gene 1,032 words KG: HNRNPA1 2026-03-21
kind:genesection:genesstate:published
Contents

HNRNPA1 - Heterogeneous Nuclear Ribonucleoprotein A1

🧬 Gene Info
Gene SymbolHNRNPA1
Full NameHeterogeneous Nuclear Ribonucleoprotein A1
AliasesPage for HNRNPA1
Chromosome12q13.13
FunctionIn neurons and other cell types, hnRNP A1 plays critical roles in multiple aspects of RNA metabolism and cellular stress response:
Primary ExpressionUbiquitous, high in brain and muscle
Molecular Weight38 kDa
Amino Acids372 aa
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDP09651
NCBI Gene ID3178
Ensembl IDENSG00000166086
OMIM164017
GeneCardsHNRNPA1
Human Protein AtlasHNRNPA1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Anxiety, Cancer, Carcinoma, Dementia
Known Drugs/CompoundsPACLITAXEL
InteractionsALOX15, USP7, RANK, RANKL, CALCOCO2, NDP52
KG Connections452 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Axonal RNA Transport Reconstitution
Score: 0.45
VCP-Mediated Autophagy Enhancement
Score: 0.41
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
PARP1 Inhibition Therapy
Score: 0.58

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: expressed_in
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: stabilizes

Knowledge Graph (12 edges)

HNRNPA1 activates LC3
HNRNPA1 interacts_with OPTN
HNRNPA1 degrades UBIQUITIN
HNRNPA1 degrades USP7
HNRNPA1 activates USP7
HNRNPA1 associated_with USP7
HNRNPA1 causes HNRNPA2B1
HNRNPA1 causes SQSTM1
HNRNPA1 causes TIA1
HNRNPA1 causes VCP