| Gene Symbol | HSF1 |
| Aliases | Page for HSF1 Gene, Page for HSF1 Protein |
| Function | HSF1 functions as a DNA-binding transcription factor that activates heat shock gene expression in response to various cellular stresses including heat, oxidative stress, and proteotoxic stress. |
| Primary Expression | cancers and promotes tumor survival through enhanced proteostasis and metabolic adaptation |
| Molecular Weight | 53 kDa |
| Pathways | NF-κB |
| Ensembl ID | ENSG00000185122 |
| GeneCards | HSF1 |
| Human Protein Atlas | HSF1 |
| Associated Diseases | Cancer, Dementia, Huntington, Huntington's disease, Neurodegeneration, Parkinson's Disease |
| Known Drugs/Compounds | DH1, M102 |
| Interactions | AKT, MTOR, HDAC6, LRRK2, GAIN, CAT |
| KG Connections | 235 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |