concept

GLIOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLIOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

154Connections

0Hypotheses

0Analyses

37Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GLIOSIS
Key Genes/Proteins	C9orf72 repeat expansion, AMYLOID, AQP4, ATP13A2, TAU, SOD1
Related Diseases	SYNAPTIC PLASTICITY, COGNITIVE DECLINE, STROKE, NEURODEGENERATION, NEUROINFLAMMATION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLIOSIS["GLIOSIS"]
    GLIOSIS -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    GLIOSIS -->|"activates"| NF_KB["NF-KB"]
    GLIOSIS -->|"activates"| NEURON["NEURON"]
    GLIOSIS -->|"activates"| MAPK["MAPK"]
    GLIOSIS -->|"activates"| JNK["JNK"]
    GLIOSIS -->|"activates"| P38["P38"]
    GLIOSIS -->|"activates"| GSH["GSH"]
    GLIOSIS -->|"activates"| SYNAPTIC_PLASTICITY["SYNAPTIC PLASTICITY"]
    FN1["FN1"] -->|"causes"| GLIOSIS
    fn1b["fn1b"] -->|"inhibits"| GLIOSIS
    JNK -->|"regulates"| GLIOSIS
    ASTROCYTES["ASTROCYTES"] -->|"activates"| GLIOSIS
    APOPTOSIS["APOPTOSIS"] -->|"activates"| GLIOSIS
    EPILEPSY["EPILEPSY"] -->|"regulates"| GLIOSIS
    ALS["ALS"] -->|"regulates"| GLIOSIS

Outgoing (37)

Target	Relation	Type	Str
SYNAPTIC PLASTICITY	inhibits	phenotype	0.65
COGNITIVE DECLINE	regulates	phenotype	0.65
STROKE	treats	disease	0.65
AQP4	inhibits	gene	0.65
NEURONS	produces	cell_type	0.65
ATP13A2	activates	gene	0.65
NEURODEGENERATION	treats	disease	0.65
HIPPOCAMPUS	expressed_in	brain_region	0.55
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
NEURODEGENERATION	activates	process	0.50
NF-KB	activates	gene	0.50
RETINA	associated_with	brain_region	0.45
N-ACETYLCYSTEINE	associated_with	drug	0.45
NAC	associated_with	drug	0.45
CORTEX	associated_with	brain_region	0.45
NEURODEGENERATION	associated_with	process	0.35
NEURON	activates	cell_type	0.35
MAPK	activates	gene	0.35
JNK	activates	gene	0.35
P38	activates	gene	0.35
GSH	activates	gene	0.35
SYNAPTIC PLASTICITY	activates	process	0.35
TAU	interacts_with	protein	0.35
NEURON	associated_with	cell_type	0.35
NEURODEGENERATION	regulates	process	0.35
TAU	phosphorylates	protein	0.35
TNF	activates	gene	0.35
TAU	activates	protein	0.35
NEUROTOXICITY	regulates	process	0.35
OLIGODENDROCYTES	associated_with	cell_type	0.35
SPINAL CORD	activates	brain_region	0.35
RETINA	activates	brain_region	0.35
N-ACETYLCYSTEINE	activates	drug	0.35
N-ACETYLCYSTEINE	inhibits	drug	0.35
N-ACETYLCYSTEINE	protects_against	drug	0.35
HIPPOCAMPUS	activates	brain_region	0.35

Incoming (117)

Source	Relation	Type	Str
C9orf72 repeat expansion	causes	gene	0.80
AMYLOID	regulates	protein	0.70
TAU	exacerbates	protein	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
SOD1	regulates	gene	0.65
LAG3	regulates	gene	0.65
SUBSTANTIA NIGRA	inhibits	brain_region	0.65
QUERCETIN	treats	drug	0.65
QUERCETIN	inhibits	drug	0.65
ASTROCYTES	causes	cell_type	0.65
CLU	causes	gene	0.65
MICROGLIA	regulates	cell_type	0.65
SUBSTANTIA NIGRA	interacts_with	brain_region	0.65
INFLAMMATION	activates	phenotype	0.65
INFLAMMATION	inhibits	phenotype	0.65
APOE	regulates	gene	0.65
NRF2	inhibits	gene	0.65
NRF2	regulates	gene	0.65
ASTROCYTES	activates	cell_type	0.65
APOPTOSIS	depleted_in	phenotype	0.55
P38	depleted_in	gene	0.55
GFAP	implicated_in	gene	0.55
aging	inhibits	phenotype	0.50
Astrocytes	inhibits	cell_type	0.50
Neurodegeneration	associated_with	disease	0.50
GADD45G	associated_with	gene	0.50
disease	associated_with	disease	0.50
Neurodegeneration	activates	disease	0.50
GADD45G	activates	gene	0.50
Astrocytes	activates	cell_type	0.50
DNA DAMAGE	activates	concept	0.50
GADD45G	expressed_in	gene	0.50
ALZHEIMER	expressed_in	gene	0.50
Alzheimer'S Disease	expressed_in	disease	0.50
Astrocytes	expressed_in	cell_type	0.50
SYNAPSE	expressed_in	concept	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
IRF3	activates	gene	0.50
MAP3K4	activates	gene	0.50
NF-κB	activates	concept	0.50
Neuron	activates	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Spinal Cord	activates	cell_type	0.50
Proteins	activates	protein	0.50
ISCHEMIC	activates	concept	0.50
Neuroprotection	activates	process	0.50
NADPH	activates	protein	0.50
apoptosis	activates	process	0.50
MAPK	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLIOSIS

Understanding Entity Pages

Wiki Pages (20)

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