardsARG1
Human Protein AtlasARG1
Associated DiseasesAging, Alzheimer, Cancer, Dementia, Ms, Tumor
InteractionsABCA1, ABCG1, AHR, AKT, AMPK, AND
KG Connections223 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (33)

TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64
← Prevpg 2/2

Related Analyses (14)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (1)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95

See Also (12)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with

Knowledge Graph (12 edges)

PENK expressed_in ARG1
NCAM1 expressed_in ARG1
DNMT1 expressed_in ARG1
AKT1 expressed_in ARG1
COMT expressed_in ARG1
DLGAP2 expressed_in ARG1
STAT3 expressed_in ARG1
ARG1 expressed_in DRD2
ARG1 expressed_in DNMT3A
ARG1 activates MAP1LC3B

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