gene 1,125 words KG: RET 2026-03-23
kind:genesection:genesstate:published
Contents

RET Gene

🧬 Gene Info
Gene SymbolRET
Chromosome10q11.21
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight120 kDa
Amino Acids114 aa
Exons21
PathwaysPI3K, mTOR, mtor, MAPK
GeneCardsRET
Human Protein AtlasRET
IsoformExon Composition
RET9Excludes exon 11
RET10Includes exon 11
RET51Includes exons 11+12
PathwayKey Effectors
Associated DiseasesALS, Ataxia, Melanoma, Ms, Parkinson
InteractionsNRG1, EGFR, SRC, LMNA, KIF5B, OPTN
KG Connections131 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Hypocretin-Neurogenesis Coupling Therapy
Score: 0.45
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: associated_with
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: inhibits
PTEN Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

RET inhibits NRG1
RET activates EGFR
RET regulates GDNF
RET activates SRC
RET interacts_with LMNA
RET interacts_with KIF5B
RET interacts_with OPTN
RET interacts_with MYC
RET therapeutic_target OVERVIEW
RET expressed_in H3F3A