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mechanism 1,936 words KG: PHF6 2026-03-23
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

Thioflavin-T Fluorescence Assay for Protein Aggregation

⚙ Mechanism Info
NameThioflavin-T Fluorescence Assay for Protein Aggregation
SummaryPage for Thioflavin-T Fluorescence Assay for Protein Aggregation
Key Genes/ProteinsEP300, NOTCH1, PIK3R1, PIK3CA, IDH1, TP53
Related DiseasesAls, Leukemia
Related PathwaysNotch, Pi3K

Knowledge Graph

Related Hypotheses (18)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59Competitive APOE4 Domain Stabilization Peptides
Score: 0.56APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (30)

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Related Experiments (5)

IDH1 and IDH2 mutation sequencing in CNS and non-CNS tumors
exploratory · proposed · Score: 0.95Clinical outcome analysis based on IDH mutation status
clinical · proposed · Score: 0.85Spatial transcriptomic analysis of multistage ESCC developme
exploratory · proposed · Score: 0.85Functional analysis of EFNB1-EPHB4 interaction in EMT
exploratory · proposed · Score: 0.80Analysis of TP53-TP63/ΔNP63-EFNB1-EPHB4 axis in cancer progr
exploratory · proposed · Score: 0.75

Knowledge Graph (12 edges)

PHF6 associated_with EP300
PHF6 therapeutic_target NOTCH1
PHF6 associated_with PIK3R1
PHF6 therapeutic_target Als
PHF6 therapeutic_target Leukemia
PHF6 therapeutic_target Notch
PHF6 associated_with Pi3K
PIK3CA associated_with PHF6
IDH1 associated_with PHF6
TP53 associated_with PHF6
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