protein 1,200 words KG: KEAP1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

KEAP1 - Kelch-like ECH-Associated Protein 1

🔬 Protein Info
Gene SymbolKEAP1
Full NameKelch-like ECH-Associated Protein 1
AliasesPage for KEAP1
Protein TypeAdaptor Protein
FunctionHigh-Affinity Binding: ETGE motif of NRF2 binds to one Kelch domain (hinge)
Molecular Weight70 kDa
Amino Acids624 aa
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Differentiation
UniProt IDQ14145
GeneCardsKEAP1
Human Protein AtlasKEAP1
CysteineFunction
C151Conformational sensor
C273, C288Core functional
C226, C613Auxiliary sensors
Associated DiseasesALS, AUTOPHAGY, Aging, Alzheimer, CCRCC
Known Drugs/CompoundsDOXORUBICIN, rapamycin, EPS, gastrodin, Tocopherol, Succinic Anhydride
InteractionsCUL3, NRF2, ULK1, SQSTM1, NFE2L2, EGF
KG Connections1152 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (26)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59

Related Analyses (15)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (4)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: regulates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

KEAP1 degrades P62
KEAP1 associated_with NFE2L2
KEAP1 phosphorylates NFE2L2
KEAP1 phosphorylates SQSTM1
KEAP1 phosphorylates ULK1
KEAP1 protects_against NFE2L2
KEAP1 protects_against SQSTM1
KEAP1 regulates MTOR
KEAP1 regulates PI3K
KEAP1 mediates NRF2