gene 1,081 words KG: RPS6 2026-03-25
kind:genesection:genesstate:published
Contents

RPS6 Gene

🧬 Gene Info
Gene SymbolRPS6
AliasesRibosomal Protein S6
Chromosome9p21.1
Functionencodes a protein of 249 amino acids.
Primary Expressionneurons and glial cells
Molecular Weight28.7 kDa
Amino Acids249 aa
PathwaysmTOR signaling, mTOR pathway, mTOR
Ensembl IDENSG00000143977
GeneCardsRPS6
Human Protein AtlasRPS6
Associated DiseasesAD, ADH, AMI, Cancer, Ischemia, Metabolic Syndrome
Known Drugs/Compoundsrapamycin
InteractionsRHEB, AKT1, RPS6KB1, PDPK1, TSC2, EIF4EBP1
KG Connections213 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
EIF4EBP1 — Eukaryotic Translation Initiation Factor 4E
gene · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates

Knowledge Graph (12 edges)

RPS6 regulates MAP1LC3B
RPS6 regulates MTOR
RPS6 regulates CTSD
RPS6 regulates LAMP1
RPS6 regulates MYC
RPS6 regulates SQSTM1
RPS6 regulates EIF4EBP1
RPS6 regulates RPS6KB1
RPS6 regulates PPARA
RPS6 regulates PPARGC1A