| Gene Symbol | BCL2 |
| Aliases | B-cell lymphoma 2 |
| Protein Family | BCL-2 family (anti-apoptotic subfamily) |
| Function | Direct BAX/BAK inhibition |
| Molecular Weight | 26 kDa |
| Pathways | Akt, Apoptosis, Autophagy, BMP signaling, Bh4 Domain |
| UniProt ID | P10415 |
| GeneCards | BCL2 |
| Human Protein Atlas | BCL2 |
| BH3 domain | Required for interaction with pro-apoptotic family members |
| Transmembrane domain | Anchors BCL2 to the outer mitochondrial membrane, ER, and nuclear envelope |
| BH1 domain | Forms part of the hydrophobic pocket that binds BH3 domains |
| BH2 domain | Contributes to the binding interface for pro-apoptotic proteins |
| N-terminal flexible region | Contains regulatory sequences |
| Phosphorylation | BCL2 is phosphorylated on multiple serine/threonine residues |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | Abt263, ABT263, ABT-737, Adcs, berberine, BERBERINE |
| Interactions | ABCD3, ABP, ACETYL-COA, ACHE, Actin, AD |
| KG Connections | 2852 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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