protein 2,396 words KG: ATG7
Contents

ATG7 Protein — Autophagy-Related Protein 7

🔬 Protein Info
Gene SymbolATG7
Full NameAutophagy Related 7
Chromosome3p22.1
Protein TypeProtein
Functionis an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight78 kDa
PathwaysAngiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt IDO95352
NCBI Gene ID9459
Ensembl IDENSG00000198271
OMIM607760
GeneCardsATG7
Human Protein AtlasATG7
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compoundscurcumin, CURCUMIN, nicotinamide, rapamycin, RAPAMYCIN
InteractionsACETYL-COA, ACHE, ACSL4, ACTB, Actin, AD
SciDEX HypothesesAstrocyte-specific autophagy deficiency induces NA
Autophagy Enhancement for Tau Clearance
Oligodendroglial Autophagy Enhancement
KG Connections1420 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (46)

HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
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Related Analyses (18)

Does TRPML1 enhancement cause therapeutic benefit or paradox
neurodegeneration · completed
Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: degrades

Knowledge Graph (12 edges)

ATG7 activates ENDOTHELIAL_IMPAIRMENT
paeoniflorin contributes_to ATG7
ACTB associated_with ATG7
LAMP1 activates ATG7
MTOR activates ATG7
LC3 activates ATG7
TUBB3 activates ATG7
ATG7 activates JUN
ATG7 activates SQSTM1
ATG7 activates MAP2

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