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gene 2,230 words KG: MYOT
Contents

MYOT Gene

🧬 Gene Info
Gene SymbolMYOT
Chromosome19q13.33
Functionis a gene encoding a Z-disc protein critical for sarcomere organization and maintenance.
Molecular Weight57 kDa
Amino Acids493 aa
Exons13
Pathwaysubiquitin-proteasome
Ensembl IDENSG00000136244
GeneCardsMYOT
Human Protein AtlasMYOT
Associated Diseasesmyofibrillar myopathy
InteractionsAUTOPHAGY, BRCA1, DES, DNAJB6, FLNC, GENES
KG Connections149 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (93)

Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
Score: 0.63Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62Low Complexity Domain Cross-Linking Inhibition
Score: 0.62Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60VCP-Mediated Autophagy Enhancement
Score: 0.59CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
← Prevpg 4/5Next →

Related Analyses (27)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: co_discussedAMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussedAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activatesGenes
index · KG edge: activatesABCD3 Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

MYOT causes myofibrillar myopathy
MYOT causes Myofibrillar Myopathy
BRCA1 degrades MYOT
DES degrades MYOT
DNAJB6 degrades MYOT
FLNC degrades MYOT
MYOT degrades NBR1
MYOT degrades P62
MYOT degrades SQSTM1
BRCA1 activates MYOT

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