Contents

PYCARD Gene

🧬 Gene Info

Gene Symbol	PYCARD
Protein Family	PYD/CARD adaptor family
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	PYCARD functions as the central adaptor in inflammasome signaling.
Mechanism of Action	PYCARD acts as a critical adaptor protein in inflammasome activation, facilitating pro-inflammatory caspase-1 recruitment and subsequent IL-1β/IL-18 processing, which contributes to neuroinflammatory processes in neurodegenerative conditions like Alzheimer's and Parkinson's disease. Its protein-protein interaction domains mediate inflammatory signal transduction, potentially amplifying neuronal damage through excessive immune response activation.
Subcellular Localization	Cytoplasm (inflammasome specks)
Druggability	Low (0.35)
Clinical Stage	Phase II
Molecular Weight	22 kDa
Amino Acids	90 aa
Pathways	Apoptosis, Inflammasome, Inflammatory response, PANoptosis, Pyroptosis
UniProt ID	Q9ULZ3
GeneCards	PYCARD
Human Protein Atlas	PYCARD
Associated Diseases	Aging, ALS, Alzheimer, Alzheimer's disease, Atherosclerosis, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AGING, AIF1, AIM2, ALZHEIMER, Amyloid-β
SciDEX Target	View Target Profile (1 clinical trials)
KG Connections	735 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph