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protein 1,200 words KG: KEAP1
Contents

KEAP1 - Kelch-like ECH-Associated Protein 1

🔬 Protein Info
Gene SymbolKEAP1
Full NameKelch-like ECH-Associated Protein 1
AliasesPage for KEAP1
Protein TypeAdaptor Protein
FunctionHigh-Affinity Binding: ETGE motif of NRF2 binds to one Kelch domain (hinge)
Molecular Weight70 kDa
Amino Acids624 aa
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Differentiation
UniProt IDQ14145
GeneCardsKEAP1
Human Protein AtlasKEAP1
Associated DiseasesAging, Als, Alzheimer, AUTOPHAGY, Cancer
Known Drugs/CompoundsDOXORUBICIN, Epalrestat, EPALRESTAT, EPS, Fumarate, gastrodin
InteractionsACHE, ACOD1, Actin, AD, AGING, AIFM1
KG Connections1189 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (26)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78CYP46A1 Overexpression Gene Therapy
Score: 0.77APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74Aquaporin-4 Polarization Rescue
Score: 0.73Senescence-Associated Myelin Lipid Remodeling
Score: 0.73Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
pg 1/2Next →

Related Analyses (14)

Epigenetic reprogramming in aging neurons
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (4)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: regulatesAlzheimer Indonesia
institution · KG edge: activatesAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

KEAP1 inhibits NFE2L2
NRF2 interacts_with KEAP1
NRF2 inhibits KEAP1
KEAP1 regulates NRF2
KEAP1 interacts_with CUL3
KEAP1 associated_with CCRCC
EPS interacts_with KEAP1
P62 interacts_with KEAP1
KEAP1 activates NRF2
KEAP1 activates ULK1

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